LOCUS HPV6b 7902 bp ds-DNA circular VRL 11-MAR-1994 DEFINITION Human papillomavirus type 6b (HPV-6b), complete genome. ACCESSION X00203 KEYWORDS complete genome; overlapping genes. SOURCE Human papilloma virus type 6b DNA. ORGANISM Human papillomavirus type 6b Viridae; ds-DNA nonenveloped viruses; Papovaviridae; Papillomavirus. REFERENCE 1 (bases 1 to 7902) AUTHORS Schwarz,E., Duerst,M., Demankowski,C., Lattermann,O., Zech,R., Wolfsperger,E., Suhai,S. and Zur Hausen,H. TITLE DNA sequence and genome organization of genital human papillomavirus type 6b JOURNAL EMBO J. 2, 2341-2348 (1983) STANDARD full staff_review COMMENT HPV-11 and HPV-6 are responsible for the large majority of exophytic condylomas in the genital tract. Even though these lesions are frequently present in the genital tract, they are virtually absent in higher grade neoplasias and in cervical cancers. HPV-6 also infects other mucosal types; the respiratory tract, oral cavity and conjunctiva. It has been recovered from approximately 50% of respiratory tract lesions and 50% of all childhood conjunctival papillomas. Respiratory papillomatosis is a rare disease that can be life-threatening because of its recurrent nature and the possibility of obstruction of the airways and respiratory distress. The most frequent sites of infection are the vocal cords in the larynx, but papillomas may also be present in the trachea, lungs, nose and oral cavity. These respiratory papillomas progress to malignancy rarely, as they account for less than 0.1% of all respiratory cancers. The 7902 bp complete genome of HPV-6b has been cloned in pBR322 and in lambda and was originally recovered from a genital wart. The sense strand has been numbered by comparative analysis with BPV-1 and HPV-1a. Both the E6 and E7 ORFs contain conserved Cys-X-X-Cys cysteine doublet motifs. The E6 ORF contains four of these motifs separated by 29, 36 and 29 intervening amino acids, while the E7 ORF contains just two separated by 29 amino acids. The E6 ORF also contains a small intron. The E5a ORF codes for a protein of 91 amino acids. It has a stretch of 13 amino acids which is very rich in leucine. The L2 ORF contains an extremely conserved cluster of basic residues both at the N terminus and at the C terminus ends. The authors feel that the conserved region of this part of this peptide may interact with the conserved L1 structural peptide, where the variable region may be involved with host or tissue specific functions. Between the end of L1 and the beginning of E6 lies a small open reading frame E8. The first methionine is located in the middle of the ORF and it has no analog to other papillomaviruses sequenced at the time of publication. Because of these facts, this ORF is probably not functional. Thus, the region from the end of L1 to the beginning of E6 is probably the noncoding region containing the promoter and origin of replication. Within the first segment of this region lies a monotonous repetition of thymine-purine which is just slightly disturbed. Two repeats can be identified within the LCR; a 24 bp tandem repeat and a 9 bp direct repeat. A TATA box is located at nt 64 and a cap site is located directly in front of the E6 methionine codon. FEATURES Location/Qualifiers 5'UTR join(7292..7902,1..29) /note="putative" CDS join(7746..7902,1..5) /note="probably not functional" /note="E8 from bp 7611 to 5" /gene="E8" /note="putative" /codon_start=1 /translation="MHCSQLLKAFLACSSTFFCSYCLVYNNIKMSNLRSHTCDRFRLS TPYIFPSYS" TATA_signal 64..70 misc_feature 98..104 /note="cap site" /note="putative" CDS 102..554 /note="ORF E6 from bp 30 to 554" /product="transforming protein" /gene="E6" /note="putative" /codon_start=1 /translation="MESANASTSATTIDQLCKTFNLSMHTLQINCVFCKNALTTAEIY SYAYKHLKVLFRGGYPYAACACCLEFHGKINQYRHFDYAGYATTVEEETKQDILDVLI RCYLCHKPLCEVEKVKHILTKARFIKLNCTWKGRCLHCWTTCMEDMLP" misc_feature 141..142 /note="splice acceptor following E7" /note="putative" intron 450..503 /note="contained in the E6 ORF" /note="putative" CDS 530..826 /note="ORF E7 from 440 to 826" /product="transforming protein" /gene="E7" /note="putative" /codon_start=1 /translation="MHGRHVTLKDIVLDLQPPDPVGLHCYEQLVDSSEDEVDEVDGQD SQPLKQHFQIVTCCCGCDSNVRLVVQCTETDIREVQQLLLGTLNIVCPICAPKT" misc_feature 820..821 /note="splice acceptor following E1" /note="putative" CDS 832..2781 /note="ORF E1 from bp 715 to 2781" /product="replication protein" /gene="E1" /note="putative" /codon_start=1 /translation="MADDSGTENEGSGCTGWFMVEAIVQHPTGTQISDDEDEEVEDSG YDMVDFIDDSNITHNSLEAQALFNRQEADTHYATVQDLKRKYLGSPYVSPINTIAEAV ESEISPRLDAIKLTRQPKKVKRRLFQTRELTDSGYGYSEVEAGTGTQVEKHGVPENGG DGQEKDTGRDIEGEEHTEAEAPTNSVREHAGTAGILELLKCKDLRAALLGKFKECFGL SFIDLIRPFKSDKTTCLDWVVAGFGIHHSISEAFQKLIEPLSLYAHIQWLTNAWGMVL LVLLRFKVNKSRSTVARTLATLLNIPENQMLIEPPKIQSGVAALYWFRTGISNASTVI GEAPEWITRQTVIEHGLADSQFKLTEMVQWAYDNDICEESEIAFEYAQRGDFDSNARA FLNSNMQAKYVKDCATMCRHYKHAEMRKMSIKQWIKHRGSKIEGTGNWKPIVQFLRHQ NIEFIPFLTKFKLWLHGTPKKNCIAIVGPPDTGKSYFCMSLISFLGGTVISHVNSSSH FWLQPLVDAKVALLDDATQPCWIYMDTYMRNLLDGNPMSIDRKHKALTLIKCPPLLVT SNIDITKEDKYKYLHTRVTTFTFPNPFPFDRNGNAVYELSNTNWKCFFERLSSSLDIQ DSEDEEDGSNSQAFRCVPGTVVRTL" misc_feature 1279..1280 /note="splice donor in E1" /note="putative" misc_feature 2678..2679 /note="splice acceptor following E2" /note="putative" CDS 2723..3829 /note="ORF E2 from bp 2696 to 3829" /product="regulatory protein" /gene="E2" /note="putative" /codon_start=1 /translation="MEAIAKRLDACQEQLLELYEENSTDLHKHVLHWKCMRHESVLLY KAKQMGLSHIGMQVVPPLKVSEAKGHNAIEMQMHLESLLRTEYSMEPWTLQETSYEMW QTPPKRCFKKRGKTVEVKFDGCANNTMDYVVWTDVYVQDNDTWVKVHSMVDAKGIYYT CGQFKTYYVNFVKEAEKYGSTKHWEVCYGSTVICSPASVSSTTQEVSIPESTTYTPAQ TSTLVSSSTKEDAVQTPPRKRARGVQQSPCNALCVAHIGPVDSGNHNLITNNHDQHQR RNNSNSSATPIVQFQGESNCLKCFRYRLNDRHRHLFDLISSTWHWASSKAPHKHAIVT VTYDSEEQRQQFLDVVKIPPTISHKLGFMSLHLL" misc_feature 3242..3243 /note="splice acceptor following E4" /note="putative" CDS 3255..3584 /note="ORF E4 from bp 3240 to 3584" /gene="E4" /note="putative" /codon_start=1 /translation="MGAPNIGKYVMAAQLYVLLHLYLALHKKYPFLNLLHTPPHRPPP LCPQAPRKTQCKRRLGNEHEESNSPLATPCVWPTLDPWTVETTTSSLTITTSTKDGTT VTVQLRL" misc_feature 3596..3597 /note="splice donor behind E4" /note="putative" CDS 3887..4162 /note="ORF E5a from bp 3872 to 4162" /gene="E5a" /note="putative" /codon_start=1 /translation="MEVVPVQIAAGTTSTFILPVIIAFVVCFVSIILIVWISEFIVYT SVLVLTLLLYLLLWLLLTTPLQFFLLTLLVCYCPALYIHYYIVTTQQ" CDS 4159..4377 /note="ORF E5b from bp 4003 to 4377" /gene="E5b" /note="putative" /codon_start=1 /translation="MMLTCQFNDGDTWLGLWLLCAFIVGMLGLLLMHYRAVQGDKHTK CKKCNKHNCNDDYVTMHYTTDGDYIYMN" misc_feature 4405..4406 /note="splice acceptor following L2" /note="putative" CDS 4423..5802 /note="ORF L2 from bp 4378 to 5802" /product="minor capsid protein" /gene="L2" /note="putative" /codon_start=1 /translation="MAHSRARRRKRASATQLYQTCKLTGTCPPDVIPKVEHNTIADQI LKWGSLGVFFGGLGIGTGSGTGGRTGYVPLQTSAKPSITSGPMARPPVVVEPVAPSDP SIVSLIEESAIINAGAPEIVPPAHGGFTITSSETTTPAILDVSVTSHTTTSIFRNPVF TEPSVTQPQPPVEANGHILISAPTVTSHPIEEIPLDTFVVSSSDSGPTSSTPVPGTAP RPRVGLYSRALHQVQVTDPAFLSTPQRLITYDNPVYEGEDVSVQFSHDSIHNAPDEAF MDIIRLHRPAIASRRGLVRYSRIGQRGSMHTRSGKHIGARIHYFYDISPIAQAAEEIE MHPLVAAQDDTFDIYAESFEPGINPTQHPVTNISDTYLTSTPNTVTQPWGNTTVPLSL PNDLFLQSGPDITFPTAPMGTPFSPVTPALPTGPVFITGSGFYLHPAWYFARKRRKRI PLFFSDVAA" polyA_signal 4554..4560 /note="putative" misc_feature 5788..5789 /note="splice acceptor following L1" /note="putative" CDS 5789..7291 /note="ORF L1 from bp 5678 to 7291" /product="major capsid protein" /gene="L1" /note="putative" /codon_start=1 /translation="MWRPSDSTVYVPPPNPVSKVVATDAYVTRTNIFYHASSSRLLAV GHPYFSIKRANKTVVPKVSGYQYRVFKVVLPDPNKFALPDSSLFDPTTQRLVWACTGL EVGRGQPLGVGVSGHPFLNKYDDVENSGSGGNPGQDNRVNVGMDYKQTQLCMVGCAPP LGEHWGKGKQCTNTPVQAGDCPPLELITSVIQDGDMVDTGFGAMNFADLQTNKSDVPI DICGTTCKYPDYLQMAADPYGDRLFFFLRKEQMFARHFFNRAGEVGEPVPDTLIIKGS GNRTSVGSSIYVNTPSGSLVSSEAQLFNKPYWLQKAQGHNNGICWGNQLFVTVVDTTR STNMTLCASVTTSSTYTNSDYKEYMRHVEEYDLQFIFQLCSITLSAEVMAYIHTMNPS VLEDWNFGLSPPPNGTLEDTYRYVQSQAITCQKPTPEKEKPDPYKNLSFWEVNLKEKF SSELDQYPLGRKFLLQSGYRGRSSIRTGVKRPAVSKASAAPKRKRAKTKR" repeat_region 7292..7339 /rpt_unit=7292..7315,7316..7339 /standard_name="24 bp tandem repeat" /note="putative" misc_feature 7368..7369 /note="splice donor noncoding region" /note="putative" polyA_signal 7407..7412 /note="putative" repeat_region 7450..7474 /rpt_unit=7450..7458, 7466..7474 /standard_name="nonanucleotide direct repeat" /note="putative" source 1..7902 /organism="Human papillomavirus type 6" /sequenced_mol="DNA" BASE COUNT 2438 a 1530 c 1699 g 2235 t ORIGIN 1 gttaataaca atcttggttt aaaaaatagg agggaccgaa aacggttcaa ccgaaaacgg 61 ttgtatataa accagcccta aaatttagca aacgaggcat tatggaaagt gcaaatgcct 121 ccacgtctgc aacgaccata gaccagttgt gcaagacgtt taatctatct atgcatacgt 181 tgcaaattaa ttgtgtgttt tgcaagaatg cactgaccac agcagagatt tattcatatg 241 catataaaca cctaaaggtc ctgtttcgag gcggctatcc atatgcagcc tgcgcgtgct 301 gcctagaatt tcatggaaaa ataaaccaat atagacactt tgattatgct ggatatgcaa 361 caacagttga agaagaaact aaacaagaca tcttagacgt gctaattcgg tgctacctgt 421 gtcacaaacc gctgtgtgaa gtagaaaagg taaaacatat actaaccaag gcgcggttca 481 taaagctaaa ttgtacgtgg aagggtcgct gcctacactg ctggacaaca tgcatggaag 541 acatgttacc ctaaaggata ttgtattaga cctgcaacct ccagaccctg tagggttaca 601 ttgctatgag caattagtag acagctcaga agatgaggtg gacgaagtgg acggacaaga 661 ttcacaacct ttaaaacaac atttccaaat agtgacctgt tgctgtggat gtgacagcaa 721 cgttcgactg gttgtgcagt gtacagaaac agacatcaga gaagtgcaac agcttctgtt 781 gggaacacta aacatagtgt gtcccatctg cgcaccgaag acctaacaac gatggcggac 841 gattcaggta cagaaaatga ggggtctggg tgtacaggat ggtttatggt agaagctata 901 gtgcaacacc caacaggtac acaaatatca gacgatgagg atgaggaggt ggaggacagt 961 gggtatgaca tggtggactt tattgatgac agcaatatta cacacaattc actggaagca 1021 caggcattgt ttaacaggca ggaggcggac acccattatg cgactgtgca ggacctaaaa 1081 cgaaagtatt taggtagtcc atatgttagt cctataaaca ctatagccga ggcagtggaa 1141 agtgaaataa gtccacgatt ggacgccatt aaacttacaa gacagccaaa aaaggtaaag 1201 cgacggctgt ttcaaaccag ggaactaacg gacagtggat atggctattc tgaagtggaa 1261 gctggaacgg gaacgcaggt agagaaacat ggcgtaccgg aaaatggggg agatggtcag 1321 gaaaaggaca caggaaggga catagagggg gaggaacata cagaggcgga agcgcccaca 1381 aacagtgtac gggagcatgc aggcacagca ggaatattgg aattgttaaa atgtaaagat 1441 ttacgggcag cattacttgg taagtttaaa gaatgctttg ggctgtcttt tatagattta 1501 attaggccat ttaaaagtga taaaacaaca tgtttagatt gggtggtagc agggtttggt 1561 atacatcata gcatatcaga ggcatttcaa aaattaattg agccattaag tttatatgca 1621 catatacaat ggctaacaaa tgcatgggga atggtattgt tagtattatt aagatttaaa 1681 gtaaataaaa gtagaagtac cgttgcacgt acacttgcaa cgctattaaa tatacctgaa 1741 aaccaaatgt taatagagcc accaaaaata caaagtggtg ttgcagccct gtattggttt 1801 cgtacaggta tatcaaatgc cagtacagtt ataggggaag caccagaatg gataacacgc 1861 caaacagtta ttgaacacgg gttggcagac agtcagttta aattaacaga aatggtgcag 1921 tgggcgtatg ataatgacat atgcgaggag agtgaaattg catttgaata tgcacaaagg 1981 ggagattttg attctaatgc acgagcattt ttaaatagca atatgcaggc aaaatatgtg 2041 aaagattgtg caactatgtg tagacattat aaacatgcag aaatgaggaa gatgtctata 2101 aaacaatgga taaaacatag gggttctaaa atagaaggca caggaaattg gaaaccaatt 2161 gtacaattcc tacgacatca aaatatagaa ttcattcctt ttttaactaa atttaaatta 2221 tggctgcacg gtacgccaaa aaaaaactgc atagccatag taggccctcc agatactggg 2281 aaatcgtact tttgtatgag tttaataagc tttctaggag gtacagttat tagtcatgta 2341 aattccagca gccatttttg gttgcaaccg ttagtagatg ctaaggtagc attgttagat 2401 gatgcaacac agccatgttg gatatatatg gatacatata tgagaaattt gttagatggt 2461 aatcctatga gtattgacag aaagcataaa gcattgacat taattaaatg tccacctctg 2521 ctagtaacgt ccaacataga tattactaaa gaagataaat ataagtattt acatactaga 2581 gtaacaacat ttacatttcc aaatccattc ccttttgaca gaaatgggaa tgcagtgtat 2641 gaactgtcaa atacaaactg gaaatgtttt tttgaaagac tgtcgtcaag cctagacatt 2701 caggattctg aggacgagga agatggaagc aatagccaag cgtttagatg cgtgccagga 2761 acagttgtta gaactttatg aagaaaacag tactgaccta cacaaacatg tattgcattg 2821 gaaatgcatg agacatgaaa gtgtattatt atataaagca aaacaaatgg gcctaagcca 2881 cataggaatg caagtagtgc caccattaaa ggtgtccgaa gcaaaaggac ataatgccat 2941 tgaaatgcaa atgcatttag aatcattatt aaggactgag tatagtatgg aaccgtggac 3001 attacaagaa acaagttatg aaatgtggca aacaccacct aaacgctgtt ttaaaaaacg 3061 gggcaaaact gtagaagtta aatttgatgg ctgtgcaaac aatacaatgg attatgtggt 3121 atggacagat gtgtatgtgc aggacaatga cacctgggta aaggtgcata gtatggtaga 3181 tgctaagggt atatattaca catgtggaca atttaaaaca tattatgtaa actttgtaaa 3241 agaggcagaa aagtatggga gcaccaaaca ttgggaagta tgttatggca gcacagttat 3301 atgttctcct gcatctgtat ctagcactac acaagaagta tccattcctg aatctactac 3361 atacaccccc gcacagacct ccacccttgt gtcctcaagc accaaggaag acgcagtgca 3421 aacgccgcct aggaaacgag cacgaggagt ccaacagtcc ccttgcaacg ccttgtgtgt 3481 ggcccacatt ggacccgtgg acagtggaaa ccacaacctc atcactaaca atcacgacca 3541 gcaccaaaga cggaacaaca gtaacagttc agctacgcct atagtgcaat ttcaaggtga 3601 atccaattgt ttaaagtgtt ttagatatag gctaaatgac agacacagac atttatttga 3661 tttaatatca tcaacgtggc actgggcctc ctcaaaggca ccacataaac atgccattgt 3721 aactgtaaca tatgatagtg aggaacaaag gcaacagttt ttagatgttg taaaaatacc 3781 ccctaccatt agccacaaac tgggatttat gtcactgcac ctattgtaat ttgtatatat 3841 gtaaatgtgt aaatatatgg tattggtgta atacaactgt acatgtatgg aagtggtgcc 3901 tgtacaaata gctgcaggaa caaccagcac attcatactg cctgttataa ttgcatttgt 3961 tgtatgtttt gttagcatca tacttattgt atggatatct gagtttattg tgtacacatc 4021 tgtgctagta ctaacactgc ttttatattt actattgtgg ctgctattaa caaccccctt 4081 gcaatttttc ctactaactc tacttgtgtg ttactgtccc gcattgtata tacactacta 4141 tattgttacc acacagcaat gatgctaaca tgtcaattta atgatggaga tacctggctg 4201 ggtttgtggt tgttatgtgc ctttattgta gggatgttgg ggttattatt gatgcactat 4261 agagctgtac aaggggataa acacaccaaa tgtaagaagt gtaacaaaca caactgtaat 4321 gatgattatg taactatgca ttatactact gatggtgatt atatatatat gaattagagt 4381 aaaccgtttt ttatatttgt aacagtgtat gctttgtata ccatggcaca tagtagggcc 4441 cgacgacgca agcgtgcgtc agctacacag ctatatcaaa catgtaaact cactggaaca 4501 tgccccccag atgtaattcc taaggtggag cacaacacca ttgcagatca aatattaaaa 4561 tggggaagtt tgggggtgtt ttttggaggg ttgggtatag gcacgggttc cggcactggg 4621 ggtcgtactg gctatgttcc cttacaaact tctgcaaaac cttctattac tagtgggcct 4681 atggctcgtc ctcctgtggt ggtggagcct gtggcccctt cggatccatc tattgtgtct 4741 ttaattgaag aatcggcaat cattaacgca ggggcgcctg aaattgtgcc ccctgcacac 4801 ggtgggttta caattacatc ctctgaaaca actacccctg caatattgga tgtatcagtt 4861 actagtcaca ctactactag tatatttaga aatcctgtct ttacagaacc ttctgtaaca 4921 caaccccaac cacccgtgga ggctaatgga catatattaa tttctgcacc cactgtaacg 4981 tcacacccta tagaggaaat tcctttagat acttttgtgg tatcatctag tgatagcggt 5041 cctacatcca gtacccctgt tcctggtact gcacctcggc ctcgtgtggg cctatatagt 5101 cgtgcattgc accaggtgca ggttacagac cctgcatttc tttccactcc tcaacgctta 5161 attacatatg ataaccctgt atatgaaggg gaggatgtta gtgtacaatt tagtcatgat 5221 tctatacaca atgcacctga tgaggctttt atggacataa ttcgtttgca cagacctgcc 5281 attgcgtccc gacgtggcct tgtgcggtac agtcgcattg gacaacgggg gtctatgcac 5341 actcgcagcg gaaagcacat aggggcccgc attcattatt tttatgatat ttcacctatt 5401 gcacaggctg cagaagaaat agaaatgcac cctcttgtgg ctgcacagga tgatacattt 5461 gatatttatg ctgaatcttt tgaacctggc attaacccta cccaacaccc tgttacaaat 5521 atatcagata catatttaac ttccacacct aatacagtta cacaaccgtg gggtaacacc 5581 acagttccat tgtcacttcc taatgacctg tttttacaat ctggccctga tataactttt 5641 cctactgcac ctatgggaac accctttagt cctgtaactc ctgctttacc tacaggccct 5701 gttttcatta caggttctgg attttatttg catcctgcat ggtattttgc acgtaaacgc 5761 cgtaaacgta ttcccttatt tttttcagat gtggcggcct agcgacagca cagtatatgt 5821 gcctcctcct aaccctgtat ccaaagttgt tgccacggat gcttatgtta ctcgcaccaa 5881 catattttat catgccagca gttctagact tcttgcagtg ggacatcctt atttttccat 5941 aaaacgggct aacaaaactg ttgtgccaaa ggtgtcagga tatcaataca gggtatttaa 6001 ggtggtgtta ccagatccta acaaatttgc attgcctgac tcgtctcttt tcgatcccac 6061 aacacaacgt ttagtatggg catgcacagg cctagaggtg ggcaggggac agccattagg 6121 tgtgggtgta agtggacatc ctttcctaaa taaatatgat gatgttgaaa attcagggag 6181 tggtggtaac cctggacagg ataacagggt taatgtaggt atggattata aacaaacaca 6241 attatgcatg gttggatgtg cccccccttt gggcgagcat tggggtaaag gtaaacagtg 6301 tactaataca cctgtacagg ctggtgactg cccgccctta gaacttatta ccagtgttat 6361 acaggatggc gatatggttg acacaggctt tggtgctatg aattttgctg atttgcagac 6421 caataaatca gatgttccta ttgacatatg tggcactaca tgtaaatatc cagattattt 6481 acaaatggct gcagacccat atggtgatag attatttttt tttctacgga aggaacaaat 6541 gtttgccaga cattttttta acagggctgg cgaggtgggg gaacctgtgc ctgatacact 6601 tataattaag ggtagtggaa atcgcacgtc tgtagggagt agtatatatg ttaacacccc 6661 gagcggctct ttggtgtcct ctgaggcaca attgtttaat aagccatatt ggctacaaaa 6721 agcccaggga cataacaatg gtatttgttg gggtaatcaa ctgtttgtta ctgtggtaga 6781 taccacacgc agtaccaaca tgacattatg tgcatccgta actacatctt ccacatacac 6841 caattctgat tataaagagt acatgcgtca tgtggaagag tatgatttac aatttatttt 6901 tcaattatgt agcattacat tgtctgctga agtaatggcc tatattcaca caatgaatcc 6961 ctctgttttg gaagactgga actttgggtt atcgcctccc ccaaatggta cattagaaga 7021 tacctatagg tatgtgcagt cacaggccat tacctgtcaa aagcccactc ctgaaaagga 7081 aaagccagat ccctataaga accttagttt ttgggaggtt aatttaaaag aaaagttttc 7141 tagtgaattg gatcagtatc ctttgggacg caagtttttg ttacaaagtg gatatagggg 7201 acggtcctct attcgtacag gtgttaagcg ccctgctgtt tccaaagcct ctgctgcccc 7261 taaacgtaag cgcgccaaaa ctaaaaggta atatatgtgt atatgtactg ttatatatat 7321 gtgtgtatgt actgttatgt atatgtgtgt gtgtgttctg tgtgtaatgt aagttatttg 7381 tgtaatgtgt atgtgtgttt atgtgcaata aacaattacc tcttgttaca ccctgtgact 7441 cagtggctgt tgcacgcgtt ttggtttgca cgcgccttac acacataagt aatatacatg 7501 cacaatatat atatttttgt ttaaaatact atacttttat atttgcaacc gttttcggtt 7561 gcccttagca tacactttcc accaatttgt tacaacgtgt ttcctcttaa tcctatatat 7621 tttgtgccag gtacacattg ccctgccaag ttgcttgcca agtgcatcat atcctgccaa 7681 ccacacacct ggcgccaggg tgcggtattg ccttactcat aaacctgtct ttgtgttata 7741 cttttatgca ctgtagccaa ctcttaaaag catttttggc ttgtagcagc acattttttt 7801 gctcttactg tttggtatac aataacataa aaatgagtaa cctaaggtca cacacctgcg 7861 accggtttcg gttatccaca ccctacatat ttccttctta ta