LOCUS HPV61 7989 bp ds-DNA VRL 04-JUL-1995 DEFINITION Human papillomavirus type 61 (HPV61), complete genome. ACCESSION U31793 SOURCE Human papillomavirus type 61 DNA. ORGANISM Human papillomavirus type 61 Viridae; ds-DNA nonenveloped viruses; Papovaviridae; Papillomavirus. REFERENCE 1 (bases 1 to 7989) AUTHORS Delius,H. TITLE Direct Submission JOURNAL Unpublished COMMENT HPV61 has recently been characterized and isolated from a vulvar intraepithelial neoplasia by Dr. T. Matsukura (unpublished data). Cloned HPV61 DNA was obtained from the Papillomavirus Reference Center, Heidelberg and subsequently sequenced by Dr. H. Delius. A variant of HPV61 (isolate AE4) was identified in a study conducted to screen cervical lavages from over 500 women for novel HPV types (Tachezy et al, Biochem. Biophys. Res. Comm. 204, 820-827). FEATURES Location/Qualifiers CDS 102..542 /note="ORF E6 from bp 69 to 542" /product="transforming protein" /gene="E6" /note="putative" /codon_start=1 /translation="MGPCNPTNIFLLCKDYEVDFEDLRLTCVFCKNELTTEELLAFAL KELSIVWRHNWPFGVCAPCLAREVKVRELRHWDHSCYGPTVEQTTGRSLAELYIRCHA CSKPLSIQEKEHQVQAYIHFHYIAGQWTGRCCQCRGPCTARWQP" CDS 518..805 /note="ORF E7 from bp 512 to 805" /product="transforming protein" /gene="E7" /note="putative" /codon_start=1 /translation="MHGQVATIKDIVLEERPEVVDLHCNEQLLDSSESEEEDSVREQL VEQAQQAYRVVTTCGICKCPVRLVVQCGDADLKVLHELLLGDLSIVCPGCA" CDS 811..2769 /note="ORF E1 from bp 760 to 2769" /product="replication protein" /gene="E1" /note="putative" /codon_start=1 /translation="MADSEGTESGDGTEAAERAGGWFLVEAVVDRTTGYQVSSDEEDN SIDTGEDLVDFIDTRRPGDGQEVPLALFVQQNAQDDAATVQALKRKYTCSPASSTCVS LVDSELSPRLDAIRIHRGQDRARRRLFEQDSGYGHTQVEIGASESQVPGDAQHEGGGE SVQEAEEERGGGDGEAEATGNQETQAQEQAADILEVFKVSNLKAKLLYKFKDLFGLAF GELVRNFKSDKSICGDWVICAFGVYHAVAEAVKTLIQPICVYAHIQIQTCQWGMVILM LVRYKCGKSRETVAHSMGKLLNIPERQMLIEPPKIRSAPCALYWYRTAMGNASEVYGE TPEWIVRQTVVGHAMQEAQFSLSMLVQWAYDNDITDESVLAYEYALLGNEDPNAAAFL ASNCQAKYIKDAITMCKHYRRAEQAKMTMAQWITHRGRKVADTGDWKAIVKYLRYQQV EFVPFISALKLFLKGVPKKSCMVFYGPSDTGKSLFCMSLLNFLGGAVISYVNSSSHFW LSPLADTKVGLLDDATYQCWQYIDTYLRTVLDGNAISIDRKHRNLTQLKCPPLMITTN INPLEDPTFKYLHSRIVVFQFLHKCPLNSNGDPVYTLNNENWKSFFRRSWARIEGSDQ QEEEEEEDEDGVTSRPFRCVPGEITRPL" CDS 2705..3853 /note="ORF E2 from bp 2669 to 3853" /product="regulatory protein" /gene="E2" /note="putative" /codon_start=1 /translation="MRMESLADRLDACQEKLLDLYEKDSNKLEDQILHWHYVRLENAM LFKARQAGLTRVGHQMVPTLSVTKGKAHKAIEVHLSLQGLQTSAYAHEPWTLQTTSLE MWNTQPQRCWKKKGRRLTVKFDGEDHKAVEYVSWGYIYVQSTETDLWYKVPGKVSYKG LYYEMEGQEHYYVTFAQEAQKYGETGKWEVHMGNTVIYEPCASVSSTQDAVREVSTAE TAGHLRDNTTQTTTTPTCVGPTQTSTSVQTPPHKRQRLHRDREQQPDTTQKDNHKRVD STDQWINGHRNSTETGDNCDSYSSPVIHLKGDPNKLKCFRYRLQHSVPELFDKASSTW HWAGGQSTTRAAFVTLWYVNVEQRKQFLNRVTIPKGIQATAGYMSMCI" CDS <3294..3611 /note="ORF E4 from bp 3294 to 3611" /gene="E4" /note="putative" /codon_start=1 /translation="FMNPAPLYLVPRTPCEKYPLLKLLDTCGTTPHRPPPPPRAWAPP RHPPRCRRRLISDSDSTETESSSPTQHKKTTTSGWTVLTSGSTVTVTAQKQGTTVTVT VHL" CDS <3941..4210 /note="ORF E5 from bp 3941 to 4210" /gene="E5" /note="putative" /codon_start=1 /translation="TINNPGRACVFDRWMVYDTPAAYTFLAFLSFLTKRIFGVFLCHI CRIVVHIHASVVVYGITVAPPAIHCCSYVNSVPCVCCSFAICIPL" CDS 4407..5786 /note="ORF L2 from bp 4215 to 5786" /product="minor capsid protein" /gene="L2" /note="putative" /codon_start=1 /translation="MALKRRKRASATDLYRTCKQSGTCPPDVVPKVEGDTLADRILKW ASLGVFFGGLGIGTGSGTGGRTGYVPIGTRPPTVVDIGPVSRPPVVIDPVGAADPSIV TLVEESSVIEAGATVPTFSGSGGFNVTSSSTTTPAVLDITPSGGSVQVSSTSFINPLF TEPSIIEPPQAGDLAGHVISSTPTAGSHSFEEIPMHTFATSEGPGSSTPLPGIRRLAR PRLNLYSKANQQIKVANPTFMSDPASLITYDNPIFDPEETIIFEHPSIYTPPDPDFLD IVSLHRPALTSRQGTVRFSRLGQRATLRTRSGRRIGARVHFYHDISPIPSDAVELQPL VPSSSPSITYDIYADPEVLDLPAQHTQPTLTVQGPSLSAASASTKVHNVTVPLATGLD TPVTSGPDVDFAHAPAPVPAVPYVPATHPHSIYIQGSDFYLLPAYVFFPKRRKRVPYS FSDGFVAAW" CDS 5764..7281 /note="ORF L1 from bp 5593 to 7281" /product="major capsid protein" /gene="L1" /note="putative" /codon_start=1 /translation="MALWRPGDGKVYLPPTPVSKVISTDRYVQRTNLFYYGGSSRLLT VGHPYCSLQLDGLQGKKNTIPKVSGYQYRVFRVQLPDPNKFALPDGTLYNPDTERMVW ACRGIEVGRGQPLGVGTSGHPLYNRLDDTENTTLLVAESSDSRDNVSVDYKQTQLLIV GCKPPIGEHWTKGTACANPAPRPTDCPPLEFTNTTIQDGDMVETGYGAIDFAALQENK SEVPLDICTTICKYPDYLQMAAEPYGDCMFFCLRREQMFARHFFNRQGVMGEALPDSY YLKGANDKAAPGSYIYSPTPSGSMVSSDSQLFNKPYWLQRAQGHNNGICWFNELFVTV VDTTRSTNLTICTATSPPVSEYKATSFREYLRHTEEFDLQFIFQLCKIHLTPEIMAYL HNMNKALLDDWNFGVVPPPSTSLEDTYRFLQSRAITCQKGAAAPPPKEDRYAKLSFWT VDLRDKFSTDLDQFPLGRKFLLQAGPRSVSVSRKRAAPSSTPTSSPATKRKKRKQ" BASE COUNT 2113 a 1726 c 1973 g 2177 t ORIGIN 1 taacaatcat atatgtaaaa agtaggttgg caccgaaaac ggtcggaccg acctgggtac 61 atatataaag aaaccgtagg gtcagcaaag cacactcatc tatgggaccg tgcaatccaa 121 ctaatatttt cctgctctgc aaggactacg aggtggactt tgaggattta aggctgacat 181 gtgtattttg caaaaatgaa ttaacaacag aagaattgct ggcgtttgca ctaaaggagc 241 taagcattgt gtggagacat aactggccat ttggagtatg cgcaccatgc ttggcacgtg 301 aagtaaaagt gagggagctg cgacattggg accattcctg ttacggaccc actgtggaac 361 agacaacagg acggtcatta gctgaactat atatacggtg ccatgcatgc agcaaaccgt 421 taagtataca ggaaaaggag catcaggtac aggcatacat ccacttccac tatatagctg 481 gacagtggac gggaaggtgt tgccagtgta gagggccatg cacggccagg tggcaaccat 541 aaaggacata gtccttgaag agcgtcctga ggtggttgac ctacattgca atgagcagtt 601 attagacagc tcagagtcag aggaggagga tagtgtgcgt gagcaacttg ttgaacaagc 661 acagcaggcc tacagggtgg ttactacctg tggcatttgt aagtgtccag ttaggctggt 721 ggtgcagtgc ggagacgcag acctgaaggt gctacatgaa ctactgctgg gcgacttgtc 781 catagtgtgt cctggctgcg cataagggac atggctgaca gtgaaggtac agaaagcggg 841 gatgggaccg aggccgcgga acgcgcaggg gggtggtttc tggtagaagc cgtggtagac 901 cgcaccacag gataccaggt gtccagtgat gaggaggaca atagcattga cacaggggaa 961 gacctagtag acttcataga tacaaggcgc cccggggatg ggcaggaagt gccgcttgcg 1021 ttgttcgttc aacaaaatgc acaggatgac gctgcaacgg tgcaggcact aaaacgaaag 1081 tatacatgta gccctgcaag cagcacctgt gtgtccttgg tggacagtga attaagtccc 1141 cggctggacg ccatacggat acaccgggga caggacaggg ctaggagaag gctgtttgag 1201 caagatagtg gctatggcca tacgcaagtg gaaattggag catcagaaag tcaggtaccg 1261 ggggatgcgc aacatgaggg ggggggggaa tccgtgcagg aagcagagga ggagcgtggg 1321 gggggggacg gagaggccga ggccacaggt aaccaggaaa cgcaagcgca ggagcaggcg 1381 gcagacatat tagaggtgtt taaggttagt aatttaaaag caaaattact gtacaaattc 1441 aaggacctat ttggactagc atttggggag ctggtaagaa attttaaaag tgataagtca 1501 atatgtgggg actgggtaat atgtgcgttt ggtgtatacc atgctgtggc agaggctgta 1561 aaaaccttaa tacaacctat atgtgtgtat gcacacatac aaatacagac atgccagtgg 1621 ggaatggtaa tattaatgct tgtgcgatac aaatgtggga agagcaggga aacagtagca 1681 cacagcatgg gaaaactgtt aaacataccg gaaagacaga tgctaattga accaccaaag 1741 attagaagcg caccgtgcgc actatattgg tatagaacag ccatgggaaa cgccagcgag 1801 gtgtatggcg aaacacctga atggatagta agacaaacag tggtaggaca tgcaatgcaa 1861 gaagcacagt ttagtttgtc catgttagtg caatgggcat atgacaatga cataacagat 1921 gaaagtgtgc tggcctatga atatgcattg ctgggaaatg aggacccaaa tgcggcggcc 1981 ttcttggcca gtaactgcca agcaaagtat attaaagatg caattacaat gtgtaagcat 2041 tatagacgtg cagagcaggc aaaaatgaca atggcacagt ggattacaca tagaggccgc 2101 aaggtggcag acacagggga ttggaaggct attgtaaagt atttaagata tcaacaggta 2161 gaatttgtac catttattag tgcccttaaa ttgtttctaa agggggtacc aaaaaaaagc 2221 tgcatggtat tttacggacc aagcgacaca gggaagtcgc tattttgcat gagcctacta 2281 aattttctgg gaggagctgt gatttcatat gtaaattcaa gcagccattt ttggttatca 2341 cctttagcag atactaaagt gggactactg gacgatgcca cctatcagtg ctggcaatac 2401 atagatacat atttacggac agtattagat ggcaatgcca taagcataga taggaaacac 2461 agaaatttaa cacagctgaa gtgtcctcca ttaatgataa caacaaatat aaatccacta 2521 gaggatccta cgtttaaata cctgcacagt agaatagtgg tgtttcagtt tttacataag 2581 tgtccactaa acagtaatgg ggacccagta tataccctga ataatgaaaa ttggaaatca 2641 tttttccgaa ggtcctgggc acgcatagag ggatctgatc aacaggagga ggaggaggag 2701 gaggatgagg atggagtcac tagccgaccg tttagatgcg tgccaggaga aattactaga 2761 cctctatgaa aaagatagca acaagcttga ggaccaaata ttgcattggc actatgtgcg 2821 tttggaaaat gcaatgttat ttaaggcacg acaagcagga ctaacgcgtg tgggccacca 2881 gatggtgcca acacttagtg ttacaaaagg caaagcacat aaagcaattg aagtacatct 2941 gtcattgcaa gggttacaaa caagtgcata tgcgcatgaa ccctggacat tgcaaaccac 3001 ctctttggaa atgtggaata cgcagccaca acgatgctgg aagaaaaaag gacgcagact 3061 aacagttaaa tttgatggcg aggaccacaa agcagtggaa tacgttagtt gggggtatat 3121 ttatgtacaa agcacagaaa ctgatctgtg gtataaggtt cctggaaaag tgtcatataa 3181 gggcctatat tatgaaatgg agggacagga acactattat gtgacatttg cacaggaggc 3241 ccaaaaatat ggggaaacag gcaaatggga ggtacatatg ggaaacacag tgatttatga 3301 accctgcgcc tctgtatcta gtacccagga cgccgtgcga gaagtatcca ctgctgaaac 3361 tgctggacac ctgcgggaca acaccacaca gaccaccacc acccccacgt gcgtgggccc 3421 cacccagaca tccacctcgg tgcagacgcc gcctcataag cgacagcgac tccacagaga 3481 cagagagcag cagcccgaca caacacaaaa agacaaccac aagcgggtgg acagtactga 3541 ccagtggatc aacggtcacc gtaacagcac agaaacaggg gacaactgtg acagttacag 3601 ttcacctgta atacacctaa aaggtgatcc aaataaatta aagtgttttc ggtataggtt 3661 acaacattca gtacctgagc tgtttgacaa agcatcatcc acatggcatt gggccggtgg 3721 acaaagtaca accagagcag catttgtaac attgtggtat gttaatgtgg aacaacgaaa 3781 acaattttta aatcgtgtaa ccattccaaa gggtatacaa gccactgcag gctatatgtc 3841 aatgtgtata taagtgtgtg tatacaaaaa cataaatact gtgttgcaag tattgagcca 3901 gctacagcta tttacatacc acacctgcat tattgtgtaa accataaaca atcctggacg 3961 agcttgtgtg tttgatagat ggatggtgta cgatactcct gctgcttata cttttctggc 4021 tttcctatct ttcctcacta agcgcatttt tggtgttttt ctgtgccata tatgtaggat 4081 tgttgtgcat atacatgcaa gtgttgtggt atatggaata actgtggcgc caccagccat 4141 acactgctgc tcatatgtaa atagtgttcc ttgtgtctgt tgttcgtttg caatatgtat 4201 ccccttgtag ttagttcccc tcaggggttt gcattactgg ttgtggatca gcaaaactgc 4261 ggattgttat ttttgttttt gctattactg cttattgcaa tactgttgta caggctttta 4321 cattaggtgg tgtaccttgt gtgttttccc tccccacagt tttttacttt gttatatttt 4381 tatatgttta tggcctaata aacattatgg ctcttaaacg tcgcaagcgt gcatctgcaa 4441 ctgacctcta tcgtacatgt aaacaatcag gcacatgtcc ccctgatgtt gttccaaagg 4501 tggaagggga tacccttgct gaccgcattt taaagtgggc tagtttgggg gttttctttg 4561 ggggattggg tataggcacc ggctctggta ctgggggtcg tactgggtat gtgcctattg 4621 gcacccggcc tcctactgta gtggatattg gccctgtgtc ccgcccccct gtagttattg 4681 atccagtggg tgctgccgat ccctctatag ttacccttgt agaggaatcc agcgtcattg 4741 aggctggggc tacagtccct acattttccg ggtccggggg cttcaatgtc acgtcgtctt 4801 ctactaccac cccggctgtg ttggacatta ctccatcggg tgggtctgtg caggttagca 4861 gcaccagttt tattaatcct ttattcactg agccttctat tattgaacct cctcaggcag 4921 gggaccttgc cggccatgtc atttccagta cccctaccgc tgggtcccac agttttgagg 4981 aaatcccaat gcacaccttt gctacctctg agggtcctgg aagtagtacc ccgctgcctg 5041 gcatccgtcg ccttgcacgg ccccgcctga atttatacag taaggctaac caacaaatta 5101 aggttgctaa ccctacattt atgtctgatc cagcctcctt aattacatat gacaatccta 5161 tatttgatcc tgaggaaact attatatttg aacatcctag tatatataca cctcctgacc 5221 cggacttttt agatattgtg tccttacaca ggcccgcgct cacatcccgc cagggaactg 5281 tacggtttag tcgccttggt caacgtgcca ccttgcgtac ccgtagtggt aggcgcattg 5341 gcgctcgggt acacttttac catgacatta gtcccattcc atcggatgct gtggagttac 5401 agcctttggt gccgtcctcg tcccctagta taacatatga tatatatgct gaccctgagg 5461 tgttggatct tcctgcacaa catacacaac ccacacttac agtacagggc ccttccctct 5521 ctgctgcatc tgcatctacc aaggtacaca atgtcactgt tccactggcc acagggcttg 5581 atacgcctgt gacatctggc cctgatgttg attttgcaca tgctcctgcg cctgtaccag 5641 ctgtaccata tgtacctgcc acccatccac attctatata tattcagggc tctgattttt 5701 atttgttgcc tgcttatgtg ttttttccta aacgtcgtaa acgtgtaccc tattcttttt 5761 cagatggctt tgtggcggcc tggtgacggc aaggtatacc tgcctcccac tcctgtgtct 5821 aaagttatca gtactgaccg ttatgtgcaa cgcaccaact tattttatta tggtggcagt 5881 tcccgtctgc ttactgtagg acatccctat tgtagtttgc agcttgatgg gctgcagggc 5941 aagaaaaaca ctatccccaa ggtgtctggc tatcaatata gggtgtttag ggtacagctt 6001 cctgacccta ataaatttgc tttgcctgat ggcaccttgt ataatcctga tactgagcgc 6061 atggtgtggg cctgcagggg cattgaggtt ggtagggggc agccattggg ggttggtact 6121 agtggtcacc cgctgtacaa tcgcctggat gacactgaaa acaccacatt acttgttgca 6181 gagtcctctg acagtcgtga caatgtgtct gttgattata agcagaccca gctacttatt 6241 gtaggttgca aaccccctat tggggaacac tggacaaagg gtactgcttg tgctaacccc 6301 gcgccccggc ccactgactg tcctccattg gaatttacaa ataccaccat acaggatggc 6361 gatatggtgg aaacaggcta tggggccatt gattttgctg cattgcagga aaataaatct 6421 gaagtgccat tggatatttg caccactata tgcaagtatc ctgattattt acaaatggct 6481 gctgaaccat atggagactg tatgtttttt tgtttacgca gggaacaaat gtttgctcgc 6541 cactttttca atcgccaggg tgtcatgggt gaggcactgc ctgactctta ttatcttaag 6601 ggtgcgaatg acaaggcggc ccctggtagt tatatttatt cccctacgcc tagtggctct 6661 atggtgtcct ctgattccca attatttaat aagccatatt ggctgcaacg tgcccagggc 6721 cacaacaatg gtatttgttg gtttaatgaa ttgtttgtaa ccgttgtgga taccacccgc 6781 agtactaatt taaccatttg tactgctaca tccccccctg tatctgaata taaagccaca 6841 agctttaggg aatatttgcg ccatacagag gagtttgatt tgcaatttat ttttcagtta 6901 tgtaaaatac atttaacccc tgaaattatg gcctacctac ataatatgaa taaggccttg 6961 ttggatgact ggaactttgg tgtggtacca ccaccctcta ccagtttaga agacacatat 7021 aggtttttgc agtccagagc tattacatgt cagaagggtg ctgctgcccc gccgcccaag 7081 gaggatcgct atgccaagtt atccttttgg actgttgatt tacgagacaa gttttccact 7141 gatttggatc agtttccttt ggggcgcaag tttttattgc aggccggtcc ccgctcagta 7201 tctgtgtcac gcaaacgtgc tgcccccagc tctaccccta catcctcccc tgctacaaaa 7261 cgcaaaaagc gtaaacagta gtgatgtttg tctgtatgct gttgttgtgc atgtgttgtt 7321 ttgtattgtg ctgtactggc cttgtgcatg tgctgtttgt atggtgcctg gtttgtatga 7381 ctgtatttgc tatggttgtg tattgtgtga ccctgtactg acccttgtcc cctgtgttgt 7441 gtatctgtgg aatgtgtgtt acactgtgtg tgcattaata aactgtgtgt catgtgtgtg 7501 tggtgtccgg tgcaccctgt gagtaagtgt gtttattgtt gcacgcctta ttttgtgcag 7561 cttccccatt tctgtgttcc ttgtgttcgg gtagccattt tgtgttgccg accgttttcg 7621 gtctcccgcc ttttttgttg ccgaccggtt tcggtcgccc gcctttttgg ttgtggcact 7681 atgccactgt acacatacca catcctgttt aaacaaactt tatgtgttgc acctgggtgt 7741 gtttgacagg ttgctaacac acacagtttg gaacaatgct ccatctatct tttttgacat 7801 gttgtgcaat tactgtgctt ttaggcacat attttgtgct gactactttc ccttaattgc 7861 tggtttggca ttgcttgtat acttttctag ccaggaaact gtcttgcaac tttgggcatg 7921 ttttacacac attatgttac aaagccgatc cggtcgctcc ctatgtctca ttctttttat 7981 gatagttta