LOCUS HPV36 7722 bp ds-DNA VRL 04-JUL-1995 DEFINITION Human papillomavirus type 36 (HPV36), complete genome. ACCESSION U31785 SOURCE Human papillomavirus type 36 DNA. ORGANISM Human papillomavirus type 36 Viridae; ds-DNA nonenveloped viruses; Papovaviridae; Papillomavirus. REFERENCE 1 (bases 1 to 7722) AUTHORS Delius,H. TITLE Direct Submission JOURNAL Unpublished REFERENCE 2 AUTHORS Kawashima,M., Favre,M., Jablonska,S., Obalek,S., and Orth,G. TITLE Characterization of a new type of human papillomavirus (HPV) related to HPV5 from a case of actinic keratosis. JOURNAL Virology 154(2), 389-394 (1986) COMMENT DNA of HPV36 was extracted from biopsied lesions of 2 patients with actinic keratosis (AK) and molecularly cloned; 22 other patients with AK were HPV-negative by blot hybridization to a range of HPV-types. Cloned HPV36 DNA was obtained from the Papillomavirus Reference Center, Heidelberg and subsequently sequenced by Dr. H. Delius. The HPV36-positive patients were an 89 year old man (patient A) and a 61 year old man (patient B) with one lesion on the head and multiple lesions on the backs of hands and fingers respectively. Patient B also had a squamous carcinoma on the forehead. In patient B, HPV DNA was detected in only two of seven lesions of the hand and not from the sqamous carcinoma. HPV36 DNA was not detected in many other skin lesions in the general population (22 samples of Bowen's disease, 12 squamous cell carcinomas, 21 basal cell carcinomas, 8 keratoacanthomas). In contrast, HPV36 was found in 7 of 18 epidermodysplasia verruciformis (EV) patients known to be positive for HPV5 and at least one additional EV-associated type. The low rate of detection of HPV DNA in AK lesions in the general population allows for the possibility that HPV36 was not a causative factor in those AK lesions where it was detected. Nevertheless, HPV36 was the first example of an EV-associated type to be detected in an immunocompetent non-EV patient. Blot hybridization under stringent conditions revealed significant cross-hybridization only with certain EV-associated types (HPV 5,8,12,14,19-23,25); no cross-hybridization was detected with the other EV-specific HPVs (9,15,17,24), nor various non-EV cutaneous types (1-4, 7, 10, 26-29, 34), nor various mucocutaneous and mucousal types (6, 11,13,16,18,30-33,35). Phylogenetic analysis of DNA sequence indicates that HPV36 is most closely related to HPVs 5, 47, 8 and 12. FEATURES Location/Qualifiers CDS 200..673 /note="ORF E6 from bp 191 to 673" /product="transforming protein" /gene="E6" /note="putative" /codon_start=1 /translation="MAEQASEQQNITEKEKEQLPLTIKGLSESLGIPFVDCLIPCNFC GKFLDYLEACEFEVKKLSLIWKDYCVFACCRVCCGATATYEFNQFYQQTVLGRDIELA AGRSIFEIDIRCQTCLAFLDIIEKLDCCGRGLPFHRVRNAWKGICRQCKHFYNDW" CDS 663..971 /note="ORF E7 from bp 582 to 971" /product="transforming protein" /gene="E7" /note="putative" /codon_start=1 /translation="MIGKEVTVQDIVLELSEVQPEVLPVDLFCEEELPNEDTEEELDT ERIVFKVIAPCGCSHCEVKLRVFVQATEFGIRAFQQLLTGDLQLLCPECRGNCEHGGS " CDS 958..2772 /note="ORF E1 from bp 910 to 2772" /product="replication protein" /gene="E1" /note="putative" /codon_start=1 /translation="MADPKGSTSKEGFGDWCILEADCSDIENDMEQLFERDTDSDISD LIDDCDLEQGNSLELFHQQECKQSEEQLQKLKRKCLSPKAVAQLSPRLQSISLSPQQK SKRRLFAEQDSGVELTLNNEAEDVTTEVEVPAIDSRPDDEGGSGDVDIHYLSLLRSSN KKATLMAKFKAAFGVGFNELTRQFKSHKTCCNHWVVSVYAVHDDLFESSKQLLQQHCD YLWVRGIDAMSLYLLCFKAGKNRGTVHKLMTSMLNVHEQQILSEPPKLRNTAAALFWY KGCMGSGVFSYGPYPDWIAQQTILGHNNAEASTFDFSQMVQWAFDNQLVDEGDIAYRY ARLAPEDANAVAWLAHNSQAKFVRECAAMVRFYKKGQMRDMSMSEWIYTKIHEVEGEG HWSDIVKFLRYQEVNFIMFLAAFKDFLHSKPKKNCILIHGPPNSGKSSFAMSLIRVLK GRVLSFVNSKSQFWLQPLSECKIALIDDVTDPCWLYMDNYLRNGLDGHYVSLDCKYKA PMQTKFPPLLLTSNINVHEEANYRYLHSRIKGFAFPNPFPMKSDDTPQFELTDQSWKS FFERLWTQLELSDQEDEGENGESQRAFQCSAGSANEHL" CDS 2714..4243 /note="ORF E2 from bp 2684 to 4243" /product="regulatory protein" /gene="E2" /note="putative" /codon_start=1 /translation="MENLSERFNALQDLLMNIYEAAEQTLEAQIKHWQTLRQEAVLLY FARQRGVTRLGYQPVPVKAVSEAKAKEAIAMVLQLQSLQTSEYASETWTLVDTSIETF RSAPDGHFKKGPVPVEVIYDNDADNANLYTMWTYVYYMEDDVWHKARSGVNETGIYYL QGTFKYYYVLFADDARKYSQTGQWEVKVNKETVFAPVTSSTPPGSPGGQADTNASSKT STTTTATVDSTTKQLTTSEQPQQTETKGRKYGRRPSSRTRRPQAKQRRSRSRHRSSRS RSRSQSRSHTPTTRSATTRSRSPSLAKTGVQRVSTRSRSRSTSRRGGRRRRSRSPSTS SSTTTTNKRSRVRAETTGSRGARGGRGARGGSGGGRRRGRSSSSTSPAHKRSREHSVR SRGVSPDQVGKSLRSVSSKHTGRLGRLLEEALDPPVILVRGEANTLKCFRNRAKIKYM GLYRSFSTTWSWVAGDGTERLGRPRMLISFSSYNQRRDFDDVVRYPKGVEKSYGNLDS L" CDS <3273..3998 /note="ORF E4 from bp 3273 to 3998" /gene="E4" /note="putative" /codon_start=1 /translation="KLIRKLSLPLSPAPPLQGRQEDKQTQTPPPRPPPPPQPPLTPRP SSSPHQNSHNKPKPKEESTDGGPPAGQGDRKRSKGDQGPDTDPLGPDRGPSPGPTPQP LGLPPPGLGPRRSPRLGSSGYQPDHDPEAPLEGEVEGGGHGHHPPPPPPPPPTNGHEC GPKPQGPEGREGVEGPGVGAVGGGDEDDHPPPPPPPTNGQESTLLGAVACLLTKWESH FDLLVQNIQDDLEDYWKKLSIPQ" CDS 4321..5877 /note="ORF L2 from bp 4282 to 5877" /product="minor capsid protein" /gene="L2" /note="putative" /codon_start=1 /translation="MARAKRVKRDSVTHIYQTCKQAGTCPPDVVNKVEQTTVADNILK YGSAGVFFGGLGIGSGRGTGGATGYVPLSEGPGIRVGGTPTVVRPSLVPEAIGPVDIL PIDTIDPVEPTASSVVPLTESTGPDLLPGEVETIAEIHPVAEGPSVDTPVVTTSTGSS AVLEVAPEPIPPTRVRISRTQYHNPSFQIITESTPAQGESSLADHILVTSGSGGQRIG ADITDEIELQELPSRYTFENEEPTPPRRSSTPLQATRAAGRRRGVSLTNRRLVQQVPV ENPLFLTQPSRLVRFAFENPAFEEEVTNIFEHDVDAFEEPPDRDFLDVQRLGRPQYST TPAGYVRVSRLGTRATIRTRSGAQIGSQVHFYRDLSSINTEDPIELQLLGQHSGDASI VQGPVESTFIDVNVSENPLSESVEAFSDDLLLDEAVEDFSGSQLVIGNRRSTTSYTVP RFETTRSGSYYVQDSKGYYVAYPESRNNAEIIYPTPDIPVVVIHTHDNTGDFYLHPSL RWRKRKRKYL" CDS 5891..7441 /note="ORF L1 from bp 5798 to 7441" /product="major capsid protein" /gene="L1" /note="putative" /codon_start=1 /translation="MAVWHSANGKVYLPPSTPVARVQSTDEYIQRTNIYYHAFSDRLL TVGHPYFNVYDITGNKLEVPKVSGNQHRVFRLKLPDPNRFALADMSVYNPDKERLVWS CRGLEIGRGQPLGVGSTGHPLFNKLKDTENSNSYIKSSKDDRQDTSFDPKQIQMFIVG CTPCIGEHWDKAIPCEKERQDNRLCPPIELKTTYIEDGDMADIGFGNLNFKNLQESRS DVSLDIVNETCKYPDFLKMQNDVYGDACFFYARREQCYARHFFVRGGKTGDDIPDARI DNGTFKNQFFIPGADGQDQKTIGNAMYYPTVSGSLVSSDAQLFNRPFWLQRAQGHNNG ILWANQMFITVVDNTRNTNFSISIYNNNGALKDINDYTAEQFREYQRHVEEYEISLIL QLCKVPLKAEVLAQINAMNSSLLEDWQLGFVPTPDNPIQDTYRYIDSLATRCPDKTPP KEKEDPYKGLKFWDVDLTERLSLDLDQYSLGRKFLFQAGLQQTTVSGTKSVSYRGFTR GTKRKRKQ" source 1..7722 /organism="Human papillomavirus type 36" BASE COUNT 2337 a 1497 c 1773 g 2115 t ORIGIN 1 gtaagttatt taatttatgt accaggtgcg gtactggaat ttcacaataa taattgttgt 61 tgccaactac cattgctata ttcaagtttt tgcctgtatc gttttcgtat catgtgaata 121 atatactgta tagtataaat aaataaataa atatatatat atatgcttca aaggttgggt 181 tttttaataa ttaaggcaaa tggcagagca agcctccgaa cagcagaata ttacagaaaa 241 agaaaaagaa cagctgcctt taactattaa gggcctgtca gaatcattag gcattccgtt 301 tgtagactgt ctaatacctt gtaacttttg tggcaaattt ttagattatt tagaagcttg 361 tgagtttgag gttaaaaagc ttagtttaat ttggaaggat tactgtgtat ttgcctgctg 421 tcgtgtttgt tgtggtgcaa cagccacata tgagtttaat cagttttatc agcagacagt 481 attaggaaga gatattgaat tggctgcagg tcgctccata tttgaaattg acattaggtg 541 tcagacgtgc ttagcttttc ttgacataat tgagaagtta gattgttgtg gaagaggact 601 tccctttcat agagtcagaa acgcctggaa gggaatctgt aggcagtgta agcattttta 661 taatgattgg taaagaggtc accgtgcaag atattgttct ggagctcagt gaggtgcagc 721 ctgaagtact accagttgac ctgttttgtg aagaggaatt accaaacgag gatacggagg 781 aggagcttga caccgaaaga atcgttttca aagtcattgc accgtgtggt tgcagccact 841 gtgaggtcaa gctccgcgtt tttgtccaag ctacagaatt tggcatcaga gcatttcaac 901 agttgctgac cggtgacctg cagcttctgt gtcccgagtg tcgtgggaac tgcgaacatg 961 gcggatccta aaggtagtac atctaaagaa gggtttggtg attggtgtat tttggaagct 1021 gactgtagtg atatagaaaa tgatatggaa caattatttg aaagagatac agattctgat 1081 atttcggact taatagatga ttgtgacctg gaacagggaa attctttgga actatttcac 1141 caacaggagt gtaagcagag cgaggagcaa ttacaaaaac taaaacgaaa gtgtcttagt 1201 ccaaaagctg tcgcacagct tagtccgcga cttcagtcaa tttcattgtc acctcagcag 1261 aagtctaagc gaaggctctt tgcagagcag gacagcggag tcgagctgac cttaaacaat 1321 gaagctgaag atgttactac tgaggtggag gtaccggcta tagactctcg gccggatgac 1381 gagggaggat caggggatgt agatatacat tatctttcac tgttgcgttc cagcaacaaa 1441 aaagccacat taatggcaaa atttaaagca gcgtttgggg taggctttaa tgaattgaca 1501 cgtcaattca aaagtcacaa aacctgctgt aatcattggg ttgtctctgt ttatgcagtc 1561 catgatgatc tatttgaaag ttcaaagcag ttgttgcaac agcattgtga ctatttatgg 1621 gttcgtggga tagatgcaat gtcattatat ctattgtgtt ttaaggcggg aaaaaatcgc 1681 gggacagtgc ataagttgat gacttcaatg ttaaatgtgc atgaacagca gattttgtct 1741 gagcctccaa agttaagaaa tactgctgct gcattgtttt ggtacaaagg ctgtatggga 1801 tcgggggtgt tcagttatgg gccatatcct gattggattg cacaacagac tatattaggt 1861 cacaataatg ctgaagcaag cacctttgat ttttcacaga tggtacaatg ggcctttgat 1921 aatcagttag ttgatgaagg agatattgca tatcgatatg caaggcttgc accagaagat 1981 gccaatgctg ttgcatggct tgcacataat agtcaagcta aatttgtaag agagtgtgca 2041 gcaatggtgc gcttttataa aaaaggtcaa atgagggata tgtccatgtc ggaatggatc 2101 tatactaaaa tacatgaggt agaaggtgaa ggtcactggt cagatatagt aaaattttta 2161 agatatcagg aggtaaactt tataatgttt ttggctgcat tcaaagattt tttgcactca 2221 aagccaaaaa aaaattgtat tttaattcat ggccctccta attcaggaaa gtcatcattt 2281 gcaatgtcat taataagggt attaaaaggc agagtattat cttttgtaaa ttcaaaaagc 2341 caattttggt tgcaacccct ttctgaatgt aaaatagcat tgattgatga tgtaactgac 2401 ccctgttggt tatatatgga taattatcta agaaacggtt tagatgggca ttatgtctca 2461 ttggattgta aatacaaagc tccaatgcaa acaaagtttc ctccattatt actaacatct 2521 aatataaatg tgcatgagga agctaattac agatacttac acagtagaat taaaggattt 2581 gcatttccaa atccattccc aatgaaatca gacgatacac ctcagtttga gttaactgac 2641 caaagctgga aatctttttt tgaaaggctt tggacacaat tagaactcag tgaccaagaa 2701 gacgagggcg aaaatggaga atctcagcga gcgtttcaat gctctgcagg atctgctaat 2761 gaacatttat gaagctgcag aacagacact tgaggcacag ataaaacact ggcaaacctt 2821 gcgacaagaa gctgttttgc tctactttgc taggcagaga ggtgtgacaa ggcttggata 2881 tcaacctgtg cctgtaaaag ctgtatctga agcaaaagct aaagaggcta tagcaatggt 2941 gctgcagctt cagtctctac aaacgtctga atatgcatct gaaacttgga cattagttga 3001 caccagtata gaaactttta gaagcgctcc agacggtcac tttaaaaagg gtccagtgcc 3061 tgtagaagtg atttatgaca atgatgcaga taatgccaat ttgtacacta tgtggacata 3121 cgtgtattat atggaagacg atgtgtggca taaagccaga agtggggtca atgagactgg 3181 catatattat ttacaaggaa catttaaata ttactatgta ctatttgctg acgatgcacg 3241 taaatatagt caaactggac aatgggaagt gaaagttaat aaggaaactg tctttgcccc 3301 tgtcaccagc tccacccctc cagggtcgcc aggaggacaa gcagacacaa acgcctcctc 3361 caagacctcc accaccacca cagccaccgt tgactccacg accaagcagc tcaccacatc 3421 agaacagcca caacaaaccg aaaccaaagg aagaaagtac ggacggaggc cctccagcag 3481 gacaaggaga ccgcaagcga agcaaaggcg atcaaggtcc agacaccgat cctctaggtc 3541 ccgatcgcgg tcccagtccc ggtcccacac cccaaccact cggtctgcca ccacccggtc 3601 taggtccccg tcgctcgcca agactggggt ccagcgggta tcaaccagat cacgatccag 3661 aagcacctct agaaggggag gtagaaggcg gaggtcacgg tcaccatcca cctcctcctc 3721 caccaccacc accaacaaac ggtcacgagt gcgggccgaa accacagggt ccagaggggc 3781 gcgagggggt agaggggcca ggggtgggag cggtgggggg cggcgacgag gacgatcatc 3841 ctcctccacc tcccccgccc acaaacggtc aagagagcac tctgttagga gccgtggcgt 3901 gtctcctgac caagtgggaa agtcacttcg atctgttagt tcaaaacata caggacgact 3961 tggaagatta ctggaagaag ctctcgatcc cccagtgatc cttgttagag gggaggcaaa 4021 tacactaaaa tgctttcgca acagagctaa gataaaatac atgggactgt ataggtcatt 4081 tagtacaact tggtcatggg tggcaggaga tggcactgag cgtctaggca ggcccagaat 4141 gctcattagc ttttcgtcct acaatcagag aagggatttt gatgacgtgg tgagataccc 4201 gaaaggagtt gaaaaatcat atggcaacct tgacagtctc taaccactaa tgctatgctg 4261 ctttgctact aacaacacta acaaattagc tttttatact tttttacttt tgtacctgca 4321 atggcgcgtg ctaaaagggt caagcgagac tctgtaacac atatatacca gacctgcaaa 4381 caagcaggca catgcccccc tgatgttgtg aataaagtgg aacaaacaac agttgctgac 4441 aatattttga aatatggcag tgctggtgtc ttttttggtg gccttggcat tggttcgggc 4501 cgaggtactg ggggtgctac cgggtacgtg ccacttagtg aaggtcctgg tatccgtgtc 4561 ggaggtaccc ccacggttgt aaggccttca ttagttcctg aagcaattgg gccagtcgat 4621 attttgccca ttgatacaat tgatcctgtg gagcctacag catcgtccgt ggttcctctt 4681 actgaatcca ctggacctga tttacttcca ggtgaggtgg aaacaatagc tgaaattcat 4741 cctgttgctg aaggcccatc agttgatacc cctgtggtta ccacaagcac gggttccagt 4801 gctgttttgg aagttgctcc agagcctata cctccaacac gggttagaat ctcacgtaca 4861 caatatcaca atccttcctt tcaaattatt acagaatcaa cacctgcaca gggtgaaagc 4921 tctcttgcag atcacatttt agtgacatca gggtccgggg gacaaagaat aggggctgat 4981 attactgatg aaattgaact tcaagaactt cctagtagat atacttttga aaatgaagaa 5041 ccaactccac ctagacgtag cagcacacct ttacaggcca cacgagctgc aggtagacgg 5101 agaggtgttt ctttaactaa tagacgtcta gtacagcagg tacctgtaga aaatcctttg 5161 tttttaactc aaccctctcg attggtgcgt tttgcttttg aaaatcctgc atttgaagaa 5221 gaagttacaa atatatttga acatgatgta gatgcttttg aagaaccacc agatagggat 5281 tttcttgatg tccaacggtt gggtcgtccc caatattcta caactcctgc agggtatgtg 5341 agggttagta gattaggtac tcgtgcaacc attcgcacgc ggtctggtgc acaaataggg 5401 tcacaggtgc acttttatag ggatctcagt tccattaata ctgaagatcc tatagaattg 5461 cagttgttgg ggcaacattc gggggatgct agtatagttc aaggccctgt ggaaagcaca 5521 tttatagacg taaatgtgtc tgaaaatcct ttgtctgaaa gtgtggaagc cttttctgat 5581 gatttattgc tggatgaagc tgtggaggat tttagtgggt cacaattagt tattggtaat 5641 agaagaagta ccacttctta cactgttccc agatttgaaa ctactaggag tggttcttat 5701 tatgtccagg acagtaaagg atattatgtt gcatacccag aatctcgcaa taatgcagaa 5761 ataatttatc ctacacctga tatacctgta gtggtaatac acactcatga caatacaggt 5821 gacttttatt tacatcctag tcttcgatgg cgcaaacgta aaagaaaata tttgtgattt 5881 tgcattgcag atggcagtgt ggcattcggc taatggtaaa gtataccttc ctccatcgac 5941 accggttgcc agggtgcaaa gcacggatga atatatacaa aggacaaata tttattatca 6001 tgcattcagc gacagactac tgactgtagg ccatccatac ttcaatgttt acgatattac 6061 tggtaacaaa ttagaagtcc ctaaagtgtc tggtaaccaa cacagggttt ttcgcttgaa 6121 attacctgat cctaatagat ttgcattagc tgacatgtca gtttataacc cagataaaga 6181 acggttggtg tggagctgta ggggccttga aataggtaga ggacaaccgt taggtgttgg 6241 cagtacggga cacccactat ttaataagtt gaaagacact gaaaacagta attcatatat 6301 aaaatcttct aaagatgata gacaggatac atcatttgat cccaaacaaa ttcaaatgtt 6361 tatcgtggga tgcacacctt gtataggtga acattgggac aaggctatac cttgtgaaaa 6421 ggagcgccag gacaacagac tatgcccacc aattgaattg aaaactactt atatagaaga 6481 tggcgacatg gcagatatag gttttggaaa tttaaacttc aaaaatctgc aagagagtag 6541 gtcagatgta agtttggata tagttaatga aacctgcaaa tatcctgact tcttaaaaat 6601 gcagaatgat gtttatggag atgcctgttt tttttatgct cgcagagagc aatgttatgc 6661 cagacatttt tttgtccgtg gaggtaaaac gggtgacgac atccctgacg ccagaattga 6721 taatgggact tttaagaatc agtttttcat tcctggggct gacggccaag atcaaaagac 6781 cataggaaat gccatgtatt acccaactgt tagtggctca ttggtgtcta gtgatgctca 6841 attgtttaac aggcccttct ggctccagcg agcacaaggt cataataatg gcattctgtg 6901 ggctaatcag atgtttatta cagtggtaga caacacacga aatactaact ttagtatttc 6961 aatatataac aataatgggg cactaaagga catcaatgat tacactgcag agcaatttag 7021 agaatatcaa aggcacgtgg aggaatatga aatttcatta atattacagc tatgtaaggt 7081 tcctctgaag gcagaagtat tggctcagat aaatgctatg aattcttctt tattggaaga 7141 ttggcagtta ggttttgtac ctactccaga taaccctatt caagacacct atcgatatat 7201 tgattcatta gccactcgct gtcctgataa aaccccccct aaggaaaaag aggatcccta 7261 caaggggtta aagttctggg atgtggatct tactgaacgg ttgtcactag atttggatca 7321 atactcttta ggtagaaagt ttctatttca agccggctta cagcagacga ccgtaagcgg 7381 tacaaaatca gtgtcttatc gagggttcac cagaggaacc aagcgcaagc gaaaacagta 7441 atatgaccgt ttttggtaca gatttataaa cttttacaca gtattcaagg aatgtttgtt 7501 tactctgact aagtataact ctaccaaggg aaccgaccgc acccggtaca gtcaacgata 7561 ctgctgccaa tatagactct gtttagtgcc agaacatatc atcttggaag cagatcgacc 7621 gtgttcgttg taacacgctc ggattagaga cattgccaag gaagatttaa tctacaatcg 7681 ctgttggcaa tcgcttttgg ctgagatagc tgaccggtaa cg