LOCUS HPV35 7851 bp ds-DNA VRL 30-JAN-1992 DEFINITION Human papillomavirus type 35 (HPV-35), complete genome. ACCESSION M74117 KEYWORDS complete genome; major capsid protein; minor capsid protein; regulatory protein; replication protein; transformer protein. SOURCE Human papillomavirus type 35 DNA recovered from a cervical adenocarcinoma. ORGANISM Human papillomavirus type 35 Viridae; ds-DNA nonenveloped viruses; Papovaviridae; Papillomavirus. REFERENCE 1 (sites) AUTHORS Lorincz,A.T., Quinn,A.P., Lancaster,W.D. and Temple,G.F. TITLE A New Type of Papillomavirus Associated with Cancer of the Uterine Cervix JOURNAL Virology 159, 187-190 (1991) STANDARD full staff_review REFERENCE 2 (bases 1 to 7851) AUTHORS Marich,J.E., Pontsler,A.V., Rice,S.M., McGraw,K.A. and Dubensky,T.W. TITLE The phylogenetic relationship and complete nucleotide sequence of human papillomavirus type 35 JOURNAL Virology 186, 770-776 (1992) STANDARD full staff_review COMMENT In developing countries, cancer of the cervix is responsible for 24% of all cancers in women. In these areas, it is the most frequent female malignancy. In developed countries, it ranks behind cancers of the breast, lung, uterus, and ovaries and accounts for 7% of all female cancers. HPV-35 is most often found in lesions of the genital mucosa which may have a risk for malignant progression. Prevalence studies indicate that HPV-35 was present in 2/158 (1%) of anogenital intraepithelial neoplasia and in 3/69 (4%) of anogenital cancers. Thus HPV-35 is a low-prevalence HPV associated with anogenital intraepithelial neoplasia and cancer. The 7851 base pair genome of HPV-35 was first recovered from a cervical adenocarcinoma. The numbering of the sequence was determined by homology to HPV-31. Both the E6 and E7 ORFs of HPV-35 exhibit the conserved zinc finger protein motifs seen in other HPV E6 and E7 proteins. The E6 ORF also exhibits putative splice donor and acceptor sites similar to those seen in other oncogenic types (16, 18, 31, and 33). The E7 protein shows sequence homology to the adenovirus 5 E1A protein binding site for the retinoblastoma tumor suppressor gene product seen in type 16. The long control region (LCR) of HPV-35 contains features which are either conserved among all or many of the papillomaviruses or are conserved among just those associated with anogenital lesions. A feature which appears to be common among the mucosal types is the glucocorticoid response element. These elements have been shown to mediate the hormonal response in the presence of glucocorticoids. Besides the presence in HPV-35, potential GREs have been identified in types 6, 11, 16, 18, 31, 33, and 39. The author notes that their irregular distribution within the LCR raises questions concerning the premise that they play a role in the life cycle of the mucosal HPVs. In the LCR of many types, sequences homologous to binding sites for transcription factors, activator protein 1 (AP-1), and nuclear factor 1 (NF-1) have been identified. In HPV-35, two putative AP-1 regions, and five putative NF-1 regions are present. Also found in the LCR of many HPV types are tandem direct repeats, direct repeats, and inverted repeats. Like those other HPVs, HPV-35 contains tandem direct repeats of 8 bp, direct repeats of 11 bp, and inverted repeats of 7 and 8 bp. The CK-octamer motif has been identified in HPV type 6, 11, 16, 18, and 33. This element is present in HPV-35 and may explain the tissue specificity of HPV infection. Three putative E2 binding sites with the consensus ACC(Nx6)GGT have been identified in HPV-35. The author contends that these sites may not be involved with E2 binding as only 7/10 mucosal types have sequences with this consensus and that extracts of E2-transfected COS-1 cells did not protect this site in HPV 18. Of particular interest is the author's identification of a 20 bp sequence which is conserved between the oncogenic mucosal types (16, 18, 31, 33, 35, 39, and 51) and has not been found in other nononcogenic types (1a, 2a, 5, 6, 8, 9, 11, 17, 19, 20, 25, 36, 47 or 57). This 20 bp region is located approximately 30 bp 5' to the keratinocyte-specific octamer. FEATURES Location/Qualifiers 5'UTR join(7092..7851,1..109) /function="regulatory region" /standard_name="LCR" protein_bind 17..22 /bound_moiety="Sp-1" CAAT_signal complement(18..26) protein_bind 24..35 /function="gene transcription" /bound_moiety="E2" /note="putative" protein_bind 39..50 /function="gene transcription" /bound_moiety="E2" /note="putative" TATA_signal 54..59 /note="putative" CDS 110..559 /note="putative" /note="E6 ORF from bp 59 to 559" /product="transforming protein" /gene="E6" /note="putative" /codon_start=1 /translation="MFQDPAERPYKLHDLCNEVEESIHEICLNCVYCKQELQRSEVYD FACYDLCIVYREGQPYGVCMKCLKFYSKISEYRWYRYSVYGETLEKQCNKQLCHLLIR CITCQKPLCPVEKQRHLEEKKRFHNIGGRWTGRCMSCWKPTRRETEV" misc_feature 230..238 /standard_name="Splice donor" misc_feature 405..416 /standard_name="Splice acceptor" CDS 562..861 /note="putative" /product="transforming protein" /gene="E7" /note="putative" /codon_start=1 /translation="MHGEITTLQDYVLDLEPEATDLYCYEQLCDSSEEEEDTIDGPAG QAKPDTSNYNIVTSCCKCEATLRLCVQSTHIDIRKLEDLLMGTFGIVCPGCSQRA" CDS 868..2760 /note="putative" /product="replication protein" /gene="E1" /note="putative" /codon_start=1 /translation="MADPAGTDEGEGTGCNGWFFVEAVVSRRTGSSVEDENEDDCDRG EDMVDFINDTDILNIQAETETAQALFHAQEEQTHKEAVQVLKRKYASSPLSSVSLCVN NNISPRLKAICIENKNTAAKRRLFELPDSGYGNSEVEIHEIQQVEGHDTVEQCSMGSG DSITSSSDERHDETPTRDIIQILKCSNANAAMLAKFKELFGISFTELIRPFKSDKSTC TDWCVAAFGIAPSVANFKHITYVYIYNVYRVHGAMVILALLRFKVEKREQQLKTIDAK LLCISAASMLIQPPKLRSTPAALYWFKTAMSNISEVDGETPEWIQRQTVLQHSFNDAI FDLSEMVQWAYDNDFIDDSDIAYKYAQLAETNSNACAFLKSNSQAKIVKDCATMCRHY KRAEKREMTMSQWIKRRCAQVDDDGDWRDIVRFLRYQQVDFVAFLSALKNFLHGVPKK NCILIYGAPNTGKSLFGMSLMHFLQGAIISYVNSKSHFWLQPLYDAKIAMLDDATSPC GIYRPIFKKCTRWKSYISFRCKALSIVHIMPTFTYYININAGKDDRWPYLHSRVVVFT FHNEFPFDKNGNPEYGLNDKNWKSFFSRTWCRLNLHEEEVKENDGDAFPAFKCVSGQN TRTLRD" CDS 2693..3796 /function="regulation of gene expression" /note="putative" /product="regulatory protein" /gene="E2" /note="putative" /codon_start=1 /translation="MMETLSQRLSVCQDKILEHYETDSTCLSDHIQYWKLIRLECAVF YKAREMGIKTLNHQVVPTQAISKAKAMQAIELQLMLETLNTTEYSTEDWTLQETSIEL YTTVPTRCLKKDVYTVEAQFDGDKQNTMHYTNWTHIYILEDSICTVVKGLVNYKGIYY VHQGVETYYVTFREEAKKYGKKNIWEVHVGGQVIVCPESVFSSTELSTAEIATQLHAY NTTETHTKACSVGTTETQKTNHKRLRGGTELPYNPTKRVRLSAVDSVDRGVYSTSDCT NKDRCGSCSTTTPIVHLKGDANTLKCSRYRLGKYKALYQDASSTWRWTCTNDKKQIAI VTLTYTTEYQRDKFLTTVKIPNTVTVSKGYMSI" CDS <3273..3563 /note="putative" /gene="E4" /note="putative" /codon_start=1 /translation="LFVLNLYLAAQNYPLLKLLHSYTPTTPPRPIPKPAPWAPQKPRR QITNDFEGVPSSPTTPPSECDSVPWTVLTEGSTLHLTAQTKTGVVVVVQLHL" /partial CDS 3793..4038 /note="putative" /gene="E5" /note="putative" /codon_start=1 /translation="MIDLTASSTVLLCFLLCFCVLLCLCLLVRSLLLSVSLYSALILL VLILWVTVATPLLAFVVSCFCIYLWMINAHAQYLAVQ" polyA_signal 4159..4164 /note="putative" CDS 4184..5593 /note="putative" /product="minor capsid protein" /gene="L2" /note="putative" /codon_start=1 /translation="MRHKRSTKRVKRASATQLYRTCKAAGTCPPDVIPKVEGNTVADQ ILKYGSMAVFFGGLGIGSGSGTGGRSGYVPLGTTPPTAATNIPIRPPVTVESIPLDTI GPLDSSIVSLVEETSFIESGAPVVTPRVPPTTGFTITTSTDTTPAILDVTSISTHDNP TFTDPSVLHPPTPAETSGHFVLSSSSISTHNYEEIPMDTFIVSTDSNNITNSTPIPGS RPTTRLGLYSKGTQQVKVVDPAFMTSPAKLITYDNPAYEGLNPDTTLQFEHEDISLAP DPDFMDIIALHRPALTSRKGTIRYSRVGNKRTMHTRSGKAIGARVHYYQDLSSITEDI ELQPLQHVPSSLPHTTVSTSLNDGMFDIYAPIDTEEDIIFSASSNNTLYTTSNTAYVP SNTTIPLSSGYDIPITAGPDIVFNSNTITNSVLPVPTGPIYSIIADGGDFYLHPSYYL LKRRRKAIPYFFADVSVAV" CDS 5574..7091 /note="putative" /product="major capsid protein" /gene="L1" /note="putative" /codon_start=1 /translation="MSLWRSNEATVYLPPVSVSKVVSTDEYVTRTNIYYHAGSSRLLA VGHPYYAIKKQDSNKIAVPKVSGLQYRVFRVKLPDPNKFGFPDTSFYDPCLQRLVWAC TGVEVGRGQPLGVGISGHPLLNKLDDTENLNKYVGNSGNSGTDNRECISMDYKQTQLC LIGCRPPIGEHWGKGTPCNANQVKAGECPPLELLNTVLQDGDMVDTGFGAMDFTTLQA NKSDVPLDICSSICKYPDYLKMVSEPYGDMLFFYLRREQMFVRHLFNRAGTVGETVPA DLYIKGTTGTLPSTSYFPTPSGSMVTSDAQIFNKPYWLQRAQGHNNGICWSNQLFVTV VDTTRSTNMSVCSAVSSSDSTYKNDNFKEYLRHGEEYDLQFIFQLCKITLTADVMTYI HSMNPSILEDWNFGLTPPPSGTLEDTYRYVTSQAVTCQKPSAPKPKDDPLKNYTFWEV DLKEKFSADLDQFPLGRKFLLQAGLKARPNFRLGRRAAPASTSKKSSTKRRKVKS" repeat_region 7090..7105 /rpt_unit=7090..7097, 7098..7105 repeat_region 7123..7160 /rpt_unit=7123..7133, 7150..7160 protein_bind 7415..7426 /function="gene transcription" /bound_moiety="E2" /note="putative" protein_bind 7477..7491 /bound_moiety="hormone receptor" /standard_name="glucocorticoid responsive element" protein_bind 7514..7519 /bound_moiety="NF-1" protein_bind 7527..7532 /bound_moiety="NF-1" protein_bind 7534..7539 /bound_moiety="NF-1" enhancer complement(7670..7677) /standard_name="keratinocyte specific enhancer (CK-octomer)" /note="putative" protein_bind 7671..7676 /bound_moiety="NF-1" protein_bind 7695..7700 /bound_moiety="NF-1" source 1..7851 /organism="Human papillomavirus type 35" /proviral /sequenced_mol="DNA" /tissue_type="cervical carcinoma" BASE COUNT 2553 a 1343 c 1568 g 2387 t ORIGIN 1 ccctataaaa aaaacaggga gtgaccgaaa acggtcgtac cgaaaacggt tgccataaaa 61 gcagaagtgc acaaaaaagc agaagtggac agacattgta aggtgcggta tgtttcagga 121 cccagctgaa cgaccttaca aactgcatga tttgtgcaac gaggtagaag aaagcatcca 181 tgaaatttgt ttgaattgtg tatactgcaa acaagaatta cagcggagtg aggtatatga 241 ctttgcatgc tatgatttgt gtatagtata tagagaaggc cagccatatg gagtatgcat 301 gaaatgttta aaattttatt caaaaataag tgaatataga tggtatagat atagtgtgta 361 tggagaaacg ttagaaaaac aatgcaacaa acagttatgt catttattaa ttaggtgtat 421 tacatgtcaa aaaccgctgt gtccagttga aaagcaaaga catttagaag aaaaaaaacg 481 attccataac atcggtggac ggtggacagg tcggtgtatg tcctgttgga aaccaacacg 541 tagagaaacc gaggtgtaat catgcatgga gaaataacta cattgcaaga ctatgtttta 601 gatttggaac ccgaggcaac tgacctatac tgttatgagc aattgtgtga cagctcagag 661 gaggaggaag atactattga cggtccagct ggacaagcaa aaccagacac ctccaattat 721 aatattgtaa cgtcctgttg taaatgtgag gcgacactac gtctgtgtgt acagagcaca 781 cacattgaca tacgtaaatt ggaagattta ttaatgggca catttggaat agtgtgcccc 841 ggctgttcac agagagcata atctacaatg gctgatcctg caggtacaga tgaaggggag 901 gggacgggat gtaatggatg gttttttgta gaagcagtag ttagtagacg tacgggatcc 961 agtgtagagg acgaaaatga agatgactgt gacagggggg aggatatggt ggactttata 1021 aatgatacag atatattaaa catacaggca gaaacagaga cagcacaagc attatttcat 1081 gcacaggagg agcaaacaca caaagaggct gtacaggtcc taaaacgaaa gtatgctagt 1141 agtccactta gcagcgtgag cttatgtgtt aataataaca taagtccacg tttaaaagct 1201 atttgcattg aaaataaaaa tacagcagca aagcgacgat tatttgaact accagacagc 1261 ggttatggca attctgaagt ggaaatacac gagatacaac aggtagaggg gcatgataca 1321 gttgaacaat gtagtatggg cagtggggat agtataacct ctagtagcga tgaaagacat 1381 gatgagactc caacgcgaga cataatacaa atactaaaat gtagtaatgc aaacgcagct 1441 atgttggcta aatttaaaga actatttggt attagtttta cagaacttat tagaccattt 1501 aagagtgata aatccacatg tacagattgg tgtgtggccg catttggaat agccccaagt 1561 gtggcgaact ttaaacatat aacatatgta tacatataca atgtttatcg tgttcatggg 1621 gctatggtaa ttctagcatt attacgattt aaagtcgaaa aacgagaaca acaattgaaa 1681 actattgatg ctaaattgct atgtatttca gctgcaagta tgctaataca accaccaaaa 1741 ttacgtagta ccccagctgc gttatattgg tttaaaacag caatgtcaaa tattagtgag 1801 gttgatggag aaacaccaga atggattcaa agacaaacag tattacagca tagttttaat 1861 gatgcaatat ttgacctatc tgaaatggta caatgggcat atgacaatga ttttatagat 1921 gatagtgata tagcatataa atatgcacaa ttggcagaaa ctaatagtaa tgcatgtgct 1981 tttttaaaaa gtaattcgca agctaaaatt gtaaaagatt gtgcaacaat gtgtagacat 2041 tataaacgag ctgaaaaaag agaaatgaca atgtcacagt ggattaaaag gcgatgtgca 2101 caggtggacg atgacggtga ctggagggac atagtacgat ttttaagata tcaacaagta 2161 gattttgtgg catttttatc tgcactaaaa aattttttac atggtgtgcc taaaaaaaat 2221 tgcatactaa tatatggagc accaaacaca ggtaaatcat tatttggaat gagtctaatg 2281 catttcttac aaggagctat tatatcctat gtaaattcta aaagccattt ttggttgcag 2341 ccattatatg atgccaaaat agctatgtta gatgatgcta catcgccatg tggcatatat 2401 agaccaatat ttaagaaatg cactagatgg aaatcctata tttcatttag atgtaaagca 2461 ttaagcatag tgcatataat gcccaccttt acttattaca tcaatataaa tgcaggcaaa 2521 gatgacaggt ggccatactt acatagcagg gtagtggtct ttacatttca caatgaattc 2581 ccatttgata aaaatggaaa cccagagtat gggcttaatg ataaaaactg gaaatccttt 2641 ttctcaagga cgtggtgcag attaaatttg cacgaggaag aggtcaaaga aaatgatgga 2701 gacgctttcc cagcgtttaa gtgtgtgtca ggacaaaata ctagaacatt acgagactga 2761 tagcacatgt ttgtctgatc acatacagta ttggaaactg attcgtcttg aatgtgcagt 2821 attttataaa gcaagagaaa tgggaattaa aactcttaac caccaagtgg ttccaacgca 2881 ggccatttca aaagccaaag caatgcaagc aattgaactg caattaatgt tagagacatt 2941 aaatacaact gagtatagca cagaggactg gacactgcaa gaaacaagta ttgaactata 3001 tacaacagtt cctacaagat gtttaaaaaa agatgtttat actgtggaag cacaatttga 3061 tggtgataaa caaaatacta tgcattatac taattggaca catatatata tattagagga 3121 cagtatatgt actgttgtaa agggactggt aaattataaa ggtatttatt atgtgcatca 3181 gggtgtagaa acatattatg ttacttttag ggaagaggct aaaaagtatg gaaaaaaaaa 3241 tatatgggaa gtgcatgtgg gtggtcaggt aattgtttgt cctgaatctg tatttagcag 3301 cacagaacta tccactgctg aaattgctac acagctacac gcctacaaca ccaccgagac 3361 ccataccaaa gcctgctccg tgggcaccac agaaacccag aagacaaatc acaaacgact 3421 tcgagggggt accgagctcc cctacaaccc caccaagcga gtgcgactca gtgccgtgga 3481 cagtgttgac agaggggtct actctacatc tgactgcaca aacaaagacc ggtgtggtag 3541 ttgtagtaca actacaccta tagtacattt aaaaggtgat gcaaatacat taaagtgttc 3601 aagatataga ttgggtaaat ataaagcatt gtatcaagat gcttcatcta catggagatg 3661 gacatgtaca aacgataaaa aacaaatagc aattgtaaca ttaacttaca caacagaata 3721 tcaaagggat aaatttttaa ctacagtaaa aatacctaac acagttacag tgtctaaagg 3781 atatatgtct atatgataga ccttacagct tccagtactg tgttgctgtg ctttttgttg 3841 tgcttttgtg tgcttttgtg cttgtgtctg cttgtacgtt cgctattgct atctgtgtca 3901 ttatactcag cattaatatt actggtttta atactgtggg ttactgtagc aacaccacta 3961 cttgcttttg ttgtttcttg cttttgtata tacctatgga tgattaacgc tcatgcacaa 4021 tatttggcag tacagtaatt gtatacaaac attgtgtttg gtactgtgta acatgtgtgt 4081 atggtggttt tattttttgt tgttcattgt atattttgtt tttttactgt ttttaaacat 4141 ttttatttct gtgtttttaa taaattgatc acatggtata accatgcgac acaaaaggtc 4201 tacaaaacgt gttaaacgtg catctgcaac acaactatat cgtacttgca aagctgcagg 4261 aacttgtcca ccagatgtta tacctaaggt tgagggtaat actgttgctg atcaaatttt 4321 aaaatatggc agcatggctg tgttttttgg ggggttagga attggttctg gatctggcac 4381 aggtggaaga tctggatatg ttccactggg tacaacacct ccaacggctg ccacaaacat 4441 tcctatacga ccccctgtaa ctgtggaaag tataccatta gacacaattg gccctttaga 4501 ttcttctata gtgtcattag tagaggaaac tagttttatt gagtctggtg cccctgttgt 4561 tacaccaagg gtcccaccta caacaggttt tacaataacc acatctacag ataccacacc 4621 tgctatttta gatgtgacat ccataagtac acatgataat cctactttca ctgatccttc 4681 tgttttacac ccacccacgc ctgcagaaac ttcaggtcat tttgtacttt catcatcttc 4741 tattagtaca cataattatg aagaaatccc tatggatact tttattgttt ccacagacag 4801 caataatata actaatagca cgcctattcc agggtctcgc cctacgacac gcctaggatt 4861 atatagtaaa ggtacccagc aggttaaggt tgttgaccct gcctttatga cttctcctgc 4921 aaaacttatt acatatgata atcctgcata tgaaggcctt aaccctgata caaccttaca 4981 atttgagcat gaggatatta gcttagctcc ggatcctgac tttatggaca ttatagcttt 5041 acataggcct gcactaacat ctaggaaagg cactattaga tatagtagag taggtaataa 5101 acgtactatg catacacgaa gtggaaaagc tataggggca cgggtacatt attatcagga 5161 tttaagtagt attactgaag atatagaatt acaaccctta caacatgtac catcctcttt 5221 accacatacc actgtttcaa catcattaaa tgatggtatg tttgatattt atgctcctat 5281 agatactgag gaagatatta tattttcagc atcttctaac aatactttat atactacatc 5341 taacactgca tatgttccta gcaatactac tataccatta agtagtggct atgatattcc 5401 tataacagca gggccagaca ttgtatttaa ctctaatact attactaact ctgtactacc 5461 ggtacccaca ggtcctatat attctattat tgcagatggg ggtgactttt atttacaccc 5521 tagttattat ttattaaaac gacgtcgtaa agctatccca tatttttttg cagatgtctc 5581 tgtggcggtc taacgaagcc actgtctacc tgcctccagt gtcagtgtct aaggttgtta 5641 gcactgatga atatgtaaca cgcacaaaca tctactatca tgcaggcagt tctaggctat 5701 tagctgtggg tcacccatac tatgctatta aaaaacaaga ttctaataaa atagcagtac 5761 ccaaggtatc tggtttgcaa tacagagtat ttagagtaaa attaccagat cctaataagt 5821 ttggatttcc agacacatca ttttatgatc cctgcctcca gcgtttggtt tgggcctgta 5881 caggagttga agtaggtcgt ggtcagccat taggagtagg tattagtggt catcctttat 5941 taaataaatt ggatgatact gaaaatctta ataaatatgt tggtaactct ggtaactctg 6001 gtacagataa cagggaatgc atttctatgg attataaaca aacacaattg tgtttaatag 6061 gttgtaggcc tcctataggt gaacattggg gaaaaggcac accttgtaat gctaaccagg 6121 taaaagcagg agaatgtcct cctttggagt tactaaacac tgtactacaa gacggggaca 6181 tggtagacac aggatttggt gcaatggatt ttactacatt acaagctaat aaaagtgatg 6241 ttcccctaga tatatgcagt tccatttgca aatatcctga ttatctaaaa atggtttctg 6301 agccatatgg agatatgtta tttttttatt tacgtaggga gcaaatgttt gttagacatt 6361 tatttaatag ggctggaact gtaggtgaaa cagtacctgc agacctatat attaagggta 6421 ccactggcac attgcctagt actagttatt ttcctactcc tagtggctct atggtaacct 6481 ccgatgcaca aatatttaat aaaccatatt ggttgcaacg tgcacaaggc cataataatg 6541 gtatttgttg gagtaaccaa ttgtttgtta ctgtagttga tacaacccgt agtacaaata 6601 tgtctgtgtg ttctgctgtg tcttctagtg acagtacata taaaaatgac aattttaagg 6661 aatatttaag gcatggtgaa gaatatgatt tacagtttat ttttcagtta tgtaaaataa 6721 cactaacagc agatgttatg acatatattc atagtatgaa cccgtccatt ttagaggatt 6781 ggaattttgg ccttacacca ccgccttctg gtaccttaga ggacacatat cgctatgtaa 6841 catcacaggc tgtaacttgt caaaaaccca gtgcaccaaa acctaaagat gatccattaa 6901 aaaattatac tttttgggag gttgatttaa aggaaaagtt ttctgcagac ttagatcagt 6961 ttccgttggg ccgtaaattt ttgttacaag caggactaaa ggccaggcct aattttagat 7021 taggcaggcg tgcagctcca gcatctacat ctaaaaaatc ttctactaaa cgtagaaaag 7081 taaaaagtta atgtgtaaat gtgtatgcat gtatactgtg tgttatgtgt tgtagtgctt 7141 gtatatatat tatgtgttgt ggtgcctgtt tgtgttgtac atggcgtgta aatgtgtgta 7201 taatattgtg caatgtgttg tacgtgggtg tttttgtact tagtgtgtag tagttcagta 7261 gccataaagt gatgtgtgtg tttataatta acactgtatt gttgtatgac tatggtgcac 7321 cgatatgagc ttacataatt acatgacagc tatattgtgt atataaataa tctacctcca 7381 ttttgtgtgt tagtgtcctt tacattacct ttcaaccgat ttcggttgct gttggtaagc 7441 tttatatgtt ttttacaaaa acattcctac ctcagcagaa cacttaatcc ttgtgttcct 7501 gatatatatt gtttgccaac tttatattgg cttttgccaa tctttaaact tgattcatct 7561 tgcagtatta gtcatttttc atacttgtgg tccacccaca cttgtaacac ttgtaacagt 7621 gcttttaggc acatattttt tgcatttcta aagggcttta attgcacacc ttggctttac 7681 atattatgtg tgtttgccaa caccacccta cacatcctgc caactttaag ttaaaacatg 7741 catgtaaaac attactcact gtattacaca ttgttatatg cacacaggtg tgtccaaccg 7801 atttggatta cagttttata agcatttctt tttattatag ttagtaacaa t