LOCUS HPV13 7880 bp ds-DNA VRL 01-DEC-1992 DEFINITION Human papilloma virus type 13 (HPV-13), complete genome. ACCESSION X62843 KEYWORDS genome. SOURCE Human papillomavirus type 13 DNA recovered from FEH lesions from a 13 year old Turkish girl. ORGANISM Human papillomavirus type 13 Viridae; ds-DNA nonenveloped viruses; Papovaviridae; Papillomavirus. REFERENCE 1 (bases 1 to 7880) AUTHORS van Ranst,M., Fuse,A., Fiten,P., Beuken,E., Pfister,H., Burk,R.D. and Opdenakker,G. TITLE Human papillomavirus type 13 and pygmy chimpanzee papillomavirus type 1: Comparison of the genome organizations JOURNAL Virology 190, 587-596 (1992) STANDARD full staff_review COMMENT HPV13 belongs to a subgroup of orogenital papillomaviruses (including also HPV6, HPV11, HPV43, HPV44) associated as a group with benign orogenital lesions (FEH, condyloma acuminata and low-grade cervical neoplasia), and only rarely with cervical cancer. In addition to its similarity to other HPVs, HPV-13 has been shown to be 85% homologous to a pigmy chimpanzee papillomavirus (PCPV-1) cloned from a colony of pigmy chimpanzees afflicted by a FEH-like disease. This close relationship may indicate the possibility of cross-species transmission. HPV13 itself is associated primarily with oral focal epithelial hyperplasia (FEH). FEH is characterized by multiple and discrete nodular elevations of the oral mucosa. Its prevalence is high in Indians in Central and South America and in Eskimos in Greenland and Alaska, but is low in Caucasians who live in the same area. Recently, HPV-13 has been detected by PCR in a case of low-grade cervical dysplasia and by in situ hybridization in Bowenoid papulosis in an HIV-positive male. In both of these instances, HPV16 was also present in the lesion. The authors of [1] contend that the discovery of HPV13 in these recent cases along with the relative rarity of FEH in the Caucasian population to which the subjects belonged may point to the existence of a hidden reservoir of virus in this population. The complete genome of HPV-13 was cloned from the FEH lesions of a 13-year-old Turkish girl. The sense strand, containing all ORF's of significant length, is shown, with the first position of the circular genome defined by homology with HPV6 and HPV11. The E6 ORF of HPV-13 contains four copies of the cysteine doublet motif. This protein may be involved with the binding of p53. Also this ORF, as is the case with types 6, 11, and 44, do not contain the splice acceptor/donor pair which seems to be critical for E7 expression. The E7 ORF of HPV-13 contains a degenerate form of the cell division motif which may mediate binding of the tumor suppressor protein pRB-105. In the beginning of the E2 ORF, HPV-13 contains a leucine zipper motif. This motif has been found to be degenerate in the high-risk papillomaviruses. It has been speculated that this motif in an E2 activator protein could help to mediate the binding of this activator to the URR, which blocks transcription of E6. The upstream regulatory region (URR) contains several promoter elements and transcription factors: TATA box at nt 68, CAAT signal at nt 9, 5 NF-1 binding sites at 7587, 7607, 7717, 7741, and 7761, 2 AP-1 binding sites at 7404 and 7810, Oct-1 binding site at 7324, and 4 copies of the E2 binding region. Unlike other genital papillomaviruses, HPV-13 does not house a glucocorticoid response element. Thus, it may not be influenced by steroid hormones. FEATURES Location/Qualifiers 5'UTR join(7242..7880,1..103) /function="regulatory region" /standard_name="LCR" CAAT_signal 9..14 /note="putative" protein_bind 36..47 /function="gene transcription" /bound_moiety="E2" /note="putative" protein_bind 52..63 /function="gene transcription" /bound_moiety="E2" /note="putative" TATA_signal 68..73 /note="putative" CDS 104..556 /note="ORF E6 from bp 53 to 556" /product="transforming protein" /gene="E6" /note="putative" /codon_start=1 /translation="MESANASTPAKTIDQLCKECNLSMHSLQILCVFCRKTLSTAEVY AFQYKSLYIVWRGQFPFAACACCLEIQGKINQFRHFDFAGFAVTVEEDTKQSILDVLI RCYLCHKPLCEVEKLRHILQKARFIKLNSSWKGRCFHCWSSCMENILP" CDS 532..837 /note="ORF E7 from bp 487 to 837" /product="transforming protein" /gene="E7" /note="putative" /codon_start=1 /translation="MHGKYPTLKDIVLELTPDPVGLHCNEQLDSSEDEVDEQATQATQ ATQHSTLLQCYQILTSCSKCCSNVRLVVECTGPDIHDLHDLLLGTLNIVCPLCAPKS" CDS 843..2783 /note="ORF E1 from bp 765 to 2783" /product="replication protein" /gene="E1" /note="putative" /codon_start=1 /translation="MAEDTGTNNEGTGCSGWFLVEAVVERTTGQQISDDEDETVEDSG LDMVDFIDDRPITHNSVEAQALLNEQEADAHYAAVQDLKRKYLGSPYVSPLGHVEQSV DCDISPRLDAIKLSRNSKKVKRRLFQSREITDSGYGYSEVEAETQVERNGEPENDCGG GGHGRDKEGEGQVHTEVHTGSQIEEHTGTTRVLELLKCKDVRATLYGKFKDCYGLSFT DLIRPFKSDKTTCGDWVVAAFGIHHSVSEAFEKLMQPLTTYMHIQWLTNAWGMVLLVL IRFKVNKSRCTVARTLATFLNIPEDHMLIEPPKIQSSVAALYWFRTGISNASIVTGET PEWIKRQTIVEHGLADNQFKLTEMVQWAYDNDFCDESEIAFEYAQRGDFDSNARAFLN SNCQAKYVKDCATMCKHYKNAEMKKMSMKQWITYRSKKIEEAGNWKPIVQFLRHQNIE FIPFLSKLKLWLHGTPKKNCIAIVGPPDTGKSCFCMSLIKFLGGTVISYVNSSSHFWL QPLCNAKVALLDDATQSCWVYMDTYMRNLLDGNPMSIDRKHKSLALIKCPPLLVTSNV DITKDDKYKYLYSRVTTLTFPNPFPFDRNGNAVYELSDANWKCFFTRLSASLDIQDSE DEDDGDNSQAFRCVPGTVVRTV" CDS 2725..3858 /note="ORF E2 from bp 2698 to 3858" /product="regulatory protein" /gene="E2" /note="putative" /codon_start=1 /translation="METIAKHLDACQEQLLELYEENSNELKKHIQHWKCLRYESVLLH KARQMGLSHIGLQVVPPLTVSQAKGHEAIEMQMTLETLLESEFGMEPWTLQDTSREMW LTPPKRCFKKQGQTVEVKYDCNTDNRMDYVSWTYIYVFDTDKWTKVKGMVDYKGLYYI HGNLKTYYLEFEKEAKKYGETLQWEVCIGSTVICSPASVSSTVQEVSIAGPASYSTTT STQASTAVSCSASEECVQAPPCKRQRGPSRPIGNPQNTQSIVCVTDYDTLDSANNNIN VNHYNNNKGRDNSYCAATPIVQLQGDSNCLKCFRYRLHEKYKDLFLLASSTWHWTAPN NSQKHALVTLTYVNEQQRQDFLKTVKIPPTITHKLGFMSLQLL" CDS 3257..3613 /note="ORF E4 from bp 3233 to 3613" /gene="E4" /note="putative" /codon_start=1 /translation="MGKRYNGKYVLAAQSYVLLHLYLVLYKKYPLLGLLHTPPPPPHR PPPQCPAAPRKNVCKRRLVNDNEDLHVPLETPRTHKALCVSQTTTPWTVQTTTSTLTI TTITKDGTTVTVQLHL" CDS 3908..4183 /note="ORF E5 from bp 3908 to 4183" /gene="E5" /note="putative" /codon_start=1 /translation="MEFIPVDVSTQATSKSLLPLVIALTVCVVSIITILCISEFLVYT NVLVLTLILYVLLWLLLTTPLQFYLLTLSLCFLPALCVHQYILQTQE" CDS 4364..5755 /note="ORF L2 from bp 4331 to 5755" /product="minor capsid protein" /gene="L2" /note="putative" /codon_start=1 /translation="MAHSRARRRKRASATQLYQTCKASGTCPPDVIPKVEQNTLADKI LKWGSLGVFFGGLGIGTGSGTGGRTGYVPVGSTPRPAISTGPTARPPIVVDTVGPTDP SIVSLVEESAIINSGVPDPLPPVHGGFEITTSQSATPAILDVSVTTQNTTSTSIFRNP VFSEPSITQSQPSIESGAHVFISPSTISPHSTEDIPLDTFIVSSSDSNPASSTPVPAT VARPRLGLYSRALHQVQVTDPAFLSSPQRLITFDNPTYEGEDISLQFAHNTIHEPPDE AFMDIIRLHRPAITSRRGLVRFSRIGQRGSMYTRSGKHIGGRVHFFKDISPISAAAEE IELHPLVAAAQDHSGLFDIYAEPDPDPVAVNTSGSLSSASTPFAQSSLSSAPWGNTTV PLSLPGDIFIQPGPDITFPTAPTVTPYNPVTPALPTGPVFITASGFYLYPTWYFTRKR RKRVSLFFTDVAA" polyA_signal 4495..4500 /note="putative" CDS 5742..7241 /note="ORF L1 from bp 5613 to 7241" /product="major capsid protein" /gene="L1" /note="putative" /codon_start=1 /translation="MWRPSDNKLYVPPPAPVSKVITTDAYVTRTNIFYHASSSRLLAV GNPYFPIKKQNKTVVPKVSGYQFRVFKVVLPDPNKFALPDTSIFDSTSQRLVWACTGL EVGRGQPLGVGISGHPLLNKYDDVENSASYAANPGQDNRVNVAMDYKQTQLCLVGCAP PLGEHWGQGKQCTGVNVQPGDCPPLELISSVIQDGDMVDTGFGAMNFAELQSNKSDVP LDICTSTCKYPDYLQMAADPYGDRLFFYLRKEQMFARHFFNRAGSVGEQIPAELYVKG SNTLSNSIYYNTPSGSLVSSEAQLFNKPYWLQKAQGHNNGICWGNHLFVTVVDTTRST NMTVCAATTSSLSDTYKATEYKQYMRHVEEFDLQFIFQLCTIKLTAEVMSYIHTMNPT ILEDWNFGLSPPPNGTLEDTYRYVQSQAITCQKPTPDKEKQDPYAGLSFWEVNLKEKF SSELDQYPLGRKFLLQTGVQSRSPIRVGRKRAASTSTATPTTRKKAKRK" protein_bind 7324..7331 /bound_moiety="Oct-1" /note="putative" polyA_site 7369..7374 /note="putative" protein_bind 7404..7410 /bound_moiety="AP-1" /note="putative" protein_bind 7513..7524 /function="gene transcription" /bound_moiety="E2" /note="putative" protein_bind 7587..7592 /bound_moiety="NF-1" /note="putative" protein_bind 7607..7612 /bound_moiety="NF-1" /note="putative" protein_bind 7717..7722 /bound_moiety="NF-1" /note="putative" protein_bind 7741..7746 /bound_moiety="NF-1" /note="putative" protein_bind 7761..7766 /bound_moiety="NF-1" /note="putative" protein_bind 7810..7816 /bound_moiety="AP-1" /note="putative" protein_bind 7838..7849 /function="gene transcription" /bound_moiety="E2" /note="putative" source 1..7880 /organism="Human papillomavirus type 13" /sequenced_mol="DNA" BASE COUNT 2452 a 1480 c 1628 g 2320 t ORIGIN degenerate HpaI site; 103 bp upstream from beginning of E6 cds 1 gtttctaaca atcttaagtt taaaaaatag gtgggaccga aaacggtttt aaccgaaaac 61 ggtgatatat aaaccagccc aaaaattgag caagcggggc ataatggaaa gtgcaaatgc 121 ctccacgcct gcaaaaacta tagaccagtt gtgcaaggag tgcaaccttt ctatgcacag 181 cttgcaaatt ctatgcgtgt tctgcaggaa aaccctgtcc acggcagagg tttatgcatt 241 tcagtataag agtttatata tagtgtggcg aggacagttt ccatttgcgg cttgtgcatg 301 ctgcttagaa atacaaggaa agattaacca gtttaggcat tttgacttcg cgggatttgc 361 tgtaacagtt gaagaagaca caaagcagtc aattttggat gtgctaattc gctgctattt 421 atgccacaaa ccattgtgtg aagtggagaa actaagacat attttgcaga aggcacgatt 481 tattaaatta aacagcagtt ggaaaggccg ctgttttcat tgctggtcat catgcatgga 541 aaatatccta ccttaaaaga cattgtttta gagctgactc ctgaccctgt aggtctacat 601 tgcaatgagc aattagacag ctcagaagac gaggtggacg aacaagccac gcaagccacg 661 caagccacgc aacatagcac actattacaa tgctaccaaa tactaacgtc ctgtagtaaa 721 tgttgtagca acgtccggct ggtggtggag tgtacaggac ctgacattca cgacctacac 781 gacctactgc tgggcacgct gaatatagtg tgccctttgt gtgcaccaaa aagctaacca 841 cgatggcaga ggatacaggt actaataatg aggggacggg atgctcagga tggtttttag 901 tagaggctgt agtagaacga acaactgggc aacaaatatc agatgatgag gatgaaacag 961 tggaagatag tgggttggat atggtggatt tcatagatga cagacctatt acacacaatt 1021 ccgtggaagc acaggcattg ttaaacgagc aggaggcgga tgctcattat gcggctgtgc 1081 aggacctaaa acgaaagtat ttaggcagtc catatgttag tcccctagga catgttgaac 1141 agtcagtgga ctgtgatata agtcctcgat tggacgctat aaaattaagt agaaattcta 1201 aaaaagtaaa gcgacggctg tttcaatcaa gggaaataac ggacagtgga tatggctatt 1261 ctgaagtgga agctgaaacg caggtagaga gaaatggcga accggaaaat gattgtgggg 1321 gtggtggaca cggaagggac aaagaggggg agggacaggt gcacacggaa gtgcacacag 1381 gcagccagat agaagagcac acagggacca cgcgggtgtt agaactcctt aaatgtaagg 1441 atgtaagggc tacattgtat ggtaagttta aagactgtta tgggttatca tttacagatt 1501 taattagacc atttaaaagt gataaaacaa catgtgggga ctgggtggtt gcagcatttg 1561 gtatacatca tagtgtatca gaggcatttg aaaagttaat gcagccatta acaacatata 1621 tgcatataca atggcttaca aatgcatggg ggatggtatt gttagtatta ataagattta 1681 aagtaaataa aagtagatgc acagtggcgc gaacactggc aacctttctt aatattcctg 1741 aggaccacat gttaattgaa cctcccaaaa tacaaagcag tgtggcagca ttatactggt 1801 ttagaacagg tatttctaat gctagtatag taactggtga aacaccagaa tggataaaaa 1861 ggcaaacaat tgtagagcat ggacttgcag ataatcaatt taaattaact gaaatggtgc 1921 agtgggcata tgataatgat ttttgtgatg aaagcgaaat agcatttgaa tatgcacaac 1981 gaggagattt tgattcaaat gccagggcat ttttaaatag taattgtcag gcaaaatatg 2041 taaaagattg tgcaacaatg tgcaagcatt ataaaaatgc agaaatgaaa aaaatgtcta 2101 tgaaacaatg gataacatat agaagtaaaa aaatagagga agcaggaaat tggaaaccaa 2161 tagtacaatt tttaaggcat caaaatatag aatttattcc atttttaagt aaattaaaat 2221 tgtggcttca tggcacgcca aagaaaaact gtattgcaat agtggggcca ccagatacag 2281 gcaaatcatg tttttgcatg agcttaatta agtttttagg gggcacagta attagttatg 2341 taaattcaag tagccatttt tggctgcagc cattatgtaa tgcaaaggta gctttgctag 2401 atgatgcaac gcagtcatgc tgggtatata tggacacata catgagaaat ttattagatg 2461 gcaatccaat gagcattgat agaaaacata agtctttagc attaataaaa tgtccgccat 2521 tattagtaac atctaatgta gacattacca aagatgacaa atataaatat ttgtatagta 2581 gagtaacaac acttacattt ccaaatccat tcccttttga cagaaatggg aatgcagtat 2641 atgagttgtc tgatgcaaac tggaaatgtt tttttacaag attgtcagca agcctagata 2701 tacaggactc tgaggacgag gacgatggag acaatagcca agcatttaga tgcgtgccag 2761 gaacagttgt tagaactgta tgaagaaaat agtaatgaac ttaaaaaaca tatacaacat 2821 tggaaatgct taaggtacga aagtgtactc ttacacaaag cacgccaaat gggcctaagc 2881 cacattggat tacaagtggt gccaccattg acagtatcac aagctaaggg acatgaggca 2941 attgaaatgc aaatgacttt agagacatta ctagagtctg agtttggtat ggaaccatgg 3001 actttacaag atacaagtcg tgaaatgtgg ctaacacccc caaaacgctg ttttaagaaa 3061 cagggacaaa ctgtggaagt aaaatatgac tgtaatacag acaatagaat ggattatgtg 3121 tcgtggacat acatatatgt gtttgacaca gataaatgga caaaggtgaa aggaatggta 3181 gattataaag ggttgtacta catacatgga aatttgaaaa catattattt agagtttgaa 3241 aaggaggcta aaaaatatgg ggaaacgtta caatgggaag tatgtattgg cagcacagtc 3301 atatgttctc ctgcatctgt atctagtact gtacaagaag tatccattgc tgggcctgct 3361 tcatactcca ccaccacctc cacacaggcc tccaccgcag tgtcctgcag cgcctcggaa 3421 gaatgtgtgc aagcgccgcc ttgtaaacga caacgaggac cttcacgtcc cattggaaac 3481 ccccagaaca cacaaagcat tgtgtgtgtc acagactacg acaccctgga cagtgcaaac 3541 aacaacatca acgttaacca ttacaacaat aacaaaggac gggacaacag ttactgtgca 3601 gctacaccta tagttcaatt acaaggtgac tctaattgtc taaagtgttt tcgatataga 3661 ttacatgaaa aatataaaga tttatttttg ttagcatcat ctacatggca ttggaccgcc 3721 cctaataatt cacaaaaaca tgcactggta accttaacct atgtaaatga acaacaaaga 3781 caagactttt taaaaactgt aaaaatacct ccaaccataa cacataaact aggttttatg 3841 tcattgcaat tgttataaca gcatatattg tatgtaaata tttgttgtgt gtgtgtatat 3901 attgtaaatg gaatttatac ctgtggatgt tagtacacag gcaaccagca agtcattact 3961 gccacttgta attgcactta cagtgtgtgt agttagcatt ataacaatat tgtgcatatc 4021 agagttcttg gtgtacacaa acgttttagt actaacatta attttatatg tacttttgtg 4081 gcttttacta acaactccct tgcaattcta tttactaacc ctgtctcttt gctttcttcc 4141 tgcgttgtgt gtacaccaat atattttaca aacacaagaa taactataca caatgttaac 4201 ctgtactttt gatgatggtg acacatggtt gctattatgg ttaattttat catttattgt 4261 agccattcta gggttactgt tgctgtatat aagaactgga catatgcatt gccagtgctg 4321 gagtaaataa gtggttttat attttgtgtg tattcattta attatggcac atagtagggc 4381 tcgcagacgc aaacgcgctt cagctacaca actatatcaa acttgtaagg cttctggaac 4441 atgtcctcct gatgttatac caaaggttga acaaaacact cttgcagata aaatattaaa 4501 gtggggcagt ttaggagtat tttttggggg gcttggcatt ggcacaggct ctggtactgg 4561 cggtaggact ggctatgtac cagtaggatc caccccacgc cctgccatat caactgggcc 4621 tactgcacgt cctcctattg ttgttgatac tgttgggcct acagaccctt ctattgtatc 4681 tttggtagag gaatcagcta ttattaattc tggagtacct gaccctttgc ctcccgttca 4741 tgggggtttt gaaatcacca catctcaatc agccactcca gcaatattgg atgtgtctgt 4801 tacaacacaa aacactacgt ccacaagtat atttagaaat cctgtttttt cagaaccttc 4861 tattacacaa tctcaacctt ctattgaaag tggtgcacac gtgtttatat cgccatctac 4921 tatttcccct cattctacag aagacattcc tttagataca tttattgtat cttcctcaga 4981 tagtaatcct gcatcaagca cccctgttcc agcaactgtt gcacgtccac gtctaggcct 5041 ttacagtagg gccttacatc aagtacaggt tactgatcct gcctttttat cgtcgcccca 5101 acgccttata acctttgata accctacata tgaaggtgaa gatataagtt tgcagtttgc 5161 acacaatacc attcatgaac cccctgatga ggcatttatg gatattataa gactacatag 5221 gccagccata acatcacggc gtggtcttgt taggtttagt agaattggtc agagggggtc 5281 tatgtatact cgaagcggca agcatatagg tggaagggtc catttcttta aggatatttc 5341 tcctatatct gcagctgcag aagaaataga attacacccc cttgtggctg ctgcacagga 5401 tcacagtggt ttgtttgata tttatgcaga acctgaccct gaccctgtgg ctgtaaacac 5461 ctctgggtca ttgtcttctg cctccacacc atttgcacaa tcttctttgt cttccgcccc 5521 atggggtaat actactgttc ctctttcact accaggtgat atatttatac agcctggtcc 5581 tgacataaca ttcccaactg cacctacagt aacgccttat aatcctgtta cgcctgcttt 5641 acctacaggt cctgttttta ttactgcttc tggattttat ttatatccta catggtattt 5701 tacacgcaaa cgccgtaaac gtgtttcctt gttttttaca gatgtggcgg cctagtgaca 5761 acaaactata tgtgcctcct cccgcccctg tatcaaaagt aattactacg gatgcctatg 5821 ttacacgtac caacatattt tatcatgcta gcagttctag actacttgca gtgggaaatc 5881 cttattttcc tattaagaaa caaaacaaaa ctgttgtccc taaggtatct ggttatcagt 5941 ttagggtatt taaagttgta ttacctgacc ctaataaatt tgccctgcct gacacatcta 6001 tatttgactc aactagtcaa cgcttagtgt gggcctgtac aggtttagag gttggtaggg 6061 gtcaaccctt aggtgttggt attagtggtc atccattatt aaataaatat gatgatgtgg 6121 aaaattctgc aagttatgct gccaatcctg gtcaggataa tagggttaat gtggccatgg 6181 actataaaca aacacagtta tgtttagtgg gctgtgcacc tcctttaggt gaacattggg 6241 gacagggcaa gcaatgtact ggtgtaaatg tacaacctgg agattgccct cctttagaat 6301 taattagtag tgtaattcag gatggtgaca tggtggatac aggatttgga gccatgaatt 6361 ttgcggaatt gcaatctaat aaatctgatg tgccactaga catatgcacg tccacatgca 6421 aatatcctga ctatttacaa atggctgcgg atccttatgg agacagatta tttttttatc 6481 tgcgaaagga acaaatgttt gcaaggcatt tctttaacag ggcaggctct gttggtgaac 6541 aaatcccagc agaattatat gttaagggta gtaatacact ttctaatagt atttactata 6601 atactcccag tggctctctt gtgtcttctg aggcccagtt gtttaataaa ccttattggt 6661 tacaaaaggc ccagggacac aataatggta tatgttgggg caatcacttg tttgttactg 6721 tagttgatac tacacgcagt actaacatga ctgtgtgtgc agccactaca tcatctcttt 6781 cagacacata taaggccaca gaatataaac agtacatgcg acatgtagaa gaatttgatt 6841 tacaatttat ttttcaattg tgcactatta aattaactgc agaggttatg tcatatattc 6901 atactatgaa tcctacaatt ctagaagact ggaactttgg gctatctccc cctcctaatg 6961 gaacattaga agacacatat agatatgtac aatctcaggc cataacgtgt caaaagccta 7021 cacctgataa agaaaaacag gatccgtatg cgggtcttag tttttgggag gttaatctta 7081 aggaaaagtt ttctagtgaa ctagatcagt atccccttgg cagaaagttt ttattacaaa 7141 caggcgttca gtctaggtcc cctattcgtg taggtaggaa acgtgctgca tctacatcta 7201 ctgccacacc tactacacgt aaaaaagcta aaaggaaata atagtttgtt tatgattgtg 7261 tatgtatgtc acgtttgttt gtactgtatg tatgttgtgt actgtatgtg taatgttgta 7321 tgtatgtgca tgttacttat taaagaatgt gtgtgtgtgt ttgtatgcaa taaatctaat 7381 ctgtggtgtc ctgttccacc ctatgagtaa gtggtatgtt gtgtctcgtg tggtgttttg 7441 tatactatac tataacatta gtgcaaccat tttgtaactt ttcttacatt ttacgtctcc 7501 atattaagtg caaccgattt cggttgctat tgtttctgcg accgatttgt tgcagcacgc 7561 tgtttatata atcttaccta ccgcctgcca aaattatcca ccgcttgcca aaatcaccca 7621 cacacctggc gttgctaggg cgcggttata tatatttact aaatcttact aatctttcta 7681 tcactcattt tacctttata acaatacttt tgcttttcaa gtacattttt gtacttacta 7741 gccaatgcct gaaaggtttt ttggctacca gcactacatt tttgtacagt taatgttaca 7801 tgtataaaat gagtaaccta aggtcacaca cctgcaaacc ggtatcggtt aaaacacacc 7861 ctctatagtt ccttataatt