LOCUS p107Rb 3960 bp ss-mRNA PRI 06-MAY-1993 DEFINITION Human retinoblastoma related protein (p107) mRNA, complete cds. ACCESSION L14812 KEYWORDS cell cycle regulation protein; retinoblastoma protein; tumor suppressor. SOURCE Homo sapiens cDNA to mRNA. ORGANISM Homo sapiens Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (sites) AUTHORS Ewen,M.E., Xing,Y., Bentley-Lawrence,J. and Livingston,D.M. TITLE Molecular cloning, chromosome mapping and expression of the cDNA for p107 a retinoblastoma gene product-related protein JOURNAL Cell 66, 1155-1164 (1991) STANDARD full staff_review REFERENCE 2 (bases 1 to 3960) AUTHORS Zhu,L., van den Heuvel,S., Helin,K., Fattaey,A., Ewen,M., Livingston,D., Dyson,N. and Harlow,E. TITLE Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein JOURNAL Genes Dev. (1993) In press STANDARD full staff_review FEATURES Location/Qualifiers CDS 69..3275 /map="20q11.2" /product="p107" /codon_start=1 /translation="MFEDKPHAEGAAVVAAAGEALQALCQELNLDEGSAAEALDDFTA IRGNYSLEGEVTHWLACSLYVACRKSIIPTVGKGIMEGNCVSLTRILRSAKLSLIQFF SKMKKWMDMSNLPQEFRERIERLERNFEVSTVIFKKYEPIFLDIFQNPYEEPPKLPRS RKQRRIPCSVKDLFNFCWTLFVYTKGNFRMIGDDLVNSYHLLLCCLDLIFANAIMCPN RQDLLNPSFKGLPSDFHTADFTASEEPPCIIAVLCELHDGLLVEAKGIKEHYFKPYIS KLFDRKILKGECLLDLSSFTDNSKAVNKEYEEYVLTVGDFDERIFLGADAEEEIGTPR KFTRDTPLGKLTAQANVEYNLQQHFEKKRSFAPSTPLTGRRYLREKEAVITPVASATQ SVSRLQSIVAGLKNAPSDQLINIFESCVRNPVENIMKILKGIGETFCQHYTQSTDEQP GSHIDFAVNRLKLAEILYYKILETVMVQETRRLHGMDMSVLLEQDIFHRSLMACCLEI VLFAYSSPRTFPWIIEVLNLQPFYFYKVIEVVIRSEEGLSRDMVKHLNSIEEQILESL AWSHDSALWEALQVSANKVPTCEEVIFPNNFETGNGGNVQGHLPLMPMSPLMHPRVKE VRTDSGSLRRDMQPLSPISVHERYSSPTAGSAKRRLFGEDPPKEMLMDKIITEGTKLK IAPSSSITAENVSILPGQTLLTMATAPVTGTTGHKVTIPLHGVANDAGEITLIPLSMN TNQESKVKSPVSLTAHSLIGASPKQTNLTKAQEVHSTGINRPKRTGSLALFYRKVYHL ASVRLRDLCLKLDVSNELRRKIWTCFEFTLVHCPDLMKDRHLDQLLLCAFYIMAKVTK EERTFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNINDDFEMIDCDLEDATK TPDCSSGPVKEERSDLIKFYNTIYVGRVKSFALKYDLANQDHMMDAPPLSPFPHIKQQ PGSPRRISQQHSIYISPHKNGSGLTPRSALLYKFNGSPSKSLKDINNMIRQGEQRTKK RVIAIDSDAESPAKRVCQENDDVLLKRLQDVVSERANH" source 1..3960 /organism="Homo sapiens" /sequenced_mol="cDNA to mRNA" BASE COUNT 1257 a 771 c 869 g 1063 t ORIGIN 1 cgggtagcgc gcctgggagg gagaaagaag tcgggggccg tggcgcgcag cccgcggggc 61 ctgaagggat gttcgaggac aagccccacg ctgagggggc ggcggtggtc gccgcagccg 121 gggaggcgct acaggccctg tgccaggagc tgaacctgga cgaggggagc gcggccgaag 181 ccctggacga ctttactgcc atccgaggca actacagcct agagggagaa gttacacact 241 ggttggcatg ttcattatat gttgcatgcc gcaaaagcat tattcccacg gttggaaagg 301 gtatcatgga aggcaactgt gtttcactta ccagaatact acgttcagct aaattaagtt 361 taatacaatt ttttagtaaa atgaagaaat ggatggacat gtcaaatcta ccacaagaat 421 ttcgtgaacg tatagaaagg ctagagagaa attttgaggt gtctactgta atattcaaaa 481 aatatgagcc aattttttta gatatatttc aaaatccata tgaagaacca ccaaagttac 541 cacgaagccg gaagcagagg aggattcctt gcagtgttaa ggatctgttt aatttctgtt 601 ggacactttt tgtttatact aagggtaatt ttcggatgat tggggatgac ttagtaaact 661 cttatcattt acttctatgc tgcttggatc tgatttttgc caatgcgatt atgtgcccaa 721 atagacaaga cttgctaaat ccatcattta aaggtttacc atctgatttt catactgctg 781 actttacggc ttctgaagag ccaccctgca tcattgctgt actgtgtgaa ctgcatgatg 841 gacttctcgt agaagcaaaa ggaataaagg agcactactt taagccatat atttcaaaac 901 tctttgacag gaagatatta aaaggagaat gcctcctgga cctttcaagt tttactgata 961 atagcaaagc agtgaataag gagtatgaag agtatgttct aactgttggt gattttgatg 1021 agaggatctt tttgggagca gacgcagaag aggaaattgg aacacctcga aagttcactc 1081 gtgacacccc attagggaaa ctgacagcac aggctaatgt ggagtataac cttcaacagc 1141 actttgaaaa aaaaaggtca tttgcacctt ctaccccact gaccggacgg agatatttac 1201 gagaaaaaga agcagtcatt actcctgttg catcagccac ccaaagtgtg agccggttac 1261 agagtattgt ggctggtctg aaaaatgcac caagtgacca acttataaat atttttgaat 1321 cttgtgtgcg taatcctgtt gaaaacatta tgaaaatact aaaaggaata ggagagactt 1381 tctgtcaaca ctatactcaa tcaacagatg aacagccagg atctcacata gactttgctg 1441 taaacagact aaagctggca gaaattttgt attataaaat actagagact gtaatggttc 1501 aggaaacacg aagacttcat ggaatggaca tgtcagttct tttagagcaa gatatatttc 1561 atcgttcctt gatggcttgt tgtttggaaa ttgtgctctt tgcctatagc tcacctcgta 1621 cttttccttg gattattgaa gttctcaact tgcaaccatt ttacttttat aaggttattg 1681 aggtggtgat ccgctcagaa gaggggctct caagggacat ggtgaaacac ctaaacagca 1741 ttgaagaaca gattttggag agtttagcat ggagtcacga ttctgcactg tgggaggctc 1801 tccaggtttc tgcaaacaaa gttcctacct gtgaagaagt tatattccca aataactttg 1861 aaacaggaaa tggaggaaat gtgcagggac atcttcccct gatgccaatg tctcctctaa 1921 tgcacccaag agtcaaggaa gttcgaactg acagtgggag tcttcgaaga gatatgcaac 1981 cattgtctcc aatttctgtc catgaacgct acagttctcc taccgcaggg agtgctaaga 2041 gaagactctt tggagaggac cccccaaagg aaatgcttat ggacaagatc ataacagaag 2101 gaacaaaatt gaaaatcgct ccttcttcaa gcattactgc tgaaaatgta tcaattttac 2161 ctggtcaaac tcttctaaca atggccacag ccccagtaac aggaacaaca ggacataaag 2221 ttacaattcc attacatggt gtcgcaaatg atgctggaga gatcacactg atacctcttt 2281 ccatgaatac aaatcaggag tccaaagtca agagtcctgt atcacttact gctcattcat 2341 taattggtgc ttctccaaaa cagaccaatc tgactaaagc acaagaggta cattcaactg 2401 gaataaacag gccaaagaga actgggtcct tagcactatt ttacagaaag gtctatcatt 2461 tggcaagtgt acgcttacgt gatctatgtc taaaactgga tgtttcaaat gagttacgaa 2521 ggaagatatg gacgtgtttt gaattcactt tagttcactg tcctgatcta atgaaagaca 2581 ggcatttgga tcagctcctc ctttgtgcct tttatatcat ggcaaaggta acaaaagaag 2641 aaagaacttt tcaagaaatt atgaaaagtt ataggaatca gccccaagct aatagtcacg 2701 tatatagaag tgttctgctg aaaagtattc caagagaagt tgtggcatat aataaaaata 2761 taaatgatga ctttgaaatg atagattgtg acttagaaga tgctacaaaa acacctgact 2821 gttccagtgg accagtgaaa gaggaaagaa gtgatcttat aaaattttac aatacaatat 2881 atgtaggaag agtgaagtca tttgcactga aatacgactt ggcgaatcag gaccatatga 2941 tggatgctcc accactctct ccttttccac atattaaaca acagccaggc tcaccacgcc 3001 gcatttccca gcagcactcc atttatattt ccccgcacaa gaatgggtca ggccttacac 3061 caagaagcgc tctgctgtac aagttcaatg gcagcccttc taagagtttg aaagatatca 3121 acaacatgat aaggcaaggt gagcagagaa ccaagaagcg agtaatagcc atcgatagtg 3181 atgcagaatc ccctgccaaa cgcgtctgtc aagaaaatga tgacgtttta ctgaaacgac 3241 tacaggatgt tgtcagtgaa agagcaaatc attaatgttg ttcttgtttc tatgataaaa 3301 gcactttcag attgttctgc agaaagttgg agctctgtcc ttcaaacctt ttagccctat 3361 agatgataaa tatcactggg ttataagaaa aaattgcaca aaaattatgt gctttttaaa 3421 atatttatcc aaaatgtagt tgacagagat gtattttgag ttggattgga aaggaatatt 3481 ttaagtgcct tttaaaaata ctaatagtcc ggccaggcgc tgtggctcac gcctctaatc 3541 ccaggacttt gggaggccaa ggcgggcaga tcaccggagt caggagttcg agaccagcct 3601 gaccaacatg gagaaacccc atctctacta aaaatacaaa attagccggg tggtgtggcg 3661 catgcctata atcccagcta cttgggaggc tgaggcagaa ttgcttgaac ccaggaagcg 3721 gaggttgtgg tgagccaagg ttgcgccact gcactccagc ctgggcaaca agagtaaaac 3781 tccatctcaa aaaatatata tatatatata aatagggaat tttttttaat gtttgctcct 3841 tgagttttca agatgaaata aggagaaacc ccataacttt ttagctctct tttaaaaata 3901 aatgtctcct tctgtgttct gtaatatgag gataaataat ctgcttttga tagcaaaaaa //