LOCUS c-myc 8082 bp ds-DNA PRI 10-AUG-1992 DEFINITION Human (Lawn) c-myc proto-oncogene, complete coding sequence and flanks. ACCESSION J00120 KEYWORDS Alu repeat; c-myc proto-oncogene; myc oncogene; proto-oncogene; repeat region; transforming gene. SOURCE Human DNA (genomic library of Lawn et al.), clones lambda-M1 [1], and pUC9-myc [2]. ORGANISM Homo sapiens Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 3507 to 7559) AUTHORS Colby,W.W., Chen,E.Y., Smith,D.H. and Levinson,A.D. TITLE Identification and nucleotide sequence of a human locus homologous to the v-myc oncogene of avian myelocytomatosis virus MC29 JOURNAL Nature 301, 722-725 (1983) STANDARD full staff_review REFERENCE 2 (bases 1 to 8082) AUTHORS Gazin,C., Dupont,S., de Dinechin,D., Hampe,A., Masson,J.M., Martin,P., Stehelin,D. and Galibert,F. TITLE Nucleotide sequence of the human c-myc locus: provocative open reading frame within the first exon JOURNAL EMBO J. 3, 383-387 (1984) STANDARD full staff_review COMMENT The myc gene is the cellular homologue of the transforming gene carried by the avian myelocytomatosis virus MC29. Unlike the ras proto-oncogenes which obtain transforming potential through mutations within their coding exons (namely mutations within codon 12), the myc gene identified as the cause of Burkitt lymphomas acquires its transforming potential through defects of either transcriptional or translational control. Thus it is not an altered gene product that induces tumors, but a normal product that is present either in the wrong quantity or at the wrong time in the life cycle of the cell. [2] notes an open reading frame upstream of the c-myc coding exons with an 'atg' start codon at bases 2304-2306 and a 'tag' stop codon at bases 2868-2870. However other researchers have used c-myc and v-myc DNA sequences to probe for mRNA's with homology to c-myc in various human cell lines and none of them have noted any mRNA's beginning upstream of bp 2328 (see other human c-myc entries). The t(8;14) translocation site in the Burkitt lymphoma cell line BL22 occurs between bp 1316 and 1317 of this sequence. See other human c-myc entries. FEATURES Location/Qualifiers prim_transcript 2328..7526 /note="c-myc mRNA (alt.)" prim_transcript 2502..7526 /note="c-myc mRNA (alt.)" intron 2882..4505 /note="c-myc mRNA intron a" exon 4521..5277 /number=1 CDS join(4521..5277,6654..7215) /note="c-myc protein, first translated" /gene="MYC" /map="8q24" /codon_start=1 /translation="MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPA PSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMV TELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSG SPNPARGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSP SSDSLLSSTESSPQGSPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKR SESGSPSAGGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLR QISNNRKCTSPRSSDTEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPK VVILKKATAYILSVQAEEQKLISEEDLLRKRREQLKHKLEQLRNSCAX" /partial intron 5278..6653 /note="c-myc cds intron b" repeat_region 6299..6466 /note="human Alu-like repeat" exon 6654..7215 /number=2 source 1..8082 /organism="Homo sapiens" /sequenced_mol="DNA" BASE COUNT 1850 a 2115 c 2135 g 1982 t ORIGIN 198 bp upstream of Sau96A site, on chromosome 8 (q24). 1 agcttgtttg gccgttttag ggtttgttgg aatttttttt tcgtctatgt acttgtgaat 61 tatttcacgt ttgccattac cggttctcca tagggtgatg ttcattagca gtggtgatag 121 gttaattttc accatctctt atgcggttga atagtcacct ctgaaccact ttttcctcca 181 gtaactcctc tttcttcgga ccttctgcag ccaacctgaa agaataacaa ggaggtggct 241 ggaaacttgt tttaaggaac cgcctgtcct tcccccgctg gaaaccttgc acctcggacg 301 ctcctgctcc tgcccccacc tgacccccgc cctcgttgac atccaggcgc gatgatctct 361 gctgccagta gagggcacac ttactttact ttcgcaaacc tgaacgcggg tgctgcccag 421 agagggggcg gagggaaaga cgctttgcag caaaatccag catagcgatt ggttgctccc 481 cgcgtttgcg gcaaaggcct ggaggcagga gtaatttgca atccttaaag ctgaattgtg 541 cagtgcatcg gatttggaag ctactatatt cacttaacac ttgaacgctg agctgcaaac 601 tcaacgggta ataacccatc ttgaacagcg tacatgctat acacacaccc ctttcccccg 661 aattgttttc tcttttggag gtggtggagg gagagaaaag tttacttaaa atgcctttgg 721 gtgagggacc aaggatgaga agaatgtttt ttgtttttca tgccgtggaa taacacaaaa 781 taaaaaatcc cgagggaata tacattatat attaaatata gatcatttca gggagcaaac 841 aaatcatgtg tggggctggg caactagctg agtcgaagcg taaataaaat gtgaatacac 901 gtttgcgggt tacatacagt gcactttcac tagtattcag aaaaaattgt gagtcagtga 961 actaggaaat taatgcctgg aaggcagcca aattttaatt agctcaagac tccccccccc 1021 ccccaaaaaa aggcacggaa gtaatactcc tctcctcttc tttgatcaga atcgatgcat 1081 tttttgtgca tgaccgcatt tccaataata aaaggggaaa gaggacctgg aaaggaatta 1141 aacgtccggt ttgtccgggg aggaaagagt taacggtttt tttcacaagg gtctctgctg 1201 actcccccgg ctcggtccac aagctctcca cttgcccctt ttaggaagtc cggtcccgcg 1261 gttcgggtac cccctgcccc tcccatattc tcccgtctag cacctttgat ttctcccaaa 1321 cccggcagcc cgagactgtt gcaaaccggc gccacagggc gcaaagggga tttgtctctt 1381 ctgaaacctg gctgagaaat tgggaactcc gtgtgggagg cgtgggggtg ggacggtggg 1441 gtacagactg gcagagagca ggcaacctcc ctctcgccct agcccagctc tggaacaggc 1501 agacacatct cagggctaaa cagacgcctc ccgcacgggg ccccacggaa gcctgagcag 1561 gcggggcagg aggggcggta tctgctgctt tggcagcaaa ttgggggact cagtctgggt 1621 ggaaggtatc caatccagat agctgtgcat acataatgca taatacatga ctccccccaa 1681 caaatgcaat gggagtttat tcataacgcg ctctccaagt atacgtggca atgcgttgct 1741 gggttatttt aatcattcta ggcatcgttt tcctccttat gcctctatca ttcctcccta 1801 tctacactaa catcccacgc tctgaacgcg cgcccattaa tacccttctt tcctccactc 1861 tccctgggac tcttgatcaa agcgcggccc tttccccagc cttagcgagg cgccctgcag 1921 cctggtacgc gcgtggcgtg gcggtgggcg cgcagtgcgt tctctgtgtg gagggcagct 1981 gttccgcctg cgatgattta tactcacagg acaaggatgc ggtttgtcaa acagtactgc 2041 tacggaggag cagcagagaa agggagaggg tttgagaggg agcaaaagaa aatggtaggc 2101 gcgcgtagtt aattcatgcg gctctcttac tctgtttaca tcctagagct agagtgctcg 2161 gctgcccggc tgagtctcct ccccaccttc cccaccctcc ccaccctccc cataagcgcc 2221 cctcccgggt tcccaaagca gagggcgtgg gggaaaagaa aaaagatcct ctctcgctaa 2281 tctccgccca ccggcccttt ataatgcgag ggtctggacg gctgaggacc cccgagctgt 2341 gctgctcgcg gccgccaccg ccgggccccg gccgtccctg gctcccctcc tgcctcgaga 2401 agggcagggc ttctcagagg cttggcggga aaaagaacgg agggagggat cgcgctgagt 2461 ataaaagccg gttttcgggg ctttatctaa ctcgctgtag taattccagc gagaggcaga 2521 gggagcgagc gggcggccgg ctagggtgga agagccgggc gagcagagct gcgctgcggg 2581 cgtcctggga agggagatcc ggagcgaata gggggcttcg cctctggccc agccctcccg 2641 ctgatccccc agccagcggt ccgcaaccct tgccgcatcc acgaaacttt gcccatagca 2701 gcgggcgggc actttgcact ggaacttaca acacccgagc aaggacgcga ctctcccgac 2761 gcggggaggc tattctgccc atttggggac acttccccgc cgctgccagg acccgcttct 2821 ctgaaaggct ctccttgcag ctgcttagac gctggatttt tttcgggtag tggaaaacca 2881 ggtaagcacc gaagtccact tgccttttaa tttatttttt tatcacttta atgctgagat 2941 gagtcgaatg cctaaatagg gtgtcttttc tcccattcct gcgctattga cacttttctc 3001 agagtagtta tggtaactgg ggctggggtg gggggtaatc cagaactgga tcggggtaaa 3061 gtgacttgtc aagatgggag aggagaaggc agagggaaaa cgggaatggt ttttaagact 3121 accctttcga gatttctgcc ttatgaatat attcacgctg actcccggcc ggtcggacat 3181 tcctgcttta ttgtgttaat tgctctctgg gttttggggg gctgggggtt gctttgcggt 3241 gggcagaaag ccccttgcat cctgagctcc ttggagtagg gaccgcatat cgcctgtgtg 3301 agccagatcg ctccgcagcc gctgacttgt ccccgtctcc gggagggcat ttaaatttcg 3361 gctcaccgca tttctgacag ccggagacgg acactgcggc gcgtcccgcc cgcctgtccc 3421 cgcggcgatt ccaacccgcc ctgatccttt taagaagttg gcatttggct ttttaaaaag 3481 caataataca atttaaaacc tgggtctcta gaggtgttag gacgtggtgt tgggtaggcg 3541 caggcagggg aaaagggagg cgaggatgtg tccgattctc ctggaatcgt tgacttggaa 3601 aaaccagggc gaatctccgc acccagccct gactcccctg ccgcggccgc cctcgggtgt 3661 cctcgcgccc gagatgcgga ggaactgcga ggagcggggc tctgggcggt tccagaacag 3721 ctgctaccct tggtggggtg gctccggggg aggtatcgca gcggggtctc tggcgcagtt 3781 gcatctccgt attgagtgcg aagggaggtg cccctattat tatttgacac cccccttgta 3841 tttatggagg ggtgttaaag cccgcggctg agctcgccac tccagccggc gagagaaaga 3901 agaaaagctg gcaaaaggag tgttggacgg gggcggtact gggggtgggg acgggggcgg 3961 tggagaggga aggttgggag gggctgcggt gccggcgggg gtaggagagc ggctagggcg 4021 cgagtgggaa cagccgcagc ggaggggccc cggcgcggag cggggttcac gcagccgcta 4081 gcgcccaggc gcctctcgcc ttctccttca ggtggcgcaa aactttgtgc cttggatttt 4141 ggcaaattgt tttcctcacc gccacctccc gcggcttctt aagggcgcca gggccgattt 4201 cgattcctct gccgctgcgg ggccgactcc cgggctttgc gctccgggct cccgggggag 4261 cgggggctcg gcgggcacca agccgctggt tcactaagtg cgtctccgag atagcagggg 4321 actgtccaaa gggggtgaaa gggtgctccc tttattcccc caccaagacc acccagccgc 4381 tttaggggat agctctgcaa ggggagaggt tcgggactgt ggcgcgcact gcgcgctgcg 4441 ccaggtttcc gcaccaagac ccctttaact caagactgcc tcccgctttg tgtgccccgc 4501 tccagcagcc tcccgcgacg atgcccctca acgttagctt caccaacagg aactatgacc 4561 tcgactacga ctcggtgcag ccgtatttct actgcgacga ggaggagaac ttctaccagc 4621 agcagcagca gagcgagctg cagcccccgg cgcccagcga ggatatctgg aagaaattcg 4681 agctgctgcc caccccgccc ctgtccccta gccgccgctc cgggctctgc tcgccctcct 4741 acgttgcggt cacacccttc tcccttcggg gagacaacga cggcggtggc gggagcttct 4801 ccacggccga ccagctggag atggtgaccg agctgctggg aggagacatg gtgaaccaga 4861 gtttcatctg cgacccggac gacgagacct tcatcaaaaa catcatcatc caggactgta 4921 tgtggagcgg cttctcggcc gccgccaagc tcgtctcaga gaagctggcc tcctaccagg 4981 ctgcgcgcaa agacagcggc agcccgaacc ccgcccgcgg ccacagcgtc tgctccacct 5041 ccagcttgta cctgcaggat ctgagcgccg ccgcctcaga gtgcatcgac ccctcggtgg 5101 tcttccccta ccctctcaac gacagcagct cgcccaagtc ctgcgcctcg caagactcca 5161 gcgccttctc tccgtcctcg gattctctgc tctcctcgac ggagtcctcc ccgcagggca 5221 gccccgagcc cctggtgctc catgaggaga caccgcccac caccagcagc gactctggta 5281 agcgaagccc gcccaggcct gtcaaaagtg ggcggctgga tacctttccc attttcattg 5341 gcagcttatt taacgggcca ctcttattag gaaggagaga tagcagatct ggagagattt 5401 gggagctcat cacctctgaa accttgggct ttagcgtttc ctcccatccc ttccccttag 5461 actgcccatg tttgcagccc ccctccccgt ttgtctccca cccctcagga atttcattta 5521 ggtttttaaa ccttctggct tatcttacaa ctcaatccac ttcttcttac ctcccgttaa 5581 cattttaatt gccctggggc ggggtggcag ggagtgtatg aatgaggata agagaggatt 5641 gatctctgag agtgaatgaa ttgcttccct cttaacttcc gagaagtggt gggatttaat 5701 gaactatcta caaaaatgag gggctgtgtt tagaggctag gcagggcctg cctgagtgcg 5761 ggagccagtg aactgcctca agagtgggtg ggctgaggag ctgggatctt ctcagcctat 5821 tttgaacact gaaaagcaaa tccttgccaa agttggactt ttttttttct tttattcctt 5881 cccccgccct cttggacttt tggcaaaact gcaatttttt tttttttatt tttcatttcc 5941 agtaaaatag ggagttgcta aagtcatacc aagcaatttg cagctatcat ttgcaacacc 6001 tgaagtgttc ttggtaaagt ccctcaaaaa taggaggtgc ttgggaatgt gctttgcttt 6061 gggtgtgtcc aaagcctcat taagtcttag gtaagaattg gcatcaatgt cctatcctgg 6121 gaagttgcac ttttcttgtc catgccataa cccagctgtc tttcccttta tgagactctt 6181 accttcatgg tgagaggagt aagggtggct ggctagattg gttctttttt tttttttttc 6241 cttttttaag acggagtctc actctgtcac taggctggag tgcagtggcg caatcaacct 6301 ccaaccccct ggttcaagag attctcctgc ctcagcctcc caagtagctg ggactacagg 6361 tgcacaccac catgccaggc taatttttgt aattttagta gagatggggt ttcatcgtgt 6421 tggccaggat ggtctctcct gacctcacga tccgcccacc tcggcctccc aaagtgctgg 6481 gattacaggt gtgagccagg gcaccaggct tagatgtggc tctttgggga gataattttg 6541 tccagagacc tttctaacgt attcatgcct tgtatttgta cagcattaat ctggtaattg 6601 attattttaa tgtaaccttg ctaaaggagt gatttctatt tcctttctta aagaggagga 6661 acaagaagat gaggaagaaa tcgatgttgt ttctgtggaa aagaggcagg ctcctggcaa 6721 aaggtcagag tctggatcac cttctgctgg aggccacagc aaacctcctc acagcccact 6781 ggtcctcaag aggtgccacg tctccacaca tcagcacaac tacgcagcgc ctccctccac 6841 tcggaaggac tatcctgctg ccaagagggt caagttggac agtgtcagag tcctgagaca 6901 gatcagcaac aaccgaaaat gcaccagccc caggtcctcg gacaccgagg agaatgtcaa 6961 gaggcgaaca cacaacgtct tggagcgcca gaggaggaac gagctaaaac ggagcttttt 7021 tgccctgcgt gaccagatcc cggagttgga aaacaatgaa aaggccccca aggtagttat 7081 ccttaaaaaa gccacagcat acatcctgtc cgtccaagca gaggagcaaa agctcatttc 7141 tgaagaggac ttgttgcgga aacgacgaga acagttgaaa cacaaacttg aacagctacg 7201 gaactcttgt gcgtaaggaa aagtaaggaa aacgattcct tctaacagaa atgtcctgag 7261 caatcaccta tgaacttgtt tcaaatgcat gatcaaatgc aacctcacaa ccttggctga 7321 gtcttgagac tgaaagattt agccataatg taaactgcct caaattggac tttgggcata 7381 aaagaacttt tttatgctta ccatcttttt tttttcttta acagatttgt atttaagaat 7441 tgtttttaaa aaattttaag atttacacaa tgtttctctg taaatattgc cattaaatgt 7501 aaataacttt aataaaacgt ttatagcagt tacacagaat ttcaatccta gtatatagta 7561 cctagtatta taggtactat aaaccctaat tttttttatt taagtacatt ttgcttttta 7621 aagttgattt ttttctattg tttttagaaa aaataaaata actggcaaat atatcattga 7681 gccaaatctt aagttgtgaa tgttttgttt cgtttcttcc ccctcccaac caccaccatc 7741 cctgtttgtt ttcatcaatt gccccttcag agggcggtct taagaaaggc aagagttttc 7801 ctctgttgaa atgggtctgg gggccttaag gtctttaagt tcttggaggt tctaagatgc 7861 ttcctggaga ctatgataac agccagagtt gacagttaga aggaatggca gaaggcaggt 7921 gagaaggtga gaggtaggca aaggagatac aagaggtcaa aggtagcagt taagtacaca 7981 aagaggcata aggactgggg agttgggagg aaggtgagga agaaactcct gttactttag 8041 ttaaccagtg ccagtcccct gctcactcca aacccaggaa tt //