LOCUS       TNFRII       2394 bp ss-mRNA            PRI       18-OCT-1990
DEFINITION  Human tumor necrosis factor receptor II (TNFrII) mRNA, complete
            cds.
ACCESSION   M55994 M38549
KEYWORDS    tumor necrosis factor receptor; tumor necrosis factor receptor II.
SOURCE      Human histiocytic lymphoma cell line U937, cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
            Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 2394)
  AUTHORS   Kohno,T., Brewer,M.T., Baker,S.L., Schwartz,P.E., King,M.W.,
            Hale,K.K., Squires,C.H., Thompson,R.C. and Vannice,J.L.
  TITLE     A second tumor necrosis factor receptor gene product can shed a
            naturally occurring tumor necrosis factor inhibitor
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87, 8331-8335 (1990)
  STANDARD  full staff_review
FEATURES             Location/Qualifiers
     sig_peptide     93..158
                     /product="tumor necrosis factor receptor"
                     /gene="TNFrII"
                     /note="putative"
                     /codon_start=1
     CDS             93..1478
                     /product="tumor necrosis factor receptor"
                     /gene="TNFrII"
                     /evidence=EXPERIMENTAL
                     /codon_start=1
                     /translation="MAPVAVWAALAVGLELWAAAHALPAQVAFTPYAPEPGSTCRLRE
                     YYDQTAQMCCSKCSPGQHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSRCSS
                     DQVETQACTREQNRICTCRPGWYCALSKQEGCRLCAPLRKCRPGFGVARPGTETSDVV
                     CKPCAPGTFSNTTSSTDICRPHQICNVVAIPGNASRDAVCTSTSPTRSMAPGAVHLPQ
                     PVSTRSQHTQPTPEPSTAPSTSFLLPMGPSPPAEGSTGDFALPVGLIVGVTALGLLII
                     GVVNCVIMTQVKKKPLCLQREAKVPHLPADKARGTQGPEQQHLLITAPSSSSSSLESS
                     ASALDRRAPTRNQPQAPGVEASGAGEARASTGSSDSSPGGHGTQVNVTCIVNVCSSSD
                     HSSQCSSQASSTMGDTDSSPSESPKDEQVPFSKEECAFRSQLETPETLLGSTEEKPLP
                     LGVPDAGMKPS"
     mat_peptide     159..1475
                     /product="tumor necrosis factor receptor"
                     /gene="TNFrII"
                     /note="putative"
                     /codon_start=1
     source          1..2394
                     /organism="Homo sapiens"
                     /cell_line="U937"
                     /cell_type="histiocytic lymphoma"
                     /sequenced_mol="cDNA to mRNA"
BASE COUNT      484 a    743 c    739 g    428 t
ORIGIN
        1 gaattcggcg cagcggagcc tggagagaag gcgctgggct gcgagggcgc gagggcgcga
       61 gggcaggggg caaccggacc ccgcccgcac ccatggcgcc cgtcgccgtc tgggccgcgc
      121 tggccgtcgg actggagctc tgggctgcgg cgcacgcctt gcccgcccag gtggcattta
      181 caccctacgc cccggagccc gggagcacat gccggctcag agaatactat gaccagacag
      241 ctcagatgtg ctgcagcaag tgctcgccgg gccaacatgc aaaagtcttc tgtaccaaga
      301 cctcggacac cgtgtgtgac tcctgtgagg acagcacata cacccagctc tggaactggg
      361 ttcccgagtg cttgagctgt ggctcccgct gtagctctga ccaggtggaa actcaagcct
      421 gcactcggga acagaaccgc atctgcacct gcaggcccgg ctggtactgc gcgctgagca
      481 agcaggaggg gtgccggctg tgcgcgccgc tgcgcaagtg ccgcccgggc ttcggcgtgg
      541 ccagaccagg aactgaaaca tcagacgtgg tgtgcaagcc ctgtgccccg gggacgttct
      601 ccaacacgac ttcatccacg gatatttgca ggccccacca gatctgtaac gtggtggcca
      661 tccctgggaa tgcaagcagg gatgcagtct gcacgtccac gtcccccacc cggagtatgg
      721 ccccaggggc agtacactta ccccagccag tgtccacacg atcccaacac acgcagccaa
      781 ctccagaacc cagcactgct ccaagcacct ccttcctgct cccaatgggc cccagccccc
      841 cagctgaagg gagcactggc gacttcgctc ttccagttgg actgattgtg ggtgtgacag
      901 ccttgggtct actaataata ggagtggtga actgtgtcat catgacccag gtgaaaaaga
      961 agcccttgtg cctgcagaga gaagccaagg tgcctcactt gcctgccgat aaggcccggg
     1021 gtacacaggg ccccgagcag cagcacctgc tgatcacagc gccgagctcc agcagcagct
     1081 ccctggagag ctcggccagt gcgttggaca gaagggcgcc cactcggaac cagccacagg
     1141 caccaggcgt ggaggccagt ggggccgggg aggcccgggc cagcaccggg agctcagatt
     1201 cttcccctgg tggccatggg acccaggtca atgtcacctg catcgtgaac gtctgtagca
     1261 gctctgacca cagctcacag tgctcctccc aagccagctc cacaatggga gacacagatt
     1321 ccagcccctc ggagtccccg aaggacgagc aggtcccctt ctccaaggag gaatgtgcct
     1381 ttcggtcaca gctggagacg ccagagaccc tgctggggag caccgaagag aagcccctgc
     1441 cccttggagt gcctgatgct gggatgaagc ccagttaacc aggccggtgt gggctgtgtc
     1501 gtagccaagg tgggctgagc cctggcagga tgaccctgcg aaggggccct ggtccttcca
     1561 ggcccccacc actaggactc tgaggctctt tctgggccaa gttcctctag tgccctccac
     1621 agccgcagcc tccctctgac ctgcaggcca agagcagagg cagcgggttg tggaaagcct
     1681 ctgctgccat ggtgtgtccc tctcggaagg ctggctgggc atggacgttc ggggcatgct
     1741 ggggcaagtc cctgactctc tgtgacctgc cccgcccagc tgcacctgcc agcctggctt
     1801 ctggagccct tgggtttttt gtttgtttgt ttgtttgttt gtttgtttct ccccctgggc
     1861 tctgccccag ctctggcttc cagaaaaccc cagcatcctt ttctgcagag gggctttctg
     1921 gagaggaggg atgctgcctg agtcacccat gaagacagga cagtgcttca gcctgaggct
     1981 gagactgcgg gatggtcctg gggctctgtg cagggaggag gtggcagccc tgtagggaac
     2041 ggggtccttc aagttagctc aggaggcttg gaaagcatca cctcaggcca ggtgcagtcc
     2101 ctcacgccta tgatcccagc actttgggag gctgaggcgg gtggatcacc tgaggttagg
     2161 agttcgagac cagcctggcc aacatggtaa aaccccatct ctactaaaaa tacagaaatt
     2221 agccgggcgt ggtggcgggc acctatagtc ccagctactc agaagcctga ggctgggaaa
     2281 tcgtttgaac ccgggaagcg gaggttgcag ggagccgaga tcacgccact gcactccagc
     2341 ctgggcgaca gagcgagagt ctgtctcaaa agaaaaaaaa aaaaaaccga attc
//