LOCUS PDGFRSK5 5570 bp ss-mRNA PRI 28-SEP-1992 DEFINITION Human platelet-derived growth factor (PDGF) receptor mRNA, complete cds. ACCESSION J03278 KEYWORDS cell surface glycoprotein; glycoprotein; kinase; tyrosine kinase. SOURCE Human skin fibroblast cell (SK5), cDNA to mRNA, clone phPDGFR. ORGANISM Homo sapiens Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 5570) AUTHORS Gronwald,R.G.K., Grant,F.J., Haldeman,B.A., Hart,C.E., O'Hara,P.J., Hagen,F.S., Ross,R., Bowen-Pope,D.F. and Murray,M.J. TITLE Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class JOURNAL Proc. Natl. Acad. Sci. U.S.A. 85, 3435-3439 (1988) STANDARD full staff_review COMMENT Draft entry and computer-readable sequence [1] kindly submitted by R.G.K.Gronwald, 06-APR-1988. FEATURES Location/Qualifiers sig_peptide 357..452 /gene="PDGFRB" /map="5q33-q35" /codon_start=1 CDS 357..3677 /product="platelet-derived growth factor receptor" /gene="PDGFRB" /map="5q33-q35" /codon_start=1 /translation="MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVL NVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTH NDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTL HEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSV NAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSIL HIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSR TLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAG HYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSA CRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRC TLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRW KVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSH SQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITE YCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGY MDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVL SYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSN YISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFY NAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQ VDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKP EVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQ LPDSGCPAPRAEAEDSFL" mat_peptide 453..3674 /product="platelet-derived growth factor receptor" /gene="PDGFRB" /map="5q33-q35" /codon_start=1 source 1..5570 /organism="Homo sapiens" /cell_line="SK5" /cell_type="fibroblast" /sequenced_mol="cDNA to mRNA" /tissue_type="skin" BASE COUNT 1195 a 1676 c 1530 g 1169 t ORIGIN Chromosome 5q31-q32. 1 ggcccctcag ccctgctgcc cagcacgagc ctgtgctcgc cctgcccaac gcagacagcc 61 agacccaggg cggcccctct ggcggctctg ctcctcccga aggatgcttg gggagtgagg 121 cgaagctggg cgctcctctc ccctacagca gcccccttcc tccatccctc tgttctcctg 181 agccttcagg agcctgcacc agtcctgcct gtccttctac tcagctgtta cccactctgg 241 gaccagcagt ctttctgata actgggagag ggcagtaagg aggacttcct ggagggggtg 301 actgtccaga gcctggaact gtgcccacac cagaagccat cagcagcaag gacaccatgc 361 ggcttccggg tgcgatgcca gctctggccc tcaaaggcga gctgctgttg ctgtctctcc 421 tgttacttct ggaaccacag atctctcagg gcctggtcgt cacacccccg gggccagagc 481 ttgtcctcaa tgtctccagc accttcgttc tgacctgctc gggttcagct ccggtggtgt 541 gggaacggat gtcccaggag cccccacagg aaatggccaa ggcccaggat ggcaccttct 601 ccagcgtgct cacactgacc aacctcactg ggctagacac gggagaatac ttttgcaccc 661 acaatgactc ccgtggactg gagaccgatg agcggaaacg gctctacatc tttgtgccag 721 atcccaccgt gggcttcctc cctaatgatg ccgaggaact attcatcttt ctcacggaaa 781 taactgagat caccattcca tgccgagtaa cagacccaca gctggtggtg acactgcacg 841 agaagaaagg ggacgttgca ctgcctgtcc cctatgatca ccaacgtggc ttttctggta 901 tctttgagga cagaagctac atctgcaaaa ccaccattgg ggacagggag gtggattctg 961 atgcctacta tgtctacaga ctccaggtgt catccatcaa cgtctctgtg aacgcagtgc 1021 agactgtggt ccgccagggt gagaacatca ccctcatgtg cattgtgatc gggaatgagg 1081 tggtcaactt cgagtggaca tacccccgca aagaaagtgg gcggctggtg gagccggtga 1141 ctgacttcct cttggatatg ccttaccaca tccgctccat cctgcacatc cccagtgccg 1201 agttagaaga ctcggggacc tacacctgca atgtgacgga gagtgtgaat gaccatcagg 1261 atgaaaaggc catcaacatc accgtggttg agagcggcta cgtgcggctc ctgggagagg 1321 tgggcacact acaatttgct gagctgcatc ggagccggac actgcaggta gtgttcgagg 1381 cctacccacc gcccactgtc ctgtggttca aagacaaccg caccctgggc gactccagcg 1441 ctggcgaaat cgccctgtcc acgcgcaacg tgtcggagac ccggtatgtg tcagagctga 1501 cactggttcg cgtgaaggtg gcagaggctg gccactacac catgcgggcc ttccatgagg 1561 atgctgaggt ccagctctcc ttccagctac agatcaatgt ccctgtccga gtgctggagc 1621 taagtgagag ccaccctgac agtggggaac agacagtccg ctgtcgtggc cggggcatgc 1681 cccagccgaa catcatctgg tctgcctgca gagacctcaa aaggtgtcca cgtgagctgc 1741 cgcccacgct gctggggaac agttccgaag aggagagcca gctggagact aacgtgacgt 1801 actgggagga ggagcaggag tttgaggtgg tgagcacact gcgtctgcag cacgtggatc 1861 ggccactgtc ggtgcgctgc acgctgcgca acgctgtggg ccaggacacg caggaggtca 1921 tcgtggtgcc acactccttg ccctttaagg tggtggtgat ctcagccatc ctggccctgg 1981 tggtgctcac catcatctcc cttatcatcc tcatcatgct ttggcagaag aagccacgtt 2041 acgagatccg atggaaggtg attgagtctg tgagctctga cggccatgag tacatctacg 2101 tggaccccat gcagctgccc tatgactcca cgtgggagct gccgcgggac cagcttgtgc 2161 tgggacgcac cctcggctct ggggcctttg ggcaggtggt ggaggccacg gctcatggcc 2221 tgagccattc tcaggccacg atgaaagtgg ccgtcaagat gcttaaatcc acagcccgca 2281 gcagtgagaa gcaagccctt atgtcggagc tgaagatcat gagtcacctt gggccccacc 2341 tgaacgtggt caacctgttg ggggcctgca ccaaaggagg acccatctat atcatcactg 2401 agtactgccg ctacggagac ctggtggact acctgcaccg caacaaacac accttcctgc 2461 agcaccactc cgacaagcgc cgcccgccca gcgcggagct ctacagcaat gctctgcccg 2521 ttgggctccc cctgcccagc catgtgtcct tgaccgggga gagcgacggt ggctacatgg 2581 acatgagcaa ggacgagtcg gtggactatg tgcccatgct ggacatgaaa ggagacgtca 2641 aatatgcaga catcgagtcc tccaactaca tggcccctta cgataactac gttccctctg 2701 cccctgagag gacctgccga gcaactttga tcaacgagtc tccagtgcta agctacatgg 2761 acctcgtggg cttcagctac caggtggcca atggcatgga gtttctggcc tccaagaact 2821 gcgtccacag agacctggcg gctaggaacg tgctcatctg tgaaggcaag ctggtcaaga 2881 tctgtgactt tggcctggct cgagacatca tgcgggactc gaattacatc tccaaaggca 2941 gcaccttttt gcctttaaag tggatggctc cggagagcat cttcaacagc ctctacacca 3001 ccctgagcga cgtgtggtcc ttcgggatcc tgctctggga gatcttcacc ttgggtggca 3061 ccccttaccc agagctgccc atgaacgagc agttctacaa tgccatcaaa cggggttacc 3121 gcatggccca gcctgcccat gcctccgacg agatctatga gatcatgcag aagtgctggg 3181 aagagaagtt tgagattcgg ccccccttct cccagctggt gctgcttctc gagagactgt 3241 tgggcgaagg ttacaaaaag aagtaccagc aggtggatga ggagtttctg aggagtgacc 3301 acccagccat ccttcggtcc caggcccgct tgcctgggtt ccatggcctc cgatctcccc 3361 tggacaccag ctccgtcctc tatactgccg tgcagcccaa tgagggtgac aacgactata 3421 tcatccccct gcctgacccc aaacccgagg ttgctgacga gggcccactg gagggttccc 3481 ccagcctagc cagctccacc ctgaatgaag tcaacacctc ctcaaccatc tcctgtgaca 3541 gccccctgga gccccaggac gaaccagagc cagagcccca gcttgagctc caggtggagc 3601 cggagccaga gctggaacag ttgccggatt cggggtgccc tgcgcctcgg gcggaagcag 3661 aggatagctt cctgtagggg gctggcccct accctgccct gcctgaagct ccccccctgc 3721 cagcacccag catctcctgg cctggcctga ccgggcttcc tgtcagccag gctgccctta 3781 tcagctgtcc ccttctggaa gctttctgct cctgacgtgt tgtgccccaa accctggggc 3841 tggcttagga ggcaagaaaa ctgcaggggc cgtgaccagc cctctgcctc cagggaggcc 3901 aactgactct gagccagggt tcccccaggg aactcagttt tcccatatgt aagatgggaa 3961 agttaggctt gatgacccag aatctaggat tctctccctg gctgacaggt ggggagaccg 4021 aatccctccc tgggaagatt cttggagtta ctgaggtggt aaattaactt ttttctgttc 4081 agccagctac ccctcaagga atcatagctc tctcctcgca ctttttatcc acccaggagc 4141 tagggaagag accctagcct ccctggctgc tggctgagct agggcctagc cttgagcagt 4201 gttgcctcat ccagaagaaa gccagtctcc tccctatgat gccagtccct gcgttccctg 4261 gcccgagctg gtctggggcc attaggcagc ctaattaatg ctggaggctg agccaagtac 4321 aggacacccc cagcctgcag cccttgccca gggcacttgg agcacacgca gccatagcaa 4381 gtgcctgtgt ccctgtcctt caggcccatc agtcctgggg ctttttcttt atcaccctca 4441 gtcttaatcc atccaccaga gtctagaagg ccagacgggc cccgcatctg tgatgagaat 4501 gtaaatgtgc cagtgtggag tggccacgtg tgtgtgccag tatatggccc tggctctgca 4561 ttggacctgc tatgaggctt tggaggaatc cctcaccctc tctgggcctc agtttcccct 4621 tcaaaaaatg aataagtcgg acttattaac tctgagtgcc ttgccagcac taacattcta 4681 gagtattcca ggtggttgca catttgtcca gatgaagcaa ggccatatac cctaaacttc 4741 catcctgggg gtcagctggg ctcctgggag attccagatc acacatcaca ctctggggac 4801 tcaggaacca tgccccttcc ccaggccccc agcaagtctc aagaacacag ctgcacaggc 4861 cttgacttag agtgacagcc ggtgtcctgg aaagccccaa gcagctgccc cagggacatg 4921 ggaagaccac gggacctctt tcactaccca cgatgacctc cgggggtatc ctgggcaaaa 4981 gggacaaaga gggcaaatga gatcacctcc tgcagcccac cactccagca cctgtgccga 5041 ggtctgcgtc gaagacagaa tggacagtga ggacagttat gtcttgtaaa agacaagaag 5101 cttcagatgg taccccaaga aggatgtgag aggtggccgc ttggagtttg cccctcaccc 5161 accagctgcc ccatccctga ggcagcgctc catgggggta tggttttgtc actgcccaga 5221 cctagcagtg acatctcatt gtccccagcc cagtgggcat tggaggtgcc aggggagtca 5281 gggttgtagc caagacgccc ccgcacgggg agggttggga agggggtgca ggaagctcaa 5341 cccctctggg caccaaccct gcattgcagg ttggcacctt acttccctgg gatccccaga 5401 gttggtccaa ggagggagag tgggttctca atacggtacc aaagatataa tcacctaggt 5461 ttacaaatat ttttaggact cacgttaact cacatttata cagcagaaat gctattttgt 5521 atgctgttaa gtttttctat ctgtgtactt ttttttaagg gaaagatttt //