LOCUS PDGFAR 6375 bp ss-mRNA PRI 28-SEP-1992 DEFINITION Human platelet-derived growth factor A type receptor mRNA, complete cds. ACCESSION M22734 KEYWORDS growth factor receptor; platelet-derived growth factor A type receptor; transmembrane glycoprotein; tyrosine kinase. SOURCE Human foreskin fibroblast AG 1518 cell line, cDNA to mRNA, clone phPDGFRA15. ORGANISM Homo sapiens Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 6375) AUTHORS Claesson-Welsh,L., Eriksson,A., Westermark,B. and Heldin,C.-H. TITLE cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor JOURNAL Proc. Natl. Acad. Sci. U.S.A. 86, 4917-4921 (1989) STANDARD full staff_review COMMENT Draft entry and computer-readable sequence for [1] kindly submitted by L.Claesson-Welsh, 09-MAY-1989. FEATURES Location/Qualifiers mRNA 1..>6375 /note="PDGF type A receptor mRNA" sig_peptide 129..197 /gene="PDGFA" /map="7pter-p21" /codon_start=1 CDS 129..3398 /product="platelet-derived growth factor A receptor" /gene="PDGFA" /map="7pter-p21" /codon_start=1 /translation="MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSS FSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYY NHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVT LHNSEGVVPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEM EALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLT VPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKH FVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHY TIVAQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMIC KDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLG AENRELKLVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESIS PDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKV AVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDL VNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTT QYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSF TYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTF LPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYR MAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKS DHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPE EEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDSSDLVEDSF L" mat_peptide 198..3395 /product="platelet-derived growth factor A receptor" /gene="PDGFA" /map="7pter-p21" /codon_start=1 source 1..6375 /organism="Homo sapiens" /cell_line="AG 1518" /cell_type="fibroblast" /sequenced_mol="cDNA to mRNA" /tissue_type="foreskin" BASE COUNT 1902 a 1297 c 1443 g 1731 t 2 others ORIGIN Unreported. 1 ttggagctac agggagagaa acagaggagg agactgcaag agatcattgg aggccgtggg 61 cacgctcttt actccatgtg tgggacattc attgcggaat aacatcggag gagaagtttc 121 ccagagctat ggggacttcc catccggcgt tcctggtctt aggctgtctt ctcacagggc 181 tgagcctaat cctctgccag ctttcattac cctctatcct tccaaatgaa aatgaaaagg 241 ttgtgcagct gaattcatcc ttttctctga gatgctttgg ggagagtgaa gtgagctggc 301 agtaccccat gtctgaagaa gagagctccg atgtggaaat cagaaatgaa gaaaacaaca 361 gcggcctttt tgtgacggtc ttggaagtga gcagtgcctc ggcggcccac acagggttgt 421 acacttgcta ttacaaccac actcagacag aagagaatga gcttgaaggc aggcacattt 481 acatctatgt gccagaccca gatgtagcct ttgtacctct aggaatgacg gattatttag 541 tcatcgtgga ggatgatgat tctgccatta taccttgtcg cacaactgat cccgagactc 601 ctgtaacctt acacaacagt gagggggtgg tacctgcctc ctacgacagc agacagggct 661 ttaatgggac cttcactgta gggccctata tctgtgaggc caccgtcaaa ggaaagaagt 721 tccagaccat cccatttaat gtttatgctt taaaagcaac atcagagctg gatctagaaa 781 tggaagctct taaaaccgtg tataagtcag gggaaacgat tgtggtcacc tgtgctgttt 841 ttaacaatga ggtggttgac cttcaatgga cttaccctgg agaagtgaaa ggcaaaggca 901 tcacaatgct ggaagaaatc aaagtcccat ccatcaaatt ggtgtacact ttgacggtcc 961 ccgaggccac ggtgaaagac agtggagatt acgaatgtgc tgcccgccag gctaccaggg 1021 aggtcaaaga aatgaagaaa gtcactattt ctgtccatga gaaaggtttc attgaaatca 1081 aacccacctt cagccagttg gaagctgtca acctgcatga agtcaaacat tttgttgtag 1141 aggtgcgggc ctacccacct cccaggatat cctggctgaa aaacaatctg actctgattg 1201 aaaatctcac tgagatcacc actgatgtgg aaaagattca ggaaataagg tatcgaagca 1261 aattaaagct gatccgtgct aaggaagaag acagtggcca ttatactatt gtagctcaaa 1321 atgaagatgc tgtgaagagc tatacttttg aactgttaac tcaagttcct tcatccattc 1381 tggacttggt cgatgatcac catggctcaa ctgggggaca gacggtgagg tgcacagctg 1441 aaggcacgcc gcttcctgat attgagtgga tgatatgcaa agatattaag aaatgtaata 1501 atgaaacttc ctggactatt ttggccaaca atgtctcaaa catcatcacg gagatccact 1561 cccgagacag gagtaccgtg gagggccgtg tgactttcgc caaagtggag gagaccatcg 1621 ccgtgcgatg cctggctaag aatctccttg gagctgagaa ccgagagctg aagctggtgg 1681 ctcccaccct gcgttctgaa ctcacggtgg ctgctgcagt cctggtgctg ttggtgattg 1741 tgatcatctc acttattgtc ctggttgtca tttggaaaca gaaaccgagg tatgaaattc 1801 gctggagggt cattgaatca atcagcccag atggacatga atatatttat gtggacccga 1861 tgcagctgcc ttatgactca agatgggagt ttccaagaga tggactagtg cttggtcggg 1921 tcttggggtc tggagcgttt gggaaggtgg ttgaaggaac agcctatgga ttaagccggt 1981 cccaacctgt catgaaagtt gcagtgaaga tgctaaaacc cacggccaga tccagtgaaa 2041 aacaagctct catgtctgaa ctgaagataa tgactcacct ggggccacat ttgaacattg 2101 taaacttgct gggagcctgc accaagtcag gccccattta catcatcaca gagtattgct 2161 tctatggaga tttggtcaac tatttgcata agaataggga tagcttcctg agccaccacc 2221 cagagaagcc aaagaaagag ctggatatct ttggattgaa ccctgctgat gaaagcacac 2281 ggagctatgt tattttatct tttgaaaaca atggtgacta catggacatg aagcaggctg 2341 atactacaca gtatgtcccc atgctagaaa ggaaagaggt ttctaaatat tccgacatcc 2401 agagatcact ctatgatcgt ccagcctcat ataagaagaa atctatgtta gactcagaag 2461 tcaaaaacct cctttcagat gataactcag aaggccttac tttattggat ttgttgagct 2521 tcacctatca agttgcccga ggaatggagt ttttggcttc aaaaaattgt gtccaccgtg 2581 atctggctgc tcgcaacgtt ctcctggcac aaggaaaaat tgtgaagatc tgtgactttg 2641 gcctggccag agacatcatg catgattcga actatgtgtc gaaaggcagt acctttctgc 2701 ccgtgaagtg gatggctcct gagagcatct ttgacaacct ctacaccaca ctgagtgatg 2761 tctggtctta tggcattctg ctctgggaga tcttttccct tggtggcacc ccttaccccg 2821 gcatgatggt ggattctact ttctacaata agatcaagag tgggtaccgg atggccaagc 2881 ctgaccacgc taccagtgaa gtctacgaga tcatggtgaa atgctggaac agtgagccgg 2941 agaagagacc ctccttttac cacctgagtg agattgtgga gaatctgctg cctggacaat 3001 ataaaaagag ttatgaaaaa attcacctgg acttcctgaa gagtgaccat cctgctgtgg 3061 cacgcatgcg tgtggactca gacaatgcat acattggtgt cacctacaaa aacgaggaag 3121 acaagctgaa ggactgggag ggtggtctgg atgagcagag actgagcgct gacagtggct 3181 acatcattcc tctgcctgac attgaccctg tccctgagga ggaggacctg ggcaagagga 3241 acagacacag ctcgcagacc tctgaagaga gtgccattga gacgggttcc agcagttcca 3301 ccttcatcaa gagagaggac gagaccattg aagacatcga catgatggac gacatcggca 3361 tagactcttc agacctggtg gaagacagct tcctgtaact ggcggattcg aggggttcct 3421 tccacttctg gggccacctc tggatcccgt tcagaaaacc actttattgc aatgcggagg 3481 ttgagaggag gacttggttg atgtttaaag agaagttccc agccaagggc ctcggggagc 3541 ctttctaaat atgaatgaat gggatatttt gaaatgaact ttgtcagtgt tgcctcttgc 3601 aatgcctcag tagcatctca gtggtgtgtg aagtttggag atagatggat aagggaataa 3661 taggccacag aaggtgaact ttctgcttca aggacattgg tgagagtcca acagacacaa 3721 tttatactgc gacagaactt cagcattgta attatgtaaa taactctaac cacggctgtg 3781 tttagattgt attaactatc ttctttggac ttctgaagag accactcaat ccatccatgt 3841 acttccctct tgaaacctga tgtcagctgc tgttgaactt tttaaagaag tgcatgaaaa 3901 accatttttg accttaaaag gtactggtac tatagcattt tgctatcttt tttagtgtta 3961 aagagataaa gaataataat taaccaacct tgtttaatag atttgggtca tttagaagcc 4021 tgacaactca ttttcatatt gtaatctatg tttataatac tactactgtt atcagtaatg 4081 ctaaatgtgt aataatgtaa catgatttcc ctccacacaa agcacaattt aaaaacaatc 4141 cttactaagt aggtgatgag tttgacagtt tttgacattt atattaaata acatgtttct 4201 ctataaagta tggtaatagc tttagtgaat taaatttagt tgagcataga gaacaaagta 4261 aaagtagtgt tgtccaggaa gtcagaattt ttaactgtac tgaataggtt ccccaatcca 4321 tcgtattaaa aaacaattaa ctgccctctg aaataatggg attagaaaca aacaaaactc 4381 ttaagtccta aaagttctca atgtagaggc ataaacctgt gctgaacata acttctcatg 4441 tatattaccc aatggaaaat ataatgatca gcgcanaaag actggatttg cagaagttnt 4501 tttttttttt tcttcttgcc tgatgaaagc tttggcgacc ccaatatatg tattttttga 4561 atctatgaac ctgaaaaggg tcacaaagga tgcccagaca tcagcctcct tctttcaccc 4621 cttaccccaa agagaaagag tttgaaactc gagaccataa agatattctt tagtggaggc 4681 tggaagtgca ttagcctgat cctcagttct caaatgtgtg tggcagccag gtagactagt 4741 acctgggttt ccatccttga gattctgaag tatgaagtct gagggaaacc agagtctgta 4801 tttttctaaa ctccctggct gttctgatcg gccaggtttc ggaaacactg acttaggttt 4861 caggaagttg ccatgggaaa caaataattt gaactttgga acagggttct taagttggtg 4921 cgtccttcgg atgataaatt taggaaccga agtccaatca ctgtaaatta cggtagatcg 4981 atcgttaacg ctggaattaa attgaaaggt cagaatcgac tccgactctt tcgatttcaa 5041 accaaaactg tccaaaaggt tttcatttct acgatgaagg gtgacatacc ccctctaact 5101 tgaaaggggc agagggcaga agagcggagg gtgaggtatg gggcggttcc tttccgtaca 5161 tgtttttaat acgttaagtc acaaggttca gagacacatt ggtcgagtca caaaaccacc 5221 ttttttgtaa aattcaaaat gactattaaa ctccaatcta ccctcctact taacagtgta 5281 gataggtgtg acagtttgtc caaccacacc caagtaaccg taagaaacgt tatgacgaat 5341 taacgactat ggtatactta ctttgtaccc gacactaatg acgttagtga cacgatagcc 5401 gtctactacg aaaccttcta cgtcttcgtt attatttcat gaactgatgg atgaccacat 5461 tagagttacg ttcggggttg aaagaatagg ttgaaaaagt atcattcacg cttctgactc 5521 ggtctaaccg gttaattttt cttttggact gatccaagac atctcggtta atctgaactt 5581 tatgcaaaca caaagatctt agtgtcgagt tcgtaagaca aatagcgagt gagagggaac 5641 atgtcggaat aaaacaacca cgaaacgtaa aactataacg acactcggaa cgtactgtag 5701 tactccggcc tactttgaag agtcaggtcg tcaaaggtca ggattgttta cgagggtgga 5761 cttaaacata tactgacgta aacacccaca cacacacaaa agtcgtttaa ggtctaaaca 5821 aaggaaaacc ggaggacgtt tcagaggtct tcttttaaac ggttagaaag gatgaaagat 5881 aaaaatacta ctgttagttt cggccggact ctttgtgata aacactgaaa aatttgctaa 5941 tcactacagg aattttacac cagacggtta gacatgtttt accaggataa aaacacttct 6001 ccctgtattc tattttacta caatatgtag ttatacatat atacataaag atatatctga 6061 acctcttatg acggttttgt aaatactgtt cgacatagtg acggaagcaa atataaaaaa 6121 attgacacta ttaggggtgt ccgtgtaatt gacaacgtga aaacttacag gttttaaata 6181 taaaatcttt attatttttc tttctatgaa tgtacaaggg ttttgttacc acaccactta 6241 cacactcttt ttgattgaac tatcccagat ggttatgttt tacataatgc ttacggggac 6301 aagtacaaaa acaaaatttt gcacatttac ttctagaaat ataaagttat ttactatata 6361 ttaaatttcc ttaag //