LOCUS PDGFRA 6378 bp ss-mRNA PRI 14-APR-1994 DEFINITION Human platelet-derived growth factor alpha mRNA, complete cds. ACCESSION M21574 KEYWORDS platelet-derived growth factor. SOURCE Homo sapiens infant brain cDNA to mRNA. ORGANISM Homo sapiens Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 6378) AUTHORS Matsui,T., Heidaran,M., Miki,T., Popescu,N., La Rochelle,W., Kraus,M., Pierce,J. and Aaronson,S.A. TITLE Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes JOURNAL Science 243, 800-804 (1989) STANDARD full staff_review COMMENT Draft entry and computer-readable sequence for [1] kindly submitted by S.Tronick, 29-NOV-1988. FEATURES Location/Qualifiers mRNA <1..6378 /gene="PDGFA" /map="7pter-p21" sig_peptide 140..211 /gene="PDGFA" /map="7pter-p21" /codon_start=1 CDS 140..3409 /product="platelet-derived growth factor A chain" /gene="PDGFA" /map="7pter-p21" /codon_start=1 /translation="MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSS FSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYY NHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVT LHNSEGVVPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEM EALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLT VPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKH FVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHY TIVAQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMIC KDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLG AENRELKLVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESIS PDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKV AVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDL VNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTT QYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSF TYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTF LPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYR MAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKS DHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPE EEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDSSDLVEDSF L" mat_peptide 212..3406 /product="platelet-derived growth factor A chain" /gene="PDGFA" /map="7pter-p21" /codon_start=1 source 1..6378 /organism="Homo sapiens" /dev_stage="infant" /sequenced_mol="cDNA to mRNA" /tissue_type="brain" BASE COUNT 1850 a 1298 c 1445 g 1785 t ORIGIN 1 cccattactg ttggagctac agggagagaa acaggaggag actgcaagag atcatttggg 61 aaggccgtgg gcacgctctt tactccatgt gtgggacatt cattgcggaa taacatcgga 121 ggagaagttt cccagagcta tggggacttc ccatccggcg ttcctggtct taggctgtct 181 tctcacaggg ctgagcctaa tcctctgcca gctttcatta ccctctatcc ttccaaatga 241 aaatgaaaag gttgtgcagc tgaattcatc cttttctctg agatgctttg gggagagtga 301 agtgagctgg cagtacccca tgtctgaaga agagagctcc gatgtggaaa tcagaaatga 361 agaaaacaac agcggccttt ttgtgacggt cttggaagtg agcagtgcct cggcggccca 421 cacagggttg tacacttgct attacaacca cactcagaca gaagagaatg agcttgaagg 481 caggcacatt tacatctatg tgccagaccc agatgtagcc tttgtacctc taggaatgac 541 ggattattta gtcatcgtgg aggatgatga ttctgccatt ataccttgtc gcacaactga 601 tcccgagact cctgtaacct tacacaacag tgagggggtg gtacctgcct cctacgacag 661 cagacagggc tttaatggga ccttcactgt agggccctat atctgtgagg ccaccgtcaa 721 aggaaagaag ttccagacca tcccatttaa tgtttatgct ttaaaagcaa catcagagct 781 ggatctagaa atggaagctc ttaaaaccgt gtataagtca ggggaaacga ttgtggtcac 841 ctgtgctgtt tttaacaatg aggtggttga ccttcaatgg acttaccctg gagaagtgaa 901 aggcaaaggc atcacaatgc tggaagaaat caaagtccca tccatcaaat tggtgtacac 961 tttgacggtc cccgaggcca cggtgaaaga cagtggagat tacgaatgtg ctgcccgcca 1021 ggctaccagg gaggtcaaag aaatgaagaa agtcactatt tctgtccatg agaaaggttt 1081 cattgaaatc aaacccacct tcagccagtt ggaagctgtc aacctgcatg aagtcaaaca 1141 ttttgttgta gaggtgcggg cctacccacc tcccaggata tcctggctga aaaacaatct 1201 gactctgatt gaaaatctca ctgagatcac cactgatgtg gaaaagattc aggaaataag 1261 gtatcgaagc aaattaaagc tgatccgtgc taaggaagaa gacagtggcc attatactat 1321 tgtagctcaa aatgaagatg ctgtgaagag ctatactttt gaactgttaa ctcaagttcc 1381 ttcatccatt ctggacttgg tcgatgatca ccatggctca actgggggac agacggtgag 1441 gtgcacagct gaaggcacgc cgcttcctga tattgagtgg atgatatgca aagatattaa 1501 gaaatgtaat aatgaaactt cctggactat tttggccaac aatgtctcaa acatcatcac 1561 ggagatccac tcccgagaca ggagtaccgt ggagggccgt gtgactttcg ccaaagtgga 1621 ggagaccatc gccgtgcgat gcctggctaa gaatctcctt ggagctgaga accgagagct 1681 gaagctggtg gctcccaccc tgcgttctga actcacggtg gctgctgcag tcctggtgct 1741 gttggtgatt gtgatcatct cacttattgt cctggttgtc atttggaaac agaaaccgag 1801 gtatgaaatt cgctggaggg tcattgaatc aatcagcccg gatggacatg aatatattta 1861 tgtggacccg atgcagctgc cttatgactc aagatgggag tttccaagag atggactagt 1921 gcttggtcgg gtcttggggt ctggagcgtt tgggaaggtg gttgaaggaa cagcctatgg 1981 attaagccgg tcccaacctg tcatgaaagt tgcagtgaag atgctaaaac ccacggccag 2041 atccagtgaa aaacaagctc tcatgtctga actgaagata atgactcacc tggggccaca 2101 tttgaacatt gtaaacttgc tgggagcctg caccaagtca ggccccattt acatcatcac 2161 agagtattgc ttctatggag atttggtcaa ctatttgcat aagaataggg atagcttcct 2221 gagccaccac ccagagaagc caaagaaaga gctggatatc tttggattga accctgctga 2281 tgaaagcaca cggagctatg ttattttatc ttttgaaaac aatggtgact acatggacat 2341 gaagcaggct gatactacac agtatgtccc catgctagaa aggaaagagg tttctaaata 2401 ttccgacatc cagagatcac tctatgatcg tccagcctca tataagaaga aatctatgtt 2461 agactcagaa gtcaaaaacc tcctttcaga tgataactca gaaggcctta ctttattgga 2521 tttgttgagc ttcacctatc aagttgcccg aggaatggag tttttggctt caaaaaattg 2581 tgtccaccgt gatctggctg ctcgcaacgt cctcctggca caaggaaaaa ttgtgaagat 2641 ctgtgacttt ggcctggcca gagacatcat gcatgattcg aactatgtgt cgaaaggcag 2701 tacctttctg cccgtgaagt ggatggctcc tgagagcatc tttgacaacc tctacaccac 2761 actgagtgat gtctggtctt atggcattct gctctgggag atcttttccc ttggtggcac 2821 cccttacccc ggcatgatgg tggattctac tttctacaat aagatcaaga gtgggtaccg 2881 gatggccaag cctgaccacg ctaccagtga agtctacgag atcatggtga aatgctggaa 2941 cagtgagccg gagaagagac cctcctttta ccacctgagt gagattgtgg agaatctgct 3001 gcctggacaa tataaaaaga gttatgaaaa aattcacctg gacttcctga agagtgacca 3061 tcctgctgtg gcacgcatgc gtgtggactc agacaatgca tacattggtg tcacctacaa 3121 aaacgaggaa gacaagctga aggactggga gggtggtctg gatgagcaga gactgagcgc 3181 tgacagtggc tacatcattc ctctgcctga cattgaccct gtccctgagg aggaggacct 3241 gggcaagagg aacagacaca gctcgcagac ctctgaagag agtgccattg agacgggttc 3301 cagcagttcc accttcatca agagagagga cgagaccatt gaagacatcg acatgatgga 3361 cgacatcggc atagactctt cagacctggt ggaagacagc ttcctgtaac tggcggattc 3421 gaggggttcc ttccacttct ggggccacct ctggatcccg ttcagaaaac cactttattg 3481 caatgcggag gttgagagga ggacttggtt gatgtttaaa gagaagttcc cagccaaggg 3541 cctcggggag cgttctaaat atgaatgaat gggatatttt gaaatgaact ttgtcagtgt 3601 tgcctctcgc aatgcctcag tagcatctca gtggtgtgtg aagtttggag atagatggat 3661 aagggaataa taggccacag aaggtgaact ttgtgcttca aggacattgg tgagagtcca 3721 acagacacaa tttatactgc gacagaactt cagcattgta attatgtaaa taactctaac 3781 caaggctgtg tttagattgt attaactatc ttctttggac ttctgaagag accactcaat 3841 ccatccatgt acttccctct tgaaacctga tgtcagctgc tgttgaactt tttaaagaag 3901 tgcatgaaaa accatttttg aaccttaaaa ggtactggta ctatagcatt ttgctatctt 3961 ttttagtgtt aagagataaa gaataataat taaccaacct tgtttaatag atttgggtca 4021 tttagaagcc tgacaactca ttttcatatt gtaatctatg tttataatac tactactgtt 4081 atcagtaatg ctaaatgtgt aataatgtaa catgatttcc ctccagagaa agcacaattt 4141 aaaacaatcc ttactaagta ggtgatgagt ttgacagttt ttgacattta tattaaataa 4201 catgtttctc tataaagtat ggtaatagct ttagtgaatt aaatttagtt gagcatagag 4261 aacaaagtaa aagtagtgtt gtccaggaag tcagaatttt taactgtact gaataggttc 4321 cccaatccat cgtattaaaa aacaattaac tgccctctga aataatggga ttagaaacaa 4381 acaaaactct taagtcctaa aagttctcaa tgtagaggca taaacctgtg ctgaacataa 4441 cttctcatgt atattaccca atggaaaata taatgatcag caaaaagact ggatttgcag 4501 aagttttttt tttttttctt catgcctgat gaaagctttg gcaaccccaa tatatgtatt 4561 ttttgaatct atgaacctga aaagggtcag aaggatgccc agacatcagc ctccttcttt 4621 caccccttac cccaaagaga aagagtttga aactcgagac cataaagata ttctttagtg 4681 gaggctggat gtgcattagc ctggatcctc agttctcaaa tgtgtgtggc agccaggatg 4741 actagatcct gggtttccat ccttgagatt ctgaagtatg aagtctgagg gaaaccagag 4801 tctgtatttt tctaaactcc ctggctgttc tgatcggcca gttttcggaa acactgactt 4861 aggtttcagg aagttgccat gggaaacaaa taatttgaac tttggaacag ggttggaatt 4921 caaccacgca ggaagcctac tatttaaatc cttggcttca ggttagtgac atttaatgcc 4981 atctagctag caattgcgac cttaatttaa ctttccagtc ttagctgagg ctgagaaagc 5041 taaagtttgg ttttgacagg ttttccaaaa gtaaagatgc tacttcccac tgtatggggg 5101 agattgaact ttccccgtct cccgtcttct gcctcccact ccataccccg ccaaggaaag 5161 gcatgtacaa aaattatgca attcagtgtt ccaagtctct gtgtaaccag ctcagtgttt 5221 tggtggaaaa aacattttaa gttttactga taatttgagg ttagatggga ggatgaattg 5281 tcacatctat ccacactgtc aaacaggttg gtgtgggttc attggcattc tttgcaatac 5341 tgcttaattg ctgataccat atgaatgaaa catgggctgt gattactgca atcactgtgc 5401 tatcggcaga tgatgctttg gaagatgcag aagcaataat aaagtacttg actacctact 5461 ggtgtaatct caatgcaagc cccaactttc ttatccaact ttttcatagt aagtgcgaag 5521 actgagccag attggccaat taaaaacgaa aacctgacta ggttctgtag agccaattag 5581 acttgaaata cgtttgtgtt tctagaatca cagctcaagc attctgttta tcgctcactc 5641 tcccttgtac agccttattt tgttggtgct ttgcattttg atattgctgt gagccttgca 5701 tgacatcatg aggccggatg aaacttctca gtccagcagt ttccagtcct aacaaatgct 5761 cccacctgaa tttgtatatg actgcatttg tgggtgtgtg tgtgttttca gcaaattcca 5821 gatttgtttc cttttggcct cctgcaaagt ctccagaaga aaatttgcca atctttccta 5881 ctttctattt ttatgatgac aatcaaagcc ggcctgagaa acactatttg tgacttttta 5941 aacgattagt gatgtcctta aaatgtggtc tgccaatctg tacaaaatgg tcctattttt 6001 gtgaagaggg acataagata aaatgatgtt atacatcaat atgtatatat gtatttctat 6061 atagacttgg agaatactgc caaaacattt atgacaagct gtatcactgc cttcgtttat 6121 atttttttaa ctgtgataat ccccacaggc acattaactg ttgcactttt gaatgtccaa 6181 aatttatatt ttagaaataa taaaaagaaa gatacttaca tgttcccaaa acaatggtgt 6241 ggtgaatgtg tgagaaaaac taacttgata gggtctacca atacaaaatg tattacgaat 6301 gcccctgttc atgtttttgt tttaaaacgt gtaaatgaag atctttatat ttcaataaat 6361 gatatataat ttaaagtt //