LOCUS ERBB3R 4879 bp ss-mRNA PRI 15-MAR-1990 DEFINITION Human epidermal growth factor receptor (ERBB3) mRNA, complete cds. ACCESSION M29366 KEYWORDS epidermal growth factor receptor. SOURCE Human placenta, cDNA to mRNA, (library of Clontech). ORGANISM Homo sapiens Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 4879) AUTHORS Kraus,M.H., Issing,W., Miki,T., Popescu,N.C. and Aaronson,S.A. TITLE Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: Evidence for overexpression in a subset of human mammary tumors JOURNAL Proc. Natl. Acad. Sci. U.S.A. 86, 9193-9197 (1989) STANDARD full staff_review COMMENT Draft entry and computer-readable sequence for [1] kindly submitted by M.H.Kraus 31-OCT-1989. FEATURES Location/Qualifiers mRNA <1..4879 /note="ERBB3 mRNA" sig_peptide 100..156 /note="epidermal growth factor signal peptide" /codon_start=1 CDS 100..4128 /note="epidermal growth factor receptor precursor" /codon_start=1 /translation="MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAEN QYQTLYKLYERCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNL RVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDT IDWRDIVRDRDAEIVVKDNGRSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHC FGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNP HTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGT GSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVRE ITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEIS AGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGG CWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMEGTATCN GSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQGCKGP ELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLGGTFLYWRGRRIQNKRAMRRYLE RGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVC IKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDH VRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVA DLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAG LRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDP PRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEEDNLATTTLGSA LSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPRPVSLHPMP RGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPL SPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRRR RHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDYEY MNRQRDGGGPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATD SAFDNPDYWHSRLFPKANAQRT" mat_peptide 157..4825 /note="epidermal growth factor receptor" /codon_start=1 source 1..4879 /organism="Homo sapiens" BASE COUNT 1182 a 1258 c 1308 g 1131 t ORIGIN 376 bp upstream of EcoRI site. 1 accaattcgc cagcggttca ggtggctctt gcctcgatgt cctagcctag gggcccccgg 61 gccggacttg gctgggctcc cttcaccctc tgcggagtca tgagggcgaa cgacgctctg 121 caggtgctgg gcttgctttt cagcctggcc cggggctccg aggtgggcaa ctctcaggca 181 gtgtgtcctg ggactctgaa tggcctgagt gtgaccggcg atgctgagaa ccaataccag 241 acactgtaca agctctacga gaggtgtgag gtggtgatgg ggaaccttga gattgtgctc 301 acgggacaca atgccgacct ctccttcctg cagtggattc gagaagtgac aggctatgtc 361 ctcgtggcca tgaatgaatt ctctactcta ccattgccca acctccgcgt ggtgcgaggg 421 acccaggtct acgatgggaa gtttgccatc ttcgtcatgt tgaactataa caccaactcc 481 agccacgctc tgcgccagct ccgcttgact cagctcaccg agattctgtc agggggtgtt 541 tatattgaga agaacgataa gctttgtcac atggacacaa ttgactggag ggacatcgtg 601 agggaccgag atgctgagat agtggtgaag gacaatggca gaagctgtcc cccctgtcat 661 gaggtttgca aggggcgatg ctggggtcct ggatcagaag actgccagac attgaccaag 721 accatctgtg ctcctcagtg taatggtcac tgctttgggc ccaaccccaa ccagtgctgc 781 catgatgagt gtgccggggg ctgctcaggc cctcaggaca cagactgctt tgcctgccgg 841 cacttcaatg acagtggagc ctgtgtacct cgctgtccac agcctcttgt ctacaacaag 901 ctaactttcc agctggaacc caatccccac accaagtatc agtatggagg agtttgtgta 961 gccagctgtc cccataactt tgtggtggat caaacatcct gtgtcagggc ctgtcctcct 1021 gacaagatgg aagtagataa aaatgggctc aagatgtgtg agccttgtgg gggactatgt 1081 cccaaagcct gtgagggaac aggctctggg agccgcttcc agactgtgga ctcgagcaac 1141 attgatggat ttgtgaactg caccaagatc ctgggcaacc tggactttct gatcaccggc 1201 ctcaatggag acccctggca caagatccct gccctggacc cagagaagct caatgtcttc 1261 cggacagtac gggagatcac aggttacctg aacatccagt cctggccgcc ccacatgcac 1321 aacttcagtg ttttttccaa tttgacaacc attggaggca gaagcctcta caaccggggc 1381 ttctcattgt tgatcatgaa gaacttgaat gtcacatctc tgggcttccg atccctgaag 1441 gaaattagtg ctgggcgtat ctatataagt gccaataggc agctctgcta ccaccactct 1501 ttgaactgga ccaaggtgct tcgggggcct acggaagagc gactagacat caagcataat 1561 cggccgcgca gagactgcgt ggcagagggc aaagtgtgtg acccactgtg ctcctctggg 1621 ggatgctggg gcccaggccc tggtcagtgc ttgtcctgtc gaaattatag ccgaggaggt 1681 gtctgtgtga cccactgcaa ctttctgaat ggggagcctc gagaatttgc ccatgaggcc 1741 gaatgcttct cctgccaccc ggaatgccaa cccatggagg gcactgccac atgcaatggc 1801 tcgggctctg atacttgtgc tcaatgtgcc cattttcgag atgggcccca ctgtgtgagc 1861 agctgccccc atggagtcct aggtgccaag ggcccaatct acaagtaccc agatgttcag 1921 aatgaatgtc ggccctgcca tgagaactgc acccaggggt gtaaaggacc agagcttcaa 1981 gactgtttag gacaaacact ggtgctgatc ggcaaaaccc atctgacaat ggctttgaca 2041 gtgatagcag gattggtagt gattttcatg atgctgggcg gcacttttct ctactggcgt 2101 gggcgccgga ttcagaataa aagggctatg aggcgatact tggaacgggg tgagagcata 2161 gagcctctgg accccagtga gaaggctaac aaagtcttgg ccagaatctt caaagagaca 2221 gagctaagga agcttaaagt gcttggctcg ggtgtctttg gaactgtgca caaaggagtg 2281 tggatccctg agggtgaatc aatcaagatt ccagtctgca ttaaagtcat tgaggacaag 2341 agtggacggc agagttttca agctgtgaca gatcatatgc tggccattgg cagcctggac 2401 catgcccaca ttgtaaggct gctgggacta tgcccagggt catctctgca gcttgtcact 2461 caatatttgc ctctgggttc tctgctggat catgtgagac aacaccgggg ggcactgggg 2521 ccacagctgc tgctcaactg gggagtacaa attgccaagg gaatgtacta ccttgaggaa 2581 catggtatgg tgcatagaaa cctggctgcc cgaaacgtgc tactcaagtc acccagtcag 2641 gttcaggtgg cagattttgg tgtggctgac ctgctgcctc ctgatgataa gcagctgcta 2701 tacagtgagg ccaagactcc aattaagtgg atggcccttg agagtatcca ctttgggaaa 2761 tacacacacc agagtgatgt ctggagctat ggtgtgacag tttgggagtt gatgaccttc 2821 ggggcagagc cctatgcagg gctacgattg gctgaagtac cagacctgct agagaagggg 2881 gagcggttgg cacagcccca gatctgcaca attgatgtct acatggtgat ggtcaagtgt 2941 tggatgattg atgagaacat tcgcccaacc tttaaagaac tagccaatga gttcaccagg 3001 atggcccgag acccaccacg gtatctggtc ataaagagag agagtgggcc tggaatagcc 3061 cctgggccag agccccatgg tctgacaaac aagaagctag aggaagtaga gctggagcca 3121 gaactagacc tagacctaga cttggaagca gaggaggaca acctggcaac caccacactg 3181 ggctccgccc tcagcctacc agttggaaca cttaatcggc cacgtgggag ccagagcctt 3241 ttaagtccat catctggata catgcccatg aaccagggta atcttgggga gtcttgccag 3301 gagtctgcag tttctgggag cagtgaacgg tgcccccgtc cagtctctct acacccaatg 3361 ccacggggat gcctggcatc agagtcatca gaggggcatg taacaggctc tgaggctgag 3421 ctccaggaga aagtgtcaat gtgtagaagc cggagcagga gccggagccc acggccacgc 3481 ggagatagcg cctaccattc ccagcgccac agtctgctga ctcctgttac cccactctcc 3541 ccacccgggt tagaggaaga ggatgtcaac ggttatgtca tgccagatac acacctcaaa 3601 ggtactccct cctcccggga aggcaccctt tcttcagtgg gtcttagttc tgtcctgggt 3661 actgaagaag aagatgaaga tgaggagtat gaatacatga accggaggag aaggcacagt 3721 ccacctcatc cccctaggcc aagttccctt gaggagctgg gttatgagta catggatgtg 3781 gggtcagacc tcagtgcctc tctgggcagc acacagagtt gcccactcca ccctgtaccc 3841 atcatgccca ctgcaggcac aactccagat gaagactatg aatatatgaa tcggcaacga 3901 gatggaggtg gtcctggggg tgattatgca gccatggggg cctgcccagc atctgagcaa 3961 gggtatgaag agatgagagc ttttcagggg cctggacatc aggcccccca tgtccattat 4021 gcccgcctaa aaactctacg tagcttagag gctacagact ctgcctttga taaccctgat 4081 tactggcata gcaggctttt ccccaaggct aatgcccaga gaacgtaact cctgctccct 4141 gtggcactca gggagcattt aatggcagct agtgccttta gagggtaccg tcttctccct 4201 attccctctc tctcccaggt cccagcccct tttccccagt cccagacaat tccattcaat 4261 ctttggaggc ttttaaacat tttgacacaa aattcttatg gtatgtagcc agctgtgcac 4321 tttcttctct ttcccaaccc caggaaaggt tttccttatt ttgtgtgctt tcccagtccc 4381 attcctcagc ttcttcacag gcactcctgg agatatgaag gattactctc catatccctt 4441 cctctcaggc tcttgactac ttggaactag gctcttatgt gtgcctttgt ttcccatcag 4501 actgtcaaga agaggaaagg gaggaaacct agcagaggaa agtgtaattt tggtttatga 4561 ctcttaaccc cctagaaaga cagaagctta aaatctgtga agaaagaggt taggagtaga 4621 tattgattac tatcataatt cagcacttaa ctatgagcca ggcatcatac taaacttcac 4681 ctacattatc tcacttagtc ctttatcatc cttaaaacaa ttctgtgaca tacatattat 4741 ctcattttac acaaagggaa gtcgggcatg gtggctcatg cctgtaatct cagcactttg 4801 ggaggctgag gcagaaggat tacctgaggc aaggagtttg agaccagctt agccaacata 4861 gtaagacccc catctcttt //