LOCUS EGFR 5532 bp ss-mRNA PRI 13-JUN-1985 DEFINITION Human mRNA for precursor of epidermal growth factor receptor ACCESSION X00588 KEYWORDS epidermal growth factor receptor; signal peptide. SOURCE ORGANISM Homo sapiens Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 5532) AUTHORS Ullrich A., Coussens L., Hayflick J.S., Dull T.J., Gray A., Tam A.W., Lee J., Yarden Y., Libermann T.A., Schlessinger J., Downward J., Mayes E.L., Whittle N., Waterfield M.D., Seeburg P.H.; TITLE Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells JOURNAL Nature 309:418-425(1984). STANDARD full staff_review COMMENT ; FEATURES Location/Qualifiers source 1..5532 /organism="Homo sapiens" CDS 187..258 /note="put. signal peptide" CDS 259..2127 /note="EGF extracellular domain" misc_feature 568..576 /note="Asn-linked glycosylation site" misc_feature 709..717 /note="Asn-linked glycosylation site" misc_feature 772..780 /note="Asn-linked glycosylation site" misc_feature 997..1006 /note="Asn-linked glycosylation site" misc_feature 1267..1275 /note="Asn-linked glycosylation site" misc_feature 1290..1298 /note="Asn-linked glycosylation site" misc_feature 1423..1431 /note="Asn-linked glycosylation site" misc_feature 1506..1514 /note="Asn-linked glycosylation site" misc_feature 1718..1726 /note="Asn-linked glycosylation site" misc_feature 1838..1846 /note="Asn-linked glycosylation site" misc_feature 1924..3732 /note="v-erb B homology" misc_feature 1993..2001 /note="Asn-linked glycosylation site" misc_feature 2053..2061 /note="Asn-linked glycosylation site" CDS 2128..2190 /note="EGF transmembrane region" CDS 2191..3816 /note="EGF cytoplasmatic domain" misc_feature 3313..3321 /note="Asn-linked glycosylation site" misc_feature 3316..3324 /note="Asn-linked glycosylation site" misc_feature 3466..3474 /note="Asn-linked glycosylation site" misc_feature 3628..3636 /note="Asn-linked glycosylation site" misc_feature 5512..5517 /note="polyadenylation signal" polyA_site 5532..5532 /note="polyadenylation site" BASE COUNT 1472 a 1484 c 1337 g 1239 t ORIGIN 1 gccgcgctgc gccggagtcc cgagctagcc ccggcgccgc cgccgcccag accggacgac 61 aggccacctc gtcggcgtcc gcccgagtcc ccgcctcgcc gccaacgcca caaccaccgc 121 gcacggcccc ctgactccgt ccagtattga tcgggagagc cggagcgagc tcttcgggga 181 gcagcgatgc gaccctccgg gacggccggg gcagcgctcc tggcgctgct ggctgcgctc 241 tgcccggcga gtcgggctct ggaggaaaag aaagtttgcc aaggcacgag taacaagctc 301 acgcagttgg gcacttttga agatcatttt ctcagcctcc agaggatgtt caataactgt 361 gaggtggtcc ttgggaattt ggaaattacc tatgtgcaga ggaattatga tctttccttc 421 ttaaagacca tccaggaggt ggctggttat gtcctcattg ccctcaacac agtggagcga 481 attcctttgg aaaacctgca gatcatcaga ggaaatatgt actacgaaaa ttcctatgcc 541 ttagcagtct tatctaacta tgatgcaaat aaaaccggac tgaaggagct gcccatgaga 601 aatttacagg aaatcctgca tggcgccgtg cggttcagca acaaccctgc cctgtgcaac 661 gtggagagca tccagtggcg ggacatagtc agcagtgact ttctcagcaa catgtcgatg 721 gacttccaga accacctggg cagctgccaa aagtgtgatc caagctgtcc caatgggagc 781 tgctggggtg caggagagga gaactgccag aaactgacca aaatcatctg tgcccagcag 841 tgctccgggc gctgccgtgg caagtccccc agtgactgct gccacaacca gtgtgctgca 901 ggctgcacag gcccccggga gagcgactgc ctggtctgcc gcaaattccg agacgaagcc 961 acgtgcaagg acacctgccc cccactcatg ctctacaacc ccaccacgta ccagatggat 1021 gtgaaccccg agggcaaata cagctttggt gccacctgcg tgaagaagtg tccccgtaat 1081 tatgtggtga cagatcacgg ctcgtgcgtc cgagcctgtg gggccgacag ctatgagatg 1141 gaggaagacg gcgtccgcaa gtgtaagaag tgcgaagggc cttgccgcaa agtgtgtaac 1201 ggaataggta ttggtgaatt taaagactca ctctccataa atgctacgaa tattaaacac 1261 ttcaaaaact gcacctccat cagtggcgat ctccacatcc tgccggtggc atttaggggt 1321 gactccttca cacatactcc tcctctggat ccacaggaac tggatattct gaaaaccgta 1381 aaggaaatca cagggttttt gctgattcag gcttggcctg aaaacaggac ggacctccat 1441 gcctttgaga acctagaaat catacgcggc aggaccaagc aacatggtca gttttctctt 1501 gcagtcgtca gcctgaacat aacatccttg ggattacgct ccctcaagga gataagtgat 1561 ggagatgtga taatttcagg aaacaaaaat ttgtgctatg caaatacaat aaactggaaa 1621 aaactgtttg ggacctccgg tcagaaaacc aaaattataa gcaacagagg tgaaaacagc 1681 tgcaaggcca caggccaggt ctgccatgcc ttgtgctccc ccgagggctg ctggggcccg 1741 gagcccaggg actgcgtctc ttgccggaat gtcagccgag gcagggaatg cgtggacaag 1801 tgcaagcttc tggagggtga gccaagggag tttgtggaga actctgagtg catacagtgc 1861 cacccagagt gcctgcctca ggccatgaac atcacctgca caggacgggg accagacaac 1921 tgtatccagt gtgcccacta cattgacggc ccccactgcg tcaagacctg cccggcagga 1981 gtcatgggag aaaacaacac cctggtctgg aagtacgcag acgccggcca tgtgtgccac 2041 ctgtgccatc caaactgcac ctacggatgc actgggccag gtcttgaagg ctgtccaacg 2101 aatgggccta agatcccgtc catcgccact gggatggtgg gggccctcct cttgctgctg 2161 gtggtggccc tggggatcgg cctcttcatg cgaaggcgcc acatcgttcg gaagcgcacg 2221 ctgcggaggc tgctgcagga gagggagctt gtggagcctc ttacacccag tggagaagct 2281 cccaaccaag ctctcttgag gatcttgaag gaaactgaat tcaaaaagat caaagtgctg 2341 ggctccggtg cgttcggcac ggtgtataag ggactctgga tcccagaagg tgagaaagtt 2401 aaaattcccg tcgctatcaa ggaattaaga gaagcaacat ctccgaaagc caacaaggaa 2461 atcctcgatg aagcctacgt gatggccagc gtggacaacc cccacgtgtg ccgcctgctg 2521 ggcatctgcc tcacctccac cgtgcaactc atcacgcagc tcatgccctt cggctgcctc 2581 ctggactatg tccgggaaca caaagacaat attggctccc agtacctgct caactggtgt 2641 gtgcagatcg caaagggcat gaactacttg gaggaccgtc gcttggtgca ccgcgacctg 2701 gcagccagga acgtactggt gaaaacaccg cagcatgtca agatcacaga ttttgggctg 2761 gccaaactgc tgggtgcgga agagaaagaa taccatgcag aaggaggcaa agtgcctatc 2821 aagtggatgg cattggaatc aattttacac agaatctata cccaccagag tgatgtctgg 2881 agctacgggg tgaccgtttg ggagttgatg acctttggat ccaagccata tgacggaatc 2941 cctgccagcg agatctcctc catcctggag aaaggagaac gcctccctca gccacccata 3001 tgtaccatcg atgtctacat gatcatggtc aagtgctgga tgatagacgc agatagtcgc 3061 ccaaagttcc gtgagttgat catcgaattc tccaaaatgg cccgagaccc ccagcgctac 3121 cttgtcattc agggggatga aagaatgcat ttgccaagtc ctacagactc caacttctac 3181 cgtgccctga tggatgaaga agacatggac gacgtggtgg atgccgacga gtacctcatc 3241 ccacagcagg gcttcttcag cagcccctcc acgtcacgga ctcccctcct gagctctctg 3301 agtgcaacca gcaacaattc caccgtggct tgcattgata gaaatgggct gcaaagctgt 3361 cccatcaagg aagacagctt cttgcagcga tacagctcag accccacagg cgccttgact 3421 gaggacagca tagacgacac cttcctccca gtgcctgaat acataaacca gtccgttccc 3481 aaaaggcccg ctggctctgt gcagaatcct gtctatcaca atcagcctct gaaccccgcg 3541 cccagcagag acccacacta ccaggacccc cacagcactg cagtgggcaa ccccgagtat 3601 ctcaacactg tccagcccac ctgtgtcaac agcacattcg acagccctgc ccactgggcc 3661 cagaaaggca gccaccaaat tagcctggac aaccctgact accagcagga cttctttccc 3721 aaggaagcca agccaaatgg catctttaag ggctccacag ctgaaaatgc agaataccta 3781 agggtcgcgc cacaaagcag tgaatttatt ggagcatgac cacggaggat agtatgagcc 3841 ctaaaaatcc agactctttc gatacccagg accaagccac agcaggtcct ccatcccaac 3901 agccatgccc gcattagctc ttagacccac agactggttt tgcaacgttt acaccgacta 3961 gccaggaagt acttccacct cgggcacatt ttgggaagtt gcattccttt gtcttcaaac 4021 tgtgaagcat ttacagaaac gcatccagca agaatattgt ccctttgagc agaaatttat 4081 ctttcaaaga ggtatatttg aaaaaaaaaa aaaaagtata tgtgaggatt tttattgatt 4141 ggggatcttg gagtttttca ttgtcgctat tgatttttac ttcaatgggc tcttccaaca 4201 aggaagaagc ttgctggtag cacttgctac cctgagttca tccaggccca actgtgagca 4261 aggagcacaa gccacaagtc ttccagagga tgcttgattc cagtggttct gcttcaaggc 4321 ttccactgca aaacactaaa gatccaagaa ggccttcatg gccccagcag gccggatcgg 4381 tactgtatca agtcatggca ggtacagtag gataagccac tctgtccctt cctgggcaaa 4441 gaagaaacgg aggggatgaa ttcttcctta gacttacttt tgtaaaaatg tccccacggt 4501 acttactccc cactgatgga ccagtggttt ccagtcatga gcgttagact gacttgtttg 4561 tcttccattc cattgttttg aaactcagta tgccgcccct gtcttgctgt catgaaatca 4621 gcaagagagg atgacacatc aaataataac tcggattcca gcccacattg gattcatcag 4681 catttggacc aatagcccac agctgagaat gtggaatacc taaggataac accgcttttg 4741 ttctcgcaaa aacgtatctc ctaatttgag gctcagatga aatgcatcag gtcctttggg 4801 gcatagatca gaagactaca aaaatgaagc tgctctgaaa tctcctttag ccatcacccc 4861 aaccccccaa aattagtttg tgttacttat ggaagatagt tttctccttt tacttcactt 4921 caaaagcttt ttactcaaag agtatatgtt ccctccaggt cagctgcccc caaaccccct 4981 ccttacgctt tgtcacacaa aaagtgtctc tgccttgagt catctattca agcacttaca 5041 gctctggcca caacagggca ttttacaggt gcgaatgaca gtagcattat gagtagtgtg 5101 aattcaggta gtaaatatga aactagggtt tgaaattgat aatgctttca caacatttgc 5161 agatgtttta gaaggaaaaa agttccttcc taaaataatt tctctacaat tggaagattg 5221 gaagattcag ctagttagga gcccattttt tcctaatctg tgtgtgccct gtaacctgac 5281 tggttaacag cagtcctttg taaacagtgt tttaaactct cctagtcaat atccacccca 5341 tccaatttat caaggaagaa atggttcaga aaatattttc agcctacagt tatgttcagt 5401 cacacacaca tacaaaatgt tccttttgct tttaaagtaa tttttgactc ccagatcagt 5461 cagagcccct acagcattgt taagaaagta tttgattttt gtctcaatga aaataaaact 5521 atattcattt cc