ID HPV9 STANDARD; ds-DNA; VRL; 7434 bp. XX DE Human papillomavirus type 9 (HPV-9), complete genome. XX AC X74464 XX DT 04-OCT-1993 XX OS Human papillomavirus type 9 DNA. OC Human papillomavirus type 9 OC Viridae; ds-DNA nonenveloped viruses; Papovaviridae; OC Papillomavirus. XX RN [1] RP 1-7434 RA Egawa,K., Delius,H., Matsukura,T., Kawashima,M. and De Villiers,E.M.; RT "Two novel types of human papillomavirus, HPV63 and HPV65 RT comparisons of their distinct clinical and histological features RT and their DNA sequences to other HPV types"; RL Virology 194, 789-799 (1993). XX XX Submitted (27-JAN-1993) on tape to the EMBL Data Library by: H. XX Delius, Deutsches Krebsforschungszentrum, Abt ATV, Im Neuenheimer XX Feld 506, W -6900 Heidelberg, FRG. Clone = insert in BamHI site of XX pBR322. XX XX HPV-9 is most often isolated from the benign lesions of XX Epidermodysplasia Verruciformis (EV). EV is a rare genetic XX disease which is thought to be autosomal recessive, although a XX few single cases of X-linked inheritance have been reported. XX This genetic defect results in a patient who is immunotolerant. XX These patients are then infected by HPV types which are rarely XX seen in the general population and which often persist their XX entire life. This infection is characterized by either flat XX warts or pigmented (red or reddish-brown) macular plaques. XX Most often these warts are benign but occasionally they progress XX to malignancy. Ultraviolet light may be a cofactor in this XX progression. Benign lesions are associated with diverse EV HPVs, XX while in about 90% of cases cancers harbor HPV-5 or HPV-8. Studies XX indicate that carcinoma develops in approximately one-third of all XX EV patients. It is also interesting to note that other XX immunocompromised patients, such as renal allograft recipients and XX HIV positive patients, suffer from infection of EV HPV types and XX these infections have been known to progress to malignancy. XX XX FT KEY Location/Qualifiers FT CDS 200..646 FT /note="putative" FT /note="ORF E6 from bp 194 to 646" FT /product="transforming protein" FT /gene="E6" FT /note="putative" FT /codon_start=1 FT CDS 643..924 FT /note="putative" FT /note="ORF E7 from bp 595 to 924" FT /product="transforming protein" FT /gene="E7" FT /note="putative" FT /codon_start=1 FT CDS 917..2734 FT /note="putative" FT /note="ORF E1 from bp 842 to 2734" FT /product="replication protein" FT /gene="E1" FT /note="putative" FT /codon_start=1 FT CDS 2676..4061 FT /note="putative" FT /note="ORF E2 from bp 2652 to 4061" FT /product="regulatory protein" FT /gene="E2" FT /note="putative" FT /codon_start=1 FT CDS 3199..3816 FT /note="putative" FT /note="ORF E4 from bp 3172 to 3816" FT /gene="E4" FT /note="putative" FT /codon_start=1 FT CDS 4129..5730 FT /note="putative" FT /note="ORF L2 from bp 4096 to 5730" FT /product="minor capsid protein" FT /gene="L2" FT /note="putative" FT /codon_start=1 FT CDS 5745..7268 FT /note="putative" FT /note="ORF L1 from bp 5664 to 7268" FT /product="major capsid protein" FT /gene="L1" FT /note="putative" FT /codon_start=1 FT source 1..7434 FT /organism="Human papillomavirus type 9" FT /sequenced_mol="DNA" XX SQ SEQUENCE 7434 bp; 2363 a; 1393 c; 1654 g; 2024 t; ccgcaggcaa ccgccaattt cactgccaag gttcgttggc agaccgtcct ggcttcaaaa 60 cgaccgataa cggtaagtct tggcacgtag gtggttattt gatcgttggg atgattgtgg 120 ttaacaacaa tctacataca cattttcata tgaccgcctt cgttaataag cttatataga 180 cataaatata taaggtgcca tgtatttaac agagcagatt atggacaggc caaaacctag 240 aacagtaaag gaactagcag acactcttgt gattccttta atagatttgt tgataccttg 300 taaattttgc aatagatttt tatcttattt tgagctactt aattttgatc acaagtgttt 360 acagcttatt tggacagagg aggatttggt gtatggactc tgtagtagct gtgcttatgc 420 gtctgcacag ttagaattta cacatttttt tcaatttgct gtagttggaa aagatataga 480 aactgtagaa ggaacagcta ttggaaatat ttgtattagg tgtcgctact gttttaagtt 540 attagactta gtggagaagt tagctacatg ctataagttt gagcagtttt ataaggtcag 600 aaacagctgg aaaggattgt gcagacactg tgggtcggta gaatgattgg gaaagaagct 660 actataccag aggtggttct agaactgcaa gagcttgtcc aacccactgc tgacctgcat 720 tgttacgaag aattgacaga agaacctgca gaggaggagc agtgtctcac tccctacaag 780 atcgtagctg gctgtggttg cggtgcaaga cttcgtttat acgtgcttgc tacaaattta 840 ggaattcgag cgcaacagga acttttgctg ggtgatatac aactggtgtg tccggagtgc 900 cgaggcagac ttcgccatga gtgacaataa aggtactaaa ttagatccta aagaatgctg 960 tagtgcttgg ttatcgttag aagcagaatg ctctgattct agtttagatg gtgatttgga 1020 aaaattattt gacgaaggga cagactctga tatttcagac ctaatagatg atggagatgc 1080 tgtacaggga aactcccgcg aactgttttg ccagcaagag agtgaggaaa gcgagcaaca 1140 aacacaattg ctaaaacgaa agtatatcag tccccaagct gttttgcagc ttagccctca 1200 actggagtct atctctttgt cgcctcagca taaacctaaa aggagattat ttgaacaaga 1260 cagcggacta gaatgttctg taaatgaagc tgaagatctt tctgaaacac aggtggaaga 1320 ggtaccggcc aatccaccaa caacagctca gggaactaag ggcttgggaa ttgttaaaga 1380 tttacttaaa catagcaatg tgaaagctgt attaatggct aagtttaaag aggcgtttgg 1440 tgtggggttt gctgagctaa caagacaata taaaagtaac aaaacatgct gtagagattg 1500 ggtaattgct gtgtatgctg tgaatgatga cttaattgaa agctctaaac aattgttatt 1560 gcagcattgt gcttatattt ggctacatta tatgccacca atgtgtttat atttattatg 1620 ttttaacgta ggcaaaagta gagaaactgt atgtagacta ttaagcactt tgctgcaagt 1680 atctgaagtg caattattaa gtgagcctcc aaagttgcga agtgtgtgtg ctgcattatt 1740 ttggtataaa ggaagtatga accctaatgt atacgcacat ggtgcgtatc ctgaatggat 1800 acttacacaa acactaatta atcaccaatc tgcaaatgct acacaatttg acttatcgac 1860 aatgatacaa tttgcctatg atcatgaata ttttgatgaa gctaccattg catatcaata 1920 tgcaaagctg gctgaaacag atgctaatgc cagggctttt ttacaaagta acagtcaagc 1980 cagactagta aaagaatgtg caaccatggt gagacattac atgaggggag agatgaaaga 2040 aatgagtatg tccacatgga tacatagaaa actgcttaca gtggaaagca atgggcaatg 2100 gtcagatata gtacggttta ttagatacca ggatattaat tttattgaat ttctaacagt 2160 atttaaagca tttctgcaaa acaaaccaaa gcaaaactgt ttattatttc atggaccacc 2220 tgacacggga aaatcaatgt ttacaatgtc actaatatct gtgttaaaag gaaaggtact 2280 gtcatttgcc aattgcaaaa gtactttttg gctacaacct atagctgata ctaaacttgc 2340 tttaattgat gatgtaacac atgtgtgttg ggaatatata gatcagtact taaggaatgg 2400 attggatggc aattatgtat gtttagatat gaaacataga gcaccttgtc aaatgaaatt 2460 tccacccctt atgttaacgt ctaacataga tattactaaa gaccaaaagt acaaatattt 2520 gcacagcaga gttaaatcct ttgctttcaa taacaaattt ccacttgatg ctaatcacaa 2580 accacaattt gaacttactg accaaagctg gaaatctttt tttaaaaggc tttggacaca 2640 gttagatctg agtgatcaag aagacgaggg agaggatgga aactctcagc gcacgtttca 2700 atgcactgca agagacttta atggacctgt atgaatcagg tcgagaggat ctacaaagtc 2760 agattgacca ctggcagact ttaagacaag agcaaatact tttgcattat gccaggaaaa 2820 atggagttat gcgattgggg taccaacctg tacctccgtt ggctaccagt gaacagaaag 2880 ctaaagatgc tattggcatg gttttactat tgcaaagcct tcaaagatca gcttatggac 2940 aggaaccttg gacactggca caaactagtc ttgaggcggt acgcagtcca cctgcatatg 3000 cctttaaaaa gggtccacaa aatattgaag tagtttatga tggagatcct gataatgtta 3060 tgagctatac tatatggaac tttatatatt atcagactgt taatgatact tgggaaaaag 3120 ttcaaggtca cgtggattat tttggagcct attactttga agggactgta aaaacatatt 3180 atattaactt tgacaaagat gcagccaggt atggcagaac tggcgtttgg gaagtgcatg 3240 ttaacaagga cattgtgttt gcccctgtta ctagctcttc gccaccaact ggagacgggg 3300 gagagacctc caagcacacc ctttccaggt cggggtcgcc aacaacatcg cgactccctg 3360 ccaccaccgt gcccaccgga ggatccagga catcatcccg acgataccaa cgaaaagcct 3420 ctagccccac caccaggaag aaaagacaga gacaaggaga aggagaagga gaaggagaag 3480 gagaagaaac caactacagg agacaaaggt ccagatccaa gggtcgaaca gaaaccgaaa 3540 ggggagggga gcgacggaga cgaggaaggt cctcctccgc agactccact acccccaccg 3600 acaggcgaag gggaagggga ggtggaaggg ggcccacgac caggtcccag tcccgttccc 3660 gttcccgctc ccactcccgg tcgcggtccc gaggagggac tgcttccagg gttggcgtct 3720 cgcctgatga agtgggaaca cgagttcgat cagttggtgc aggacatcac gggagacttg 3780 cacgattact ggctgaggct aaagaccccc cattaatgct gttgcgtggc gacgccaatg 3840 tgcttaagtg ctatcgcttt cgggaacgca aaaaaaaaag aggcttagta aaatattata 3900 gtactacgtg gtcatgggta ggggaagaca gttgtgatag agttggaaga gcgcgaatga 3960 ttttagcctt tgacacatat gagcacagac aacaattcat taggactatg aaattaccac 4020 ctacagtaga ttggtcttta ggaaatgttg atgatctgta agctttacta acgctaacgc 4080 tggcattgct actaacccat actaactaac aaacccatac taactaacat ggttcgtgca 4140 aaacgtacta aacgtgcctc tgttacagat atatacagag gctgcaaagc tgctggtaca 4200 tgtccaccag atgtaattaa taaagtggag cacacaacta ttgctgataa aattttgcaa 4260 tatggaagtg ctggtgtgtt tttcgggggc ttgggaataa gtacaggccg tggcactggt 4320 ggtgccactg gctatgttcc attaggggaa gggccaggag tccgtgtagg tggcaccccc 4380 actatagttc gccctggggt gatacctgaa ataattggcc caactgatct aattccttta 4440 gacacagtca gaccaattga ccccacagca cccagtattg tcacaggcac tgacagcact 4500 gttgaccttt tacctggtga aatagaatca attgctgaga tacacccagt accagtggac 4560 aatgctgtag tagatactcc agttgtaaca gaaggtagaa gaggctcgtc tgccatttta 4620 gaggtggctg acccaagccc tcctatgcga acccgtgttg cacgaactca ataccataat 4680 ccagcttttc aaattatttc tgagtctaca cctatgtcag gtgaatcttc cttagcagat 4740 catattatag tttttgaagg atctgggggc cagctagtag gtggtcctag ggaatcatac 4800 acagcatctt ctgaaaacat agaattacaa gaatttccta gtagatatag ttttgaaata 4860 gatgaaggaa cacctcctcg gactagtaca cctgtccaaa gagcagtaca atcattatct 4920 agtctgcgta gagctctata taacagacgt cttacagaac aagtggctgt gacagatcca 4980 ttatttttaa gtaggccttc tcgtttagtt caatttcagt ttgataatcc agcatttgaa 5040 gatgaggtca cacaaatatt tgaaagagat ctaagtactg ttgaggagcc tccagatagg 5100 caatttttag atgtacaacg ccttagtagg cctttatata cagaaacacc tcagggatat 5160 gttcgggtta gtagactagg ccgaagagca acaatccgca cacgtagtgg tgcacaggtg 5220 ggcgcacagg ttcatttcta cagggactta agcaccatta acacagaaga acctatagaa 5280 atgcaattat tgggggaaca ctcaggtgac agtaccatag tacaaggccc agttgaaagt 5340 tcaattgttg atgttaatat tgatgaacct gatggtttgg aggtgggaag acaggaaacc 5400 ccttctgttg aagatgtgga ttttaattct gaagacttac tgttagatga gggtgtagaa 5460 gattttagtg ggtctcagct agtcgttggc acacgccgca gtacaaatac attaacagtg 5520 ccacgctttg aaactccaag ggacactagt ttttatattc aggatataca aggctacaca 5580 gtgtcctatc ccgagtctag acaaaccaca gatataattt ttccacatcc tgacaccccc 5640 acagtagtaa tccacatcaa tgatacatca ggagattatt atttacaccc aagtctccaa 5700 aggaaaaaac gcaaacgcaa atatttataa ttttgttttt gcagatgtca ttgtggcttc 5760 cagcaagtgg taaggtatat ttgccaccag caacaccagt ggcgagagtt caaagcaccg 5820 atgaatatgt ggaaagaaca aatatttttt atcatgcaat tagtgaccgt ttgctaacag 5880 tgggtcatcc atattatgat gtccgctcag gcgacggaca aaggattgaa gtccctaaag 5940 tgtctggtaa tcagtatcgg gcctttagaa ttagcttacc tgatccaaat aggtttgctt 6000 tagcagatat gtcagtttat aatcctgata aggaacgtct agtttgggcc tgtagaggta 6060 ttgaaatagg cagaggacaa cctttagggg ttggaacatc aggtcaccca ttatttaata 6120 aggttagaga cacagaaaac tctagcaatt atcaaggcac aacaatggat gacaggcaaa 6180 acacatcttt tgaccccaaa caggtacaaa tgttcattat aggatgtatt ccatgcttag 6240 gagaacactg ggataaagcc aaagtgtgtg aaaaggatgc taataatcaa ctaggcttat 6300 gtcctcctat agaattaaga aacacagtaa ttgaggatgg ggacatgttt gatattggat 6360 ttggaaatat caacaataag gaactgtcct ttaataagtc tgatgtaagc ttagatattg 6420 ttgatgaaac ctgcaaatat ccagactttc taacaatggc aaatgatgtt tatggagatg 6480 catgtttctt ttttgcaaga agagaacaat gttatgccag gcattattat gttagaggag 6540 gttcagttgg tgacgctgtt cctgatggtg cagtaaacca ggatcataat ttctttttgc 6600 cagcaaaaag tgatcaacaa caacgaacaa tagctaattc cacctactat cctacagtaa 6660 gtgggtcatt agtaacttca gatgctcaat tgtttaatag gccattttgg ctccaaagag 6720 cacaaggtca caacaatggc attttatggg gtaatcagat atttgttaca gtggcagaca 6780 atacacgtaa caccaatttt accattagtg tgtctacaga ggcagctcaa acagaagaat 6840 ataatgccaa taatattaga gaatatttaa gacatgttga agaatatcag atttcattaa 6900 tcttacagtt gtgtaaagtg cctttagtag ctgaagtatt atcccagata aatgcaatga 6960 actcaggtat tttagaggat tggcaattag ggtttgttcc aactcctgaa aatgctgttc 7020 atgatatcta cagatatatt gattcaaaag ccacaaaatg cccagatgct gttgagccta 7080 cagaaaaaga agatcccttt gccaaatact cattttggaa agtggatcta actgaaagat 7140 tatcgttgga tcttgatcaa tatcctttag gtagaaaatt tctttttcaa gctggtttgc 7200 aaacacgaaa acgtcctatt aaaacatctg ttaaaacatc taaaaatgct aagagaaggc 7260 gaacctaacc gatatcggtt tccaataaaa tttaagttat ccaatttggt atgtgaagca 7320 ttttttaacc atcttcgtga ctaaaccgta caagtcaaca cagagcgacc gcacccggtt 7380 tatctgatta taaagtgcac ctggtgcaat ttgaacaata ctatcgtgga atca 7434 //