ID HPV5 STANDARD; ds-DNA; VRL; 7746 bp. XX DE Human papillomavirus type 5 (HPV-5), complete genome. XX AC M17463 XX DT 30-SEP-1988 XX OS Human papillomavirus type 5 DNA recovered from a benign flat wart from OS an EV patient. OC Human papillomavirus;Viridae; ds-DNA nonenveloped viruses; OC Papovaviridae;Papillomavirus. XX RN [1] RP 1 - 7746 RA Zachow,K.R., Ostrow,R.S. and Faras,A.J; RT "Nucleotide sequence and genome organization of human papillomavirus RT type 5;" RL Virology 158, 251-254 (1987). XX XX Created by HPV database on 21-APR-1995 from GenBank: M17463. XX XX Draft entry and printed copy of sequence for [1] kindly provided by XX R.S.Ostrow, 10/23/87. XX XX HPV-5 is most often isolated from the pityriasis versicolor-like XX macular lesions of epidermodysplasia verruciformis (EV). HPV-5 has XX been found in both benign lesions and squamous cell carcinomas. EV XX is a rare genetic disease which is thought to be autosomal XX recessive, although a few single cases of X-linked inheritance have XX been reported. This genetic defect results in a patient who is XX immunotolerant. These patients are then infected by HPV types which XX are rarely seen in the general population and which often persist XX their entire life. This infection is characterized by either flat XX warts or pigmented (red or reddish-brown) macular plaques. XX Most often these warts are benign but occasionally they progress XX to malignancy. Ultraviolet light may be a cofactor in this XX progression. Benign lesions are associated with diverse EV HPVs, XX while in about 90% of cases cancers harbor HPV-5 or HPV-8. Studies XX indicate that carcinoma develops in approximately one-third of all XX EV patients. It is also interesting to note that other XX immunocompromised patients, such as renal allograft recipients and XX HIV positive patients, suffer from infection of EV HPV types and XX these infections have been known to progress to malignancy. XX XX FT KEY Location/Qualifiers FT protein_bind join(7741..7746,1..6) FT /function="gene regulation" FT /bound_moiety="E2 protein" FT /note="putative" FT polyA_signal 146..151 FT /note="putative" FT TATA_signal 152..158 FT /note="putative" FT TATA_signal 154..160 FT /note="putative" FT TATA_signal 156..162 FT /note="putative" FT TATA_signal 158..164 FT /note="putative" FT TATA_signal 160..166 FT /note="putative" FT CDS 200..673 FT /note="ORF E6 from bp 167 to 673" FT /product="transforming protein" FT /gene="E6" FT /note="putative" FT /codon_start=1 FT CDS 663..974 FT /note="ORF E7 from bp 618 to 974" FT /product="transforming protein" FT /gene="E7" FT /note="putative" FT /codon_start=1 FT CDS 961..2781 FT /note="ORF E1 from bp 913 to 2781" FT /product="replication protein" FT /gene="E1" FT /note="putative" FT /codon_start=1 FT CDS 2723..4267 FT /note="ORF E2 from bp 2699 to 4267" FT /product="regulatory protein" FT /gene="E2" FT /note="putative" FT /codon_start=1 FT CDS <3285..4022 FT /note="ORF E4 from bp 3285 to 4022" FT /gene="E4" FT /note="putative" FT /codon_start=1 FT CDS <3406..3912 FT /note="ORF E5 from bp 3406 to 3912" FT /gene="E5" FT /note="putative" FT /codon_start=1 FT protein_bind 3537..3548 FT /function="gene regulation" FT /bound_moiety="E2 protein" FT /note="putative" FT CDS 4348..5904 FT /note="ORF L2 from bp 4240 to 5904" FT /product="minor capsid protein" FT /gene="L2" FT /note="putative" FT /codon_start=1 FT polyA_signal 4438..4443 FT /note="putative" FT CDS 5917..7467 FT /note="ORF L1 from bp 5905 to 7467" FT /product="major capsid protein" FT /gene="L1" FT /note="putative" FT /codon_start=1 FT polyA_signal 6289..6294 FT /note="putative" FT protein_bind 7564..7575 FT /function="gene regulation" FT /bound_moiety="E2 protein" FT /note="putative" FT repeat_region 7703..7730 FT /rpt_type=tandem FT /rpt_unit=7703..7717, 7716..7730 FT /note="putative" FT source 1..7746 FT /organism="Human papillomavirus type 5" FT /sequenced_mol="DNA" XX SQ SEQUENCE 7746 bp; 2376 a; 1547 c; 1736 g; 2087 t; aacggtaagt tgcaatttcc ttgtaccagg tgcggtattg ggatttcaca attataatgg 60 ttgttgccaa ctaccatagg catattcaag tttttgcctg tatcgttttc gtatcctgta 120 ataatatcca atatatgtat acataaataa atatatatat atataagtgt ctaagattgg 180 gttcttctgt aatcaggcaa tggctgaggg agccgaacac caacagaaac tgacagaaaa 240 agataaggca gaattacctt taagtattag agacttagct gaagccttag gcatccctgt 300 gattgattgt ttaatacctt gcaatttctg tggcaacttt ctaaattatt tggaagcttg 360 tgaattcgac tacaaaaggc ttagtctaat ttggaaagat tattgtgtgt ttgcgtgctg 420 tcgcgtatgc tgtggcgcca ctgcaactta tgaatttaac caattttatg agcagacagt 480 gttaggaaga gatattgaat tagcttcagg actttcaata tttgatattg atatcaggtg 540 tcaaacttgc ttagcatttc ttgacattat agaaaagtta gattgctgtg gcagaggcct 600 tccctttcat aaggtgagga acgcctggaa gggaatctgt aggcagtgta agcattttta 660 tcatgattgg taaagaggtc accgtgcaag atattattct ggagctcagt gaggtgcagc 720 ccgaagtgct accagttgac ctgttttgtg aagaggaatt accaaacgag caggaaacgg 780 aggaggagcc tgacaacgaa aggatctctt acaaagttat agctccgtgc ggttgcagga 840 actgtgaggt caagcttcgc atttttgtcc acgccacaga atttggtatt agagctttcc 900 aacagctact gaccggagat ctgcagctcc tgtgccctga ctgtcgcgga aactgcaaac 960 atgacggatc ctaattctaa aggtagtaca tctaaagaag ggtttggtga ttggtgttta 1020 ttggaagctg actgtagtga tgtagaaaat gatttgggac aattatttga gagagataca 1080 gactctgata tatcggattt gttagatgat actgaactgg agcagggcaa ttccctggaa 1140 ctatttcatc aacaggagtg tgagcagagc gaggagcaat tgcaaaaact aaaacgaaag 1200 tatcttagtc caaaagctgt cgcacagctt agtccgcgac ttgagtcaat ttcattgtca 1260 ccccagcaga agtctaagcg aaggctcttt gcagagcagg acagcggact cgagctgact 1320 ttaaacaatg aagctgaaga tgttactcct gaggtggagg taccggctat tgactctcgg 1380 ccggatgacg agggaggttc aggggacgta gatatacatt acactgcatt gttgcgttct 1440 agcaacaaaa aagctacatt aatggctaag tttaaagagt cgtttggagt aggttttaat 1500 gaattgacac ggcaattcaa aagccacaaa acctgctgta aggactgggt tgtctctgta 1560 tatgcagtgc atgatgatct atttgaaagc tcaaagcagc tattgcaaca gcattgtgac 1620 tatatctggg tccgtgggat aggtgcaatg tcattatacc tattgtgttt taaggcggga 1680 aaaaatcgcg ggacagttca taagttaatt acctcaatgt taaatgtgca tgaacagcaa 1740 atattgtctg agccgccaaa attgagaaat acagccgctg cattgttctg gtataagggt 1800 tgtatgggat cgggggcgtt tagccatgga ccatatcctg attggattgc ccaacaaact 1860 atattaggtc acaaaagtgc tgaggcaagt acttttgatt tttcagcaat ggtccaatgg 1920 gcatttcata atcacttatt agacgaagca gatatagcat accagtatgc aaggcttgct 1980 cccgaagacg cgaatgcagt agcttggctt gcacataaca accaggccaa atttgtgaga 2040 gaatgtgcat atatggtacg attttataag aagggacaaa tgagagacat gagtatatct 2100 gaatggatat acactaaaat caatgaagta gaaggggaag ggcactggtc agatatagta 2160 aagtttatta gataccaaaa tataaacttt attgtattcc taactgcatt aaaagaattc 2220 ctacactcag tgccaaaaaa aaattgcatt ttaatttatg gtcctccaaa ttctggaaag 2280 tcatcatttg caatgtcatt aataagagtg ttgaagggta gagtgttgtc atttgtaaat 2340 tctaaaagtc agttttggct gcaacccctt tcagagtgca agatagctct attggatgat 2400 gtaacagacc cttgttggat atacatggat acatatttaa gaaatggctt ggatggacat 2460 tatgtttcat tagattgtaa atatagagcc ccaacgcaaa tgaaatttcc cccattatta 2520 ttaacatcta acattaatgt gcatggggaa actaattata gatatttaca cactacaata 2580 aaaggatttg aatttccaaa tccttttcct atgaaagcag ataatacacc tcagttcgaa 2640 ctaactgacc aaagctggaa atcttttttt acaaggcttt ggacacaatt agacctgagt 2700 gatcaagaag aggagggcga ggatggagaa tctcagcgag cgtttcaatg ctctgcaaga 2760 tcagctaatg aacatttatg aagctgcaga acaaacattg caggcacaaa ttaaacattg 2820 gcaaacctta cgaaaagaac ctgtattact ctactatgct agggagaaag gtgttacaag 2880 gcttggatat caacctgtgc ctgtaaaggc agtatcagaa acaaaggcta aagaagccat 2940 agcaatggtg ctgcagcttg agtcactaca gacatctgat tttgctcatg agccatggac 3000 tctagttgat accagcatag aaacatttag aagcgctcca gaaggtcact tcaaaaaagg 3060 ccccctccct gtagaagtta tttatgacaa tgatccagat aatgccaatt tgtatacaat 3120 gtggacctat gtgtattata tggatgcgga tgataagtgg cataaggcaa gaagtggggt 3180 gaatcacatt ggcatttatt atttacaagg aacttttaaa aactattatg tactgtttgc 3240 tgacgatgcg aaaagatatg gtacaactgg agaatgggaa gtaaaagtta ataaggaaac 3300 tgtgtttgct cctgtcacca gctccacgcc tccagggtcg ccaggaggac aagcagacac 3360 aaacaccacc cccgcgaccc ccaccacctc cacaaccgcc gttgactcca cgtccagaca 3420 gctcaccaca tcaaaacagc cacaacaaac cgaaaccaga ggaagaaggt acggacggag 3480 gccctccagc aagtcaagga gatcgcaaac gcagcaaagg cgatcaaggt cccgacaccg 3540 gtcccggtct cggtcccggt cgcggtccaa gtcccaaacc cacaccactc ggtccaccac 3600 caggtcccgg tccacgtcgc tcaccaagac tcgggccctt acaagcagat cgcgatccag 3660 aggaaggtcc ccaaccacct gcagaagggg aggtggaagg tcacccaggc ggcgatcaag 3720 gtcaccctcc acctcctcct cctgcaccac acaacggtca cagcgggcac gagccgaaag 3780 ttcaacaacc agaggggccc gagggtcgag agggtcacga ggagggagcc gtggggggag 3840 agggcggcga cgaggaaggt catcctcctc ctcctccccc gcccacaaac ggtcacgagg 3900 ggggtctgct aagctccgtg gcgtctctcc tggtgaagtg ggagggtcac ttcgatcagt 3960 tagttcaaag catacaggac gacttggaag attactggaa gaagctcgcg accccccagt 4020 aatcattgtc aaaggggcgg ctaacacact gaaaaatgtc cgcaacagag ctaaaattaa 4080 atacatggga ctgtttaggt catttagtac tacctggtca tgggtggcag gagatggcac 4140 tgagcgtcta ggcaggccca gaatgctcat tagcttttct tcctatactc aaaggagaga 4200 ttttgatgaa gcggtgcgat accccaaagg agttgataag gcctatggca acctggacag 4260 tctttaacat ttactaatgc tgcttttgct actaacatac taacataccc tagcatttta 4320 tatttttttt tacattttgt atttgctatg gcgcgtgcaa aaacggtcaa gcgagactct 4380 gtaactcata tttaccaaac ctgcaaacag gcaggcactt gcccccctga tgttattaat 4440 aaagtggaac aaacaacagt tgctgacaat attttaaaat atggcagtgc tggtgtattt 4500 tttggtggcc ttggtattag tacaggccga ggaactgggg gtgctacagg gtacgtgcca 4560 cttggggaag gtcctggtgt ccgtgtcgga ggaaccccca cggttgtaag gccttccttg 4620 gttcctgaaa caatcgggcc cgttgatatt ttgcccattg atacagttaa ccccgtggaa 4680 cctacagcat catccgtggt ccctctaact gagtccacag gcgctgattt acttccaggt 4740 gaagtagaaa caattgctga aatccatcct gtacctgagg ggccatcagt ggatacccct 4800 gtagttacca ctagcacagg ttccagtgct gttttagagg ttgccccaga gcctattcct 4860 ccaacacggg tcagggtttc acgcacacag tatcacaatc catcttttca aataataact 4920 gagtctactc cagcacaagg ggaatcgtct cttgcagatc acgttttggt gacatcgggt 4980 tctggggggc aacgaatagg gggtgatata actgacataa ttgagttaga ggaaattcct 5040 agtaggtata catttgaaat tgaagaacca actcctccac gccgcagcag tactccattg 5100 ccacgcaatc aatctgtagg ccgtaggagg ggtttctctt tgactaatag acgtttagta 5160 cagcaggtac aagtggacaa tccattgttt ctaactcaac catctaagtt agttcgtttt 5220 gcatttgata atcctgtttt tgaggaagaa gtgactaata tatttgaaaa tgatctggat 5280 gtctttgaag aacctccaga cagagatttt cttgatgtta gggaattggg acgtccacaa 5340 tattctacaa caccagcggg atatgttaga gtaagcaggt tggggactcg agccactatt 5400 cgcactcgct ctggtgcaca gatagggtcg caagtccatt tttacagaga tcttagctct 5460 attaatactg aagatcctat tgaattacaa ttattaggcc aacattcagg tgatgctact 5520 atagtccacg gacctgttga aagcacattt atagatatgg atatttctga aaatccatta 5580 tctgaaagca ttgaagcata ttcacatgat ttattattag atgaaacggt ggaagatttc 5640 agtgggtctc agctggttat aggtaatcga aggagcacaa actcttacac tgttcctagg 5700 tttgaaacta caagaaatgg ttcatactat acacaagaca caaagggata ttatgttgca 5760 tatccagagt cacgtaataa tgcagaaatc atttatccta cacctgatat tcctgtagtc 5820 attatacacc ctcatgacag tacaggggac ttttatttac atcccagtct tcacaggcgc 5880 aaacgtaaaa gaaaatattt gtgatttgca ttcgagatgg cagtgtggca ctcggctaat 5940 ggtaaagtat atcttccacc atcgacaccg gtggccagag tccaaagcac cgatgaatac 6000 attcaaagaa caaatatcta ctatcatgca tttagtgaca gattgttaac tgtaggtcat 6060 ccttatttca atgtatacaa tattaatggt gataagcttg aggttcctaa ggtttcagga 6120 aatcaacaca gagtatttcg cctaaaatta ccagatccta acagatttgc attacctgat 6180 atgtctgttt acaaccctga caaagaacgt ttggtttggg cctgtagagg cttagaaata 6240 ggtaggggcc agccattagg tgtacggagt actggtcacc cttatttcaa taaagtaaaa 6300 gatacagaaa acagtaatgc atacataaca ttttctaaag atgacagaca ggatacatct 6360 tttgatccta aacagatcca aatgtttatt gtaggatgca caccttgcat aggagagcat 6420 tgggataaag ctgttccatg tgcagaaaat gatcagcaaa ctggcctttg tcctcctatt 6480 gaactaaaaa acacatatat acaagatggt gatatggcag acataggttt tgggaacatg 6540 aattttaagg cacttcaaga tagtagatca gatgtcagtt tagacatcgt caatgaaact 6600 tgcaagtatc cagatttttt aaagatgcaa aacgatattt atggcgatgc gtgctttttt 6660 tatgctcgta gggagcaatg ttatgccaga cacttttttg ttagaggggg aaaaactggt 6720 gatgacattc cacgtgcaca aattgacaat ggtacataca aaaatcagtt ttacattcca 6780 ggggctgatg gccaagctca aaagactata ggaaattcca tgtatttccc aactgttagt 6840 ggctcattag tatccagtga tgctcaattg tttaacaggc ccttctggct ccaaagagcc 6900 caaggtcata ataatggcat cctgtgggct aatcaaatgt ttatcacagt ggttgacaac 6960 acaagaaata ctaatttcag tatttctgta tataatcagg ctggagcact aaaagatgtt 7020 gcagactata atgcagatca atttagagaa tatcaaagac atgtagaaga atatgaaata 7080 tctttaattc tacaactctg taaggttcct ttaaaggcac aggtattggc acagatcaat 7140 gcaatgaact cttcgttatt ggaggattgg cagttaggat ttgttcccac tcctgataat 7200 ccaattcagg acacctacag atatattgac tctttggcta cacggtgtcc agataagaat 7260 cctccgaaag aaaaggaaga cccttataag ggcttacatt tttgggatgt agatttaact 7320 gaaagattgt cattagattt agatcaatat tccttaggca gaaaattttt attccaagct 7380 gggttacaac aaacgaccgt taacggtaca aaagcagtgt cttataaagg gtctaataga 7440 ggaacaaaac gcaaacgtaa aaattgaggt ctgaccgaaa gtggtacatt tttataaact 7500 tttacacagt attcaaggaa tgtttgttta ctctgactaa gtataagtct tccaaggata 7560 ccgaccgcac ccggtacact cagtcaagtt gttgccaata tagaatcaga tcagtgccaa 7620 acacaccgtc ttggactcag aacagaccgt gttcgttata acatgctcgg attagggacc 7680 tccccaaaga agatttaatc tacaatcgct tttggcaatc gcatttggca ctgctaaaag 7740 accgtt 7746