ID HPV41 STANDARD; ds-DNA; VRL; 7614 bp. XX DE Human papillomavirus type 41 (HPV-41), complete genome. XX AC X56147 XX DT 04-JAN-1993 XX OS Human papillomavirus type 41 DNA. OC Human papillomavirus type 41 OC Viridae; ds-DNA nonenveloped viruses; Papovaviridae. XX RN [1] RP 1-7614 RA De Villiers,E.M., Hirsch-Behnam,A. and Hirt,L.; RT "Nucleotide sequence of human papillomavirus (HPV) type 41: an RT unusual HPV type without a typical E2 binding site consensus RT sequence"; RL Virus Res. 18, 179-190 (1990). XX XX *source: tissue=facial wart; *source: is_proviral=N; From EMBL XX entry PAP41CG; dated 14-JUN-1991. XX XX HPV-41 was originally isolated from biopsies taken from a XX 15-year-old female patient with facial, peri-anal and foot warts XX (HPV-41 DNA was detected in all three areas). The patient had a XX history of dermatitis atopica since early childhood, but no clinical XX or histological symptoms of EV. XX XX Subsequent screenings of tissues taken from 106 biopsies from XX benign and malignant skin lesions as well as 71 malignant tumors XX from non-cutaneous tissues indicated the presence of HPV-41 DNA in XX two out of ten squamous-cell carcinomas and one out of three XX arsenic keratoses (the latter being regarded as a precursor lesion XX to the former). HPV-41 DNA was not detected in any non-cutaneous XX tissues. XX XX HPV-41 has a strong preferential association with flat warts. Most XX often they are multiple and are found on the arms, face, and around XX the knees. Skin warts are transmitted by direct contact with XX infected tissue or with contaminated objects. A majority of warts XX regress, spontaneously within two years. This is thought to be the XX result of a cell-mediated immune response. XX XX Sequence analysis of HPV-41 reveals it to be highly divergent from XX all other known types. Overall nucleotide similarity to other XX sequenced HPV types is less than 50%, and the highly conserved XX E2 protein binding motif (ACCN6GGT) is found only in a modified form XX in the upstream regulatory region of the genome. (These modified XX sequences have been demonstrated to bind to the E2 protein in the XX BPV-1 genome.) The authors of [1] contend that the following XX features place HPV-41 in an intermediate, yet distinct, position XX between the two major classes of mucosal and cutaneous HPVs: the XX amino-terminal end of the E1 protein is intermediate in length XX between ORF of HPV-41 XX FT KEY Location/Qualifiers FT CDS <3341..3646 FT /gene="ORF E4" FT /codon_start=1 FT CDS 102..572 FT /note="ORF E6 from bp 3 to 572" FT /gene="ORF E6" FT /codon_start=1 FT CDS 551..988 FT /note="ORF E7 from bp 518 to 988" FT /gene="ORF E7" FT /codon_start=1 FT CDS 951..2795 FT /note="E1 ORF from bp 867 to 2795" FT /gene="ORF E1" FT /codon_start=1 FT CDS 979..1212 FT /note="X ORF from bp 922 to 1212" FT /gene="ORF X" FT /codon_start=1 FT CDS 2728..3891 FT /note="E2 ORF from bp 2716 to 3891" FT /gene="ORF E2" FT /codon_start=1 FT CDS 2832..3050 FT /note="Y ORF from bp 2811 to 3050" FT /gene="ORF Y" FT /codon_start=1 FT CDS 3806..4042 FT /note="E5 ORF from bp 3722 to 4042" FT /gene="ORF E5" FT /codon_start=1 FT CDS 3910..5574 FT /note="L2 ORF from bp 3907 to 5574" FT /gene="ORF L2" FT /codon_start=1 FT CDS 5336..7087 FT /note="L1 ORF from bp 5312 to 7087" FT /gene="ORF L1" FT /codon_start=1 FT CDS 5652..5882 FT /note="Z ORF from bp 5631 to 5882" FT /gene="ORF Z" FT /codon_start=1 FT source 1..7614 FT /organism="Human papillomavirus type 41" FT /sequenced_mol="DNA" XX SQ SEQUENCE 7614 bp; 2101 a; 1665 c; 1908 g; 1940 t; acaatcataa tcatcgccct ttcgtgttat ttcttgtaac gaattcgtta caaaacacac 60 acacagtata taagatagag gaacggattg gtacaccaca gatggcatca acaagcggtg 120 tgggatccgt cgggcctgca agctgttgcg agacgcagaa gccacatacc atacgggagt 180 tgtgtttggc gcagcagata acttatccat gcatacagct ctgctgccat tattgctata 240 agatccttag cgtattggat atttacgctt tcgaccagag ctgtctgtac ttatcctggg 300 gagaaggggg gccaacgggt atttgttctc agtgtactag agtgcttgca aggctggagt 360 tcactgcacg gcacgaagtg tcttgtgcag ccagccgtct gccgcacttt ataggacaga 420 gcctcagcga ccttgaggtg aggtgtgtga ggtgcctagc tcttctacaa tctgtggaaa 480 aggattacat attgcgggaa gacttgtctg tgcatagaat tggcgggatc tggaggggaa 540 cttgtgttcg atgtatggta ggactgtatt agctgtgaga ctaatatact gtttgctgta 600 ttgtattgct gtaatcgtgc gtaaattgct ataccctgta ataatgagag ggaatagtgt 660 tgacctgcaa gaaattgtgc ttgttcagca gggggaggta cctgagaatg ctgcagtgca 720 ttcaggggag cattctgatg atgagggtga gagcgaggag gaggagcggg aacaggtgca 780 gcaagtcccc acacccagga gaacattata cctggtagag agtcagtgtc cattttgcca 840 ggctatcata cgatttgtat gcgtagcaag caacactggg atacggaatc tacaggcact 900 cctggtcaac agtcaccttg acctcgcttg tcacgcctgt gtcgagcaga atggcgtcca 960 gggtctcaga caccggcaat ggcaatgaaa acaaagagaa tgaaggtaca gtggcatctg 1020 atcattctga ggcgcgttgt agctatatat tatttgaggc tgaatgtagc gatggcgggg 1080 acgatgagga aagtatggag gatagcttgg tggaagacct tgtggatgat gcttctgtgc 1140 atcagggaaa ttccttgtcg ctgtttcatg cccaaactgt cgaggaatac gagggagaga 1200 tccagagcct aaaacgaaag tttatcctga gtcccttgca tagggatgtg gcagaactaa 1260 gcccgcgtct ggcgggtgtt tccctggaag aaaaccgtgg gaaaaaggct cgcaaatctc 1320 tgttccacga tgacagtggc atagacagca gcgcagtgga agtctcccag ctatctagta 1380 cgccatcagc tccagggcca gacatccggc tgcctaaacc ctcagatata gatctagagc 1440 cactgttcca aagccgccag cgctgtacgc atatgtatag caaatttaaa gctgtgtacg 1500 gggttagctt tacagatata accaggccat tcaaaagcga caaaacaaca tcacagcatt 1560 gggttgtggc cgcctactat ttagcttttg atagtgagat aagtgctatg gaggttttgc 1620 tgcgacaaca atgccaattt ttatacattg acaacaatga tggcattata ctgttcttcc 1680 tggaatacaa cgtgcagaaa tctaggacta cagtgtacaa ttggttcaca gccaatttcc 1740 attataatga aaatagaatg ctagctaatc cgccaaggac acgaaacatg cctgctgctt 1800 tattcttcta tcatagattt atgggtacag ggggtataaa acatggcgca atgccagaaa 1860 taattgtaaa ccagtgcgtg gtgtctaatc agcagacaga cacctttgaa ttatcacgta 1920 tggtacagtg ggcactggac aacgatctgc aagatgaaca tatgttagct ttagagtatg 1980 ctttgcttgc tgaaagtgat ggcaatgcgc gggctttttt aaagcagaat aatcagccaa 2040 tgatagtgaa gaattgtagc ataatggtta gacactacaa gacagcgctg gtcgcaaaaa 2100 tgtctatttc acagtatgtg aataagcggt gtctggacca tggggaagct gatgaaaaca 2160 gctggcgggg aattgtgcat tttctgaggt atcaaggtca ggaattcctg cccttcatgt 2220 gtaaaatgca caatttccta caccatagac caaagaaatc aacacttgta ttatgtggac 2280 cgtcggacac aggcaaatca tattttgcca atggtcttaa caaatttttg gatggacacg 2340 tgctgagctt tgtcagcaat gggtcacatt tttggttatc accattacgt ggggcacggt 2400 gctgtctaat agacgatgcg accctcacgt tttggaggta cgcggaccaa aacatgaggg 2460 cactgctaga tggatatgag atttccattg atgcaaaaca cagaaaccca atgcaaacta 2520 gagcaccacc attaataata accacaaatg aggacattat gcgattagat gaattcaaat 2580 atctgcaaac cagaacaatg tatgtgtact ttaacaagcc atttcctctt aaaggaaatg 2640 ggcaaccgtt atattacatt gatggttata catggaactc tttttttagg aaattttggc 2700 gtcacctaaa tctaaaagac cctgaggatg agtcagatgg agagactcct ggaacgatta 2760 gactatatac aagagcagat actgacacta tatgagaaag atagtgttga cctagaggat 2820 catataaggc tatggaatct gctaaggagg gaaaatgcaa tctggtatgt actcagacag 2880 gaaggacacg caagggtcgg cggcagagcg gtgccggcaa tgacggtatc ggaagccaat 2940 gccaaattcg caatagaaat gcagataaag ctagaatcac taaaggccag tccctatgcg 3000 gccgagggct ggtcattgca agaaaccacc aaggaacggt acttggctga accgtctcgg 3060 acatttaaga aattagggca gccagttacc ctaatgtttg acaatgatcc cgaaaacctt 3120 acagaagttg tattgtggaa atgggtttat tatattacac caacagatga atggtataaa 3180 gctagaggtg gcattgatga cactggtata tactacattg accacgagtc tgttaaaatg 3240 tactatgtga gatttgacat ggaagcggag aactttagcg agacaggcac tgtcacctac 3300 cggctaggca gcgccctggt aaatgtacct gaacctgtaa ctgttaccga cagctcctcc 3360 acgagggaga gaaccccaaa ggtactacga ccgcaggggt cgagacgacg cagaaacgag 3420 gaaacggggg agccggtcgc cccagcccct aagcgaagac gaggagctta cggacgcaga 3480 tcctccccga aggcccaacg caggaccgcg gcgtcgcctg tttctagagg aaacggagga 3540 tcgtctgact tcacttctgg agagtctgac gaaggacatc gagtcagaca tagagcactt 3600 cgaaagaaaa ctgcgggtgt tgctccagca gaaggacact atctagttgg cgccaaaggt 3660 ccagtgaata gcctgcggtg cttaaggtac aaatggaaaa acaagtatag cggtgacata 3720 atgtatctgg ggactacttt cacatggacg gagtctgacg ggacagaacg gtgtgggtcg 3780 gggcgctttt tttgtgcttt ctctaatgaa acaaaaagag aaaagttcct caaatctgtc 3840 aagattccta aaaacattgg gctgtttcgc gcacacgcag aaaagctgtg acctgtgtat 3900 cattaaacaa tgcttgctag gcaaagggtt aaacgcgcta atcctgaaca actgtataag 3960 acatgcaaag caacgggggg cgattgtcca cccgatgtta ttaaacgcta tgagcaaact 4020 acacctgctg atagtatatt aaagtatggg agtgtagggg ttttctttgg cggtctgggc 4080 attggcacag gacgtggtgg cggtggcaca gtgcttgggg ctggggcagt tgggggacgc 4140 ccgtccatat ccagtggtgc aattggtccc cgggatattt tgccaattga atcagggggg 4200 ccttcactgg cagaggaaat acctctgctt cccatggcac cccgtgtgcc aaggcctaca 4260 gatccctttc ggccgtcagt gctggaagag ccttttatta taaggcctcc tgaacgccca 4320 aacattttgc atgagcagcg tttccctaca gacgctgcac catttgacaa tggcaacaca 4380 gaaatcacaa ccattcctag ccaatatgat gttagtgggg gaggggttga cattcagata 4440 attgaactcc ctagtgtgaa tgaccccggt ccctcggttg ttacccgcac acaatacaac 4500 aatccaacgt ttgaggtgga ggtgtccact gacattagtg gagaaacctc atcaacggac 4560 aacattattg taggagctga aagcggtggc acatccgtag gtgacaatgc tgaactgata 4620 cctttgctag atatatcccg gggggacaca attgacacaa caatacttgc ccctggcgag 4680 gaggagactg cctttgtgac cagcactcct gaacgtgtgc ctatacagga gcgattacct 4740 attaggccct atggcagaca gtatcagcaa gtgcgagtta ccgaccctga atttttagac 4800 agcgctgcag tacttgtctc tttagagaat ccagtgtttg atgcagacat tactctcacg 4860 tttgaggatg atctgcagca ggcactacgt agtgacacag acctgcggga cgtgcgtcgc 4920 ctcagtagac cttattacca gaggcgcact actggccttc gtgttagtcg cctggggcaa 4980 cgtcggggta ctatatccac gcgctctggt gttcaggtag gctccgctgc tcattttttc 5040 caggacatta gtccaatcgg ccaggctatt gagccaattg atgcaattga actagatgta 5100 ctgggtgagc aatccggtga ggggactatt gtgagaggag accctacgcc ttctattgag 5160 caagacatag gactaaccgc tttgggggac aacattgaaa atgaattgca ggaaatagat 5220 ttattaactg cggatggtga agaagaccag gagggcagag acctgcagtt ggtattttcc 5280 actggcaatg atgaggtggt tgatattatg actataccta tacgtgcagg cggggatgac 5340 aggccttcag tatttatttt tagcgatgat ggcactcaca ttgtctatcc tactagcaca 5400 acagccacca ccccactcgt gcctgcacag cccagcgatg tgccctacat tgttgttgac 5460 ttgtatagtg gaagtatgga ttatgatata catcctagcc tgttgcgcag gaaacgtaaa 5520 aaacgcaaac gtgtttattt ttcagatggc cgtgtggctt ccaggcccaa atagatttta 5580 cttaccccct caacctatac aacggacatt gaacacagag gaatacgtga gacgcaccag 5640 tactttcctc catgctgcca ctgaccgttt gcttactgtt ggacatccat tttacaatat 5700 tactaatgcg gatggcaaag aggtggtccc taaagtttcc tctaatcagt tcagggcctt 5760 ccgtgtccgt ttcccaaatc ccaatacctt tgcattttgt gataagtccc tttttaaccc 5820 tgacaaggag cgtctggtct ggggtattcg tgggattgag gtttctaggg gacagccctt 5880 aggtattggt gtaacaggga accctttttt taataagttt gatgatgctg aaaatcccta 5940 caatggtata aacaaaaata acattactga ccaaggttca gactcaaggt tgagcattgc 6000 atttgaccct aagcaaacac agctgctgat agtaggtgct aaacctgcaa agggtgagta 6060 ctgggacgtt gctgcaacat gtgaaaaccc tccactgacc aaagcagatg acaaatgtcc 6120 tgctctagag cttaagtcct catacattga ggatgcagac atgagtgaca taggcctggg 6180 aaacttgaat ttttctacac tgcagagaaa caaatccgat gccccattag atattgtgga 6240 ttctatctgc aaatatcctg actacctgca aatgatagaa gaactatatg gagaccacat 6300 gtttttctat gtgcggcgtg aagctctgta tgctaggcat ataatgcaac acgcgggcaa 6360 gatggatgct gagcaatttc ccacttctct gtacatagac tcctctgtag aaggtgagaa 6420 attaaattcc ttgcagcgca ctgataggta tttcatgaca cccagcggct ccctggtagc 6480 tactgagcag cagctgttta acaggccctt ttggctgcag agatcccagg gccataacaa 6540 tggcatactg tggcacaacg aggcctttgt aacattggtt gacactacca ggggaactaa 6600 ctttaccatc agtgttcctg agggggatgc ttcttcatat aacaattcta agttttttga 6660 gtttttaagg cacaccgagg agtttcagct tgcctttatt ctacagctgt gtaaggtaga 6720 ccttacccct gagaatttgg cttacataca cacaatggat ccatccatta ttgaagactg 6780 gcatttagct gtcacttcac ctcccaattc tgtactggag gatcattata ggtacatact 6840 gtccattgca actaaatgtc cctctaagga tgcagatgat acctccactg acccatacaa 6900 agatcttaag ttttgggagg ttgatctacg ggatcgtatg acagagcaat tggaccagac 6960 tccccttggc aggaagtttt tgtttcaaac tggtatcact cagtcatcat caaataagcg 7020 ggtgtccacg cagtctactg cccttactac ctacaggcgg cctactaagc gccgccggaa 7080 ggcttaaacg aattgctggt attgtggtgc ggtgtcctcg acggtccatg tgtcatctta 7140 taatcacttg gtcagtccag ggtacaccac tccattatct atttacttcg catgtatttc 7200 tctgttatgt tcctgtatgg gttatgaatg tgttaataaa atatgttggt aacgctgtgc 7260 acgggtttgt tcacgttcat gtctcatgat ttggcacccc tgtattcccg ccgccgcccg 7320 ggggatcgca gatataatcc ccaaacccaa agcgttccaa cattggcaaa cgtctctggc 7380 cccgatacaa ctgaaacggt ctgtcttgcc aatagcccca tctggcgggg attcaactga 7440 aacggtgtgt actgccaagt aacatttttg ttattggaac gcctccggtg ctggcggaag 7500 cgcaaggatt taggcgcgaa gacagtttta ttgccaaaac cttttggttg ctgccaatag 7560 caggcgtggt ctcaacgaat tcgttgcggc aataggtatg taccatggtt atga 7614 //