ID HPV14d STANDARD; ds-DNA; VRL; 7439 bp. XX DE Human papillomavirus type 14D (HPV-14), complete genome. XX AC X74467 XX DT 04-OCT-1993 XX OS Human papillomavirus type 14D DNA. OC Human papillomavirus type 14D OC Viridae; ds-DNA nonenveloped viruses; Papovaviridae; OC Papillomavirus. XX RN [1] RP 1-7439 RA Egawa,K., Delius,H., Matsukura,T., Kawashima,M. and De Villiers,E.M.; RT "Two novel types of human papillomavirus, HPV63 and HPV65 RT comparisons of their distinct clinical and histological features RT and their DNA sequences to other HPV types"; RL Virology 194, 789-799 (1993). XX XX Submitted (27-JAN-1993) on tape to the EMBL Data Library by: H. XX Delius, Deutsches Krebsforschungszentrum, Abt ATV, Im Neuenheimer XX Feld 506, W -6900 Heidelberg, FRG. Clone = insert in HindIII site XX of pBR322. XX HPV-14 is most often isolated from the flat warts of XX Epidermodysplasia Verruciformis (EV). It has been isolated XX from both benign lesions and squamous cell carcinomas. EV is a XX rare genetic disease which is thought to be autosomal recessive, XX although a few single cases of X-linked inheritance have been XX reported. This genetic defect results in a patient who is XX immunotolerant. These patients are then infected by HPV types XX which are rarely seen in the general population and which often XX persist their entire life. This infection is characterized by XX either flat warts or pigmented (red or reddish-brown) macular XX plaques. Most often these warts are benign but occasionally they XX progress to malignancy. Ultraviolet light may be a cofactor in this XX progression. Benign lesions are associated with diverse EV HPVs, XX while in about 90% of cases cancers harbor HPV-5 or HPV-8. Studies XX indicate that carcinoma develops in approximately one-third of all XX EV patients. It is also interesting to note that other XX immunocompromised patients, such as renal allograft recipients and XX HIV positive patients, suffer from infection of EV HPV types and XX these infections have been known to progress to malignancy. XX XX Due to an apparent deletion of approximately 300 bp, the E6 and E7 XX ORFs of HPV-14d seem to be disrupted. Based on its homology to XX other HPV types, the ORF appearing in the sequence from bp 82 to XX 744 is similar at its 5' end to the beginning of E6, and at its 3' XX end to the end of E7. On this basis, we have chosen to assign bp XX 196-627 to E6 and bp 628-744 to E7. XX XX FT KEY Location/Qualifiers FT CDS 196..627 FT /note="putative" FT /note="ORF E6 from bp 82 to 627" FT /product="transforming protein" FT /gene="E6" FT /note="putative" FT /codon_start=1 FT CDS 628..744 FT /note="putative" FT /product="transforming protein" FT /gene="E7" FT /note="putative" FT /codon_start=1 FT CDS 731..2548 FT /note="putative" FT /note="ORF E1 from bp 641 to 2548" FT /product="replication protein" FT /gene="E1" FT /note="putative" FT /codon_start=1 FT CDS 2490..3941 FT /note="putative" FT /note="ORF E2 from bp 2466 to 3941" FT /product="regulatory protein" FT /gene="E2" FT /note="putative" FT /codon_start=1 FT CDS 2851..3696 FT /note="putative" FT /note="ORF E4 from bp 2848 to 3696" FT /gene="E4" FT /note="putative" FT /codon_start=1 FT CDS 4028..5587 FT /note="putative" FT /note="ORF L2 from bp 3959 to 5587" FT /product="minor capsid protein" FT /gene="L2" FT /note="putative" FT /codon_start=1 FT CDS 5603..7159 FT /note="putative" FT /note="ORF L1 from bp 5588 to 7159" FT /product="major capsid protein" FT /gene="L1" FT /note="putative" FT /codon_start=1 FT source 1..7439 FT /organism="Human papillomavirus type 14d" FT /sequenced_mol="DNA" XX SQ SEQUENCE 7439 bp; 2337 a; 1432 c; 1612 g; 2058 t; aacggtaagt tattctgcac cgggtgcggt cactgtatta ctcactatgt ggttgttgtt 60 gccaactacc attgctgata gcatgttttt gcctgtaacg ttatcgacac atacatatct 120 atgtatatat atatatatat atatatatat atatatatat atatatacta cagaaaaaac 180 agagaatgca gactcatggc gacaactgac tcttcaacag acagtgcaga tgaaggtcct 240 tctcctaaga gtaactattg tgatagcaca gaaaccaaat cttcttttat agagccacca 300 ttacctgcaa ctatatttgg cttagcaaac ctattggaaa taccactaga tgattgttta 360 gtaccttgta acttttgtgg taattttttg actcatttag aagtctgtga atttgatgag 420 aaaaaactaa gtctaatttg gaaaggtcat tgtgtatttg cttgttgccg tgtatgctgc 480 acagcaacag caacgtatga gtttaatgaa ttttatgaga gtactgttga aggcagagaa 540 atagagagtg taacaggcaa atctattttt gatgttgatg tcaggtgcta tacctgcatg 600 aaatttttag attcaattga aaagcttcgc atctttataa ctgctacaga atttgctctt 660 agaaccttcc agaacctgtt atttgaacaa ctgcagctgt tgtgtcctga gtgccgtggg 720 aactgcaaac atggcggatc ctaaaggtag tacatctaaa gacgggttgg atgattggtg 780 tattgtggaa gctgaatgta gcgatataga aaatgatttg gaagaattat ttgacagaga 840 tacagactca gatatttcag aattattaga tgataatgat gacttggacc agggaaattc 900 tcgggaacta tttcatcaac aagagagtaa ggaaagcgag gagcacttgc aaaaactaaa 960 acgaaagtac ttgagtcctc aagctatcgc acagcttagt ccgcgacttg aaagtataac 1020 attgtcacct cagcagaagt ctaaacgaag gctctttgca gagcaggaca gcgggttgga 1080 gttaactctt acaaatgaag ctgaagatgt ttcttctgag gtggaggtac cggctctaga 1140 ctctcagccg gttgctgagg cacaaatagg aacagtagac attcattata cagaattatt 1200 acgtgccagc aacaataagg caattcttat ggcaaaattt aaggaggctt ttggggtagg 1260 ctttaatgat ttgacacgtc agtttaaaag ttacaaaacc tgctgtaatc attgggttct 1320 gtctgtatat gcagtgcatg atgatcttct tgaaagctca aagaagttat tgcaacagca 1380 ttgtgattat gtatggatac gtgggatagc tgctatgtca ttatttttat tgtgtttcaa 1440 agtgggaaaa aatcgtggga cagtacataa attaatgacc tcaatgttaa atgtgcatga 1500 aaagcaaata ttgtctgagc ctccaaagct acgaaatgtt gctgctgcat tgttctggta 1560 taaaggtgca atggggtcag ggacatttac ttatggtccc taccctgatt ggatggcaca 1620 tcaaactatt gttggccatc aaagtacaga agcaaatgca tttgatatgt ctgttatggt 1680 gcagtgggca tttgataaca attatttaga tgaagctgat atagcctatc aatatgctaa 1740 gttagcacca gaagatagta atgctgtggc ctggcttgcc cataataatc aggccaggtt 1800 tgttagagaa tgtgcatcta tggttagatt ttataaaaaa ggtcaaatga aagaaatgtc 1860 tatgtcagaa tggatacata ctagaataac tgaagtagaa ggagaaggtc attggtcaac 1920 aatagcaaaa tttcttagat atcaacaagt aaactttata atgtttttag ctgctttgaa 1980 agatatgcta cattcagttc ccaaacgtaa ttgtatatta atatatggtc ctccaaatac 2040 tgggaagtca gcatttacca tgtctttaat tcgtgtgtta agaggaaggg tgctttcatt 2100 tgttaattct aaaagccaat tttggctgca accaatgtca gagtgtaaaa tagctttaat 2160 tgatgatgtc acagatccat gttggttgta tatggacact tatttgagga atggccttga 2220 tggtcattat gtttctttag attgcaaaca taaagcaccg atacaaacta aatttcctgc 2280 actattactt acatctaata ttaatgtaca caatgaaata acgtatagat atttgcatag 2340 tagaattaag ggatttgaat ttccaaatcc atttccaatg aaagcagaca atacacctga 2400 atttgaactc actgaccaaa gctggaaatc tttctttaca aggctttgga atcaattaga 2460 gctgagtgac caagaagacg agggagacaa tggagaatct cagcgaccgt ttcaatgctc 2520 tgcaagatca gctaatgaac atttatgaga ctgcagcaaa cacacttgag tcgcaaattg 2580 agcattggca aactcttcga aaagaagctg tgctactata ttttgctagg caaaatggtg 2640 tgacacgact tggataccaa gttgtgccta cattagccat ttcagaagca aaagccaagc 2700 aggccatagg gatggtgctg cagttgcaat cactgcaaaa gtctcagttt ggcagtgaac 2760 catggtcact ggttgatacc agtggagaaa catttagaag tgctccagaa aatcatttca 2820 aaaagggtcc agtatcagta gaggtgattt atgataacga taaagacaat gcaaatgctt 2880 atactatgtg gaagcacata tattaccagg atgatgacga acagtggcat aaaagtgcaa 2940 gcggggtcaa ccacacaggc atatattata tgcaaggaac ctttagaaac tactatgttt 3000 tgtttgctga tgatgcaact agatatagta aaactggaca ttgggaagtt aaagttaata 3060 aggaaactgt gtttactcct gtcaccagct ccacccctcc cgagtcacca ggaggacaag 3120 cagactcaaa cacctcctcc aagaccccca ccaccgccac tgactccacg tccagactct 3180 cgcccgcaga ttccagaaaa cagtcacaac aagccaacac caaaggaaga aggtacggac 3240 gcagaccgtc cagtaggacc cggcgaacga ccgaaacgcg gcagaggcgg agatcgaggt 3300 ccaagtccag gtcgcggtcg aggtcgcggt ctcggctccg atctagatcc cggtcgcaat 3360 cgtctgagcg gcggtctcgg taccgatcaa gatccagatc cagacaaaaa gaagtgtcca 3420 gaatcacaac caccaccaga gggagaggtc gagggtcatc ctccacctcc tccaaacggt 3480 cacaacgggc acgaggaagg ggccgtgggg ggagcagggg gagacggtca tcctccacct 3540 cccccacctc ctccaaacgg tcacgacgag agtcagagtc ttctaggcag cgtggcatct 3600 ctcctagtga cgtgggaaag tcacttcaat cagttagttc aagaaataca ggaagacttg 3660 gaaggttact ggacgaagct ctcgatcccc cagtaatctt agtcaggggg gaccctaaca 3720 cgctacgatg ctttcgcaat agagctaagc aaaagtttac agggctttac agggccttta 3780 gcacggcttg gtcgtgggtg gctggagatg gcactgagcg tctaggcagg tccagaatgc 3840 tcattagctt tttctccttt aaccagagaa gagattttga tcagactgtt aagtacccga 3900 aaggagtgga ccggtcgttt ggctcatttg atagcctata acacccctaa catactaaca 3960 taatagcttg ctactaacat ctaacattta ttgcattttt gctttttgtt tgcattattt 4020 taatgctatg gcgcgtgcta ggcgagtcaa gcgtgactct gctactaaca tttacagaac 4080 ctgcaagcaa gcaggcacgt gtcctcctga tgtcattaat aaagttgaaa gcacaactat 4140 tgctgataaa attttgcagt atggtagtgc tggtgttttt tttgggggtt tgggcataag 4200 cactggaaaa ggtacaggag gtaccacagg ctatgtgcct ttgggagagg gcccagcagt 4260 acgtgttggt ggtgcgccaa caattatcag acctgctctg gtcccagaca ccattggtcc 4320 atcagatatt atacctgtgg acaccttaga tccagtggag cctacgacct cttctattgt 4380 tccactcacg gattccacag gaccagacct tttgcctggc gaggtggaaa ctattgcaga 4440 ggtgcatcct ggcccgtcta ggcctcctac tgacactcct gtcacaacta gtacaggagg 4500 ctccagtgct atattagaag tagcaccgga acctactccg ccctcacgtg ttagggtgac 4560 ccggacacaa tatcataatc cctcctttca agtaattacc gaatccaccc ctaccacagg 4620 tgaaagttca ttagcagaca atatattggt tacctctggt tctgggggac aaactattgg 4680 aggcgctaca cctgaactta tagaacttca agagttacca tctagatatt catttgaaat 4740 cgaagaacca acacccccta gaagaactag taccccatta caaaggatac agacagctat 4800 aagaaggagg ggtgggctta caaataggcg cttagtccaa caagtttctg tagaaaaccc 4860 cttattttta acaagaccat ctagactagt gcaatttcag tttgataatc cagcatttga 4920 ggaggaagta acacaaatat ttgaacaaga tattgaagat tttaatgagc ctccagacag 4980 agattttcta gatgttcaaa ggctgggtag gccccaatat tcagaaactc cagcagggta 5040 tctccgagtt agtcgtcttg ggcaaaggcg gactatacgc actcgttctg gagcacaaat 5100 tgggtctcaa gttcattttt atagagatct aagtagtata aacacagaag atcctattga 5160 gcttcaatta ttaggtcagc attctgggga tgctactatt gtccaaggtc cagttgaaag 5220 cacatttgta gacataaatg tagatgaaaa tccactttct gaggatttta gtgcacattc 5280 tgatgacttg cttttagatg aagctaatga agactttagt ggctctcaat tagttgtggg 5340 taatcgacgc tcaacatctt catataccgt ccctcgtttt gaaacaacca gatctgggtc 5400 atattatgca caggatacaa aaggttatta tgtagcttat cctgaggata gggacattag 5460 catggatatt atttatccta ccccagagtt gcctgttgtc attattcaca catatgatac 5520 aagtggtgat ttttacctgc atcctagtct tcacaaaaga ctcaaaagaa aacgaaaata 5580 tttgtaactt tttcttttac agatggcagt ttggcaagca gctagtggta aggtttacct 5640 tccaccatct acaccagttg ccagggtcca aagtacggac gaatatgtgc aaaggactaa 5700 catctattat catgcataca gtgacagatt attaactgtt ggtcatccat atttcaatat 5760 atatgacgtg caaagtgcta agataaaagt accaaaagta tctggaaatc aacatagggt 5820 tttcagacta aagttgccag accctaatcg atttgcatta gctgacatgt ctgtttataa 5880 tccagataaa gaaagactgg tttgggcatg cagaggtata gaaataggca gaggacaacc 5940 tttaggtgta ggtagtgtag gacatccatt atttaataag gttggtgata cagaaaatcc 6000 caactcatac aggcaacaag ctaactccac tgatgacaga caaaatgtgt catttgatcc 6060 taagcaactg caaatgttta taataggctg tgcaccttgc atgggggaac attgggatag 6120 ggccttgcca tgtgtagaag ataaaccacc ccctggttct tgccctccaa ttgaattaaa 6180 aaatacagtg attgaagatg gtgacatggc agatataggc tatggaaatt taaattttaa 6240 ggcattacaa gaaaatagat ctgatgtaag tttggatata gttaatgaaa tttgcaaata 6300 tccagacttt ctgaaaatgc aaaatgatgt atatggagat tcctgctttt tttatgcacg 6360 cagggaacaa tgttatgcca gacacttttt tgttagaggg ggtaagacag gagatgacat 6420 accagcagca caagttgatg agggtagcct aaagaatgtt tattacattc caccaatgac 6480 aaatcaacca caaaacaata ttggcaatgc catgtatttc ccaactgtca gtggctcatt 6540 ggtatccagt gatgctcaac tgttcaatag accattttgg ttacagcgcg cacaaggcca 6600 caataatggt atttgttggt ttaatcagtt atttgttact gttgtggaca acacacgtaa 6660 cacaaatttt agtatatcag ttagttcaga aaacactgag gtatccaaaa ttgacaatta 6720 tacctctcag aaatttcaag aatatttaag acatgtagaa gaatatgaaa tgtctctaat 6780 tttacaacta tgtaaaatac ctttaacagc tgaagtctta gctcaaatta atgcaatgaa 6840 ttctaatatt ttagaggagt ggcaattagg atttgtacct gcaccagaca atcctattca 6900 tgatacatac agatatattg agtctgcagc gactaggtgt cctgataaaa atcctcctaa 6960 agaaagagaa gatccttata aaaactttaa cttttggaat gtagatttaa cagagagact 7020 atctttagac ctagatcaat attctcttgg gagaaaattt ttatttcagg caggtttgca 7080 gcaatcgacc gttaacggta caaaaacagt ttcgactagg ggatccatca agggtattaa 7140 acgaaaacgc aagaattaga cattatcgat ttcggtgcaa taaagtcaac ttttacacag 7200 tattcaagga atgtttattc actctgacta agcaaatatg agccgcgccc gatacataaa 7260 ggtgccaaat gaggtgagtt gtttgccaga agaggtcaga gccaactcag gtttgcgcca 7320 gatcagatac agcgcgagcc gcgttggatc aagctacatc gtctgaacac gcaaaagact 7380 caaggaaatg taagtgtgcc agtctattgt gttcgaattt ggcaaagttg aagaccgtt 7439 //