ID TNF STANDARD; ds-DNA; PRI; 7112 bp. XX DE Human tumor necrosis factor and lymphotoxin genes, complete cds. XX AC M16441 XX DT 15-JUN-1989 XX OS Human placenta DNA, clone pTNF186. OC Homo sapiens OC Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria; OC Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. XX RN [1] RP 1-7112 RA Nedospasov,S.A., Shakhov,A.N., Turetskaya,R.L., Mett,V.A., RA Azizov,M.M., Georgiev,G.P., Korobko,V.G., Dobrynin,V.N., RA Filippov,S.A., Bystrov,N.S., Boldyreva,E.F., Chuvpilo,S.A., RA Chumakov,A.M., Shingarova,L.N. and Ovchinnikov,Y.A.; RT "Tandem arrangement of genes coding for tumor necrosis factor RT (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome"; RL Cold Spring Harb. Symp. Quant. Biol. 51, 611-624 (1986). XX XX Draft entry and computer-readable sequence for [1] kindly submitted XX by C.V.Jongeneel, 02-OCT-1988. XX FT KEY Location/Qualifiers FT prim_transcript 819..2855 FT /note="lymphotoxin mRNA and introns" FT intron 980..1266 FT /note="lymphotoxin intron A" FT exon <1276..1374 FT /number=2 FT /note="lymphotoxin, (first expressed exon)" FT /gene="TNFB" FT /map="6p21.3" FT CDS join(1276..1374,1461..1566,1814..2226) FT /note="lymphotoxin" FT /codon_start=1 FT intron 1375..1460 FT /note="lymphotoxin intron B" FT exon 1461..1566 FT /number=3 FT intron 1567..1813 FT /note="lymphotoxin intron C" FT exon 1814..>2226 FT /number=4 FT /note="lymphotoxin" FT prim_transcript 4095..6859 FT /note="TNF mRNA and introns" FT exon <4275..4460 FT /number=1 FT /note="tumor necrosis factor" FT /gene="TNFA" FT /map="6p21.3" FT CDS join(4275..4460,5067..5112,5300..5347,5649..6070) FT /note="tumor necrosis factor" FT /codon_start=1 FT intron 4461..5066 FT /note="TNF intron A" FT exon 5067..5112 FT intron 5113..5299 FT /note="TNF intron B" FT exon 5300..5347 FT /number=3 FT intron 5348..5648 FT /note="TNF intron C" FT source 1..7112 FT /organism="Homo sapiens" XX SQ SEQUENCE 7112 bp; 1676 a; 2005 c; 1865 g; 1566 t; gaattctcga aacttccttt gtagaaaact ttggaaggtg tctgccacat tgatcctgga 60 atgtgtgttt atttggggtt atataaatct gttctgtgga agccacctga agtcaggaag 120 agatggaggg catccttcag gagtgagatg agacctcatc atacttgact gtccagcatc 180 atctctgagt gaggggacca aaaaatttat cttccaaact aggacacttt caagagtgga 240 agggggatcc attaatattt tcacctggac aagaggcaaa caccagaatg tccccgatga 300 aggggatata taatggacct tcttgatgtg aaacctgcca gatgggctgg aaagtccgta 360 tactgggaca agtatgattt gagttgtttg ggacaaggac aggggtacaa gagaaggaaa 420 tgggcaaaga gagaagcctg tactcagcca agggtgcaga gatgttatat atgattgctc 480 ttcagggaac cgggcctcca gctcacaccc cagctgctca accacctcct ctctgaattg 540 actgtccctt ctttggaact ctaggcctga ccccactccc tggccctccc agcccacgat 600 tcccctgacc cgactccctt tcccagaact cagtcgcctg aacccccagc ctgtggttct 660 ctcctaggcc tcagcctttc ctgcctttga ctgaaacagc agtatcttct aagccctggg 720 ggcttccccg ggccccagcc ccgacctaga acccgcccgc tgcctgccac gctgccactg 780 ccgcttcctc tataaaggga cctgagcgtc cgggcccagg ggctccgcac agcaggtgag 840 gctctcctgc cccatctcct tgggctgccc gtgcttcgtg ctttggacta ccgcccagca 900 gtgtcctgcc ctctgcctgg gcctcggtcc ctcctgcacc tgctgcctgg atccccggcc 960 tgcctgggcc tgggccttgg tgggtttggt tttggtttcc ttctctgtct ctgactctcc 1020 atctgtcagt ctcattgtct ctgtcacaca ttctctgttt ctgccatgat tcctctctgt 1080 tcccttcctg tctctctctg tctccctctg ctcaccttgg ggtttctctg actgcatctt 1140 gtccccttct ctgtcgatct ctctctcggg ggtcgggggg tgctgtctcc cagggcggga 1200 ggtctgtctt ccgccgcgtg ccccgccccg ctcactgtct ctctctctct ctctctttct 1260 ctgcaggttc tccccatgac accacctgaa cgtctcttcc tcccaagggt gtgtggcacc 1320 accctacacc tcctccttct ggggctgctg ctggttctgc tgcctggggc ccaggtgagg 1380 cagcaggaga atgggggctg ctggggtggc tcagccaaac cttgagccct agagcccccc 1440 tcaactctgt tctcccctag gggctccctg gtgttggcct cacaccttca gctgcccaga 1500 ctgcccgtca gcaccccaag atgcatcttg cccacagcac cctcaaacct gctgctcacc 1560 tcattggtaa acatccacct gacctcccag acatgtcccc accagctctc ctcctacccc 1620 tgcctcagga acccaagcat ccacccctct cccccaactt cccccacgct aaaaaaaaca 1680 gagggagccc actcctatgc ctccccctgc catcccccag gaactcagtt gttcagtgcc 1740 cacttcctca gggattgaga cctctgatcc agacccctga tctcccaccc ccatccccta 1800 tggctcttcc taggagaccc cagcaagcag aactcactgc tctggagagc aaacacggac 1860 cgtgccttcc tccaggatgg tttctccttg agcaacaatt ctctcctggt ccccaccagt 1920 ggcatctact tcgtctactc ccaggtggtc ttctctggga aagcctactc tcccaaggcc 1980 acctcctccc cactctacct ggcccatgag gtccagctct tctcctccca gtaccccttc 2040 catgtgcctc tcctcagctc ccagaagatg gtgtatccag ggctgcagga accctggctg 2100 cactcgatgt accacggggc tgcgttccag ctcacccagg gagaccagct atccacccac 2160 acagatggca tcccccacct agtcctcagc cctagtactg tcttctttgg agccttcgct 2220 ctgtagaact tggaaaaatc cagaaagaaa aaataattga tttcaagacc ttctccccat 2280 tctgcctcca ttctgaccat ttcaggggtc gtcaccacct ctcctttggc cattccaaca 2340 gctcaagtct tccctgatca agtcaccgga gctttcaaag aaggaattct aggcatccca 2400 ggggaccaca cctccctgaa ccatccctga tgtctgtctg gctgaggatt tcaagcctgc 2460 ctaggaattc ccagcccaaa gctgttggtc ttgtccacca gctaggtggg gcctagatcc 2520 acacacagag gaagagcagg cacatggagg agcttggggg atgactagag gcagggaggg 2580 gactatttat gaaggcaaaa aaattaaatt atttatttat ggaggatgga gagaggggaa 2640 taatagaaga acatccaagg agaaacagag acaggcccaa gagatgaaga gtgagagggc 2700 atgcgcacaa ggctgaccaa gagagaaaga agtaggcatg agggatcaca gggccccaga 2760 aggcagggaa aggctctgaa agccagctgc cgaccagagc cccacacgga ggcatctgca 2820 ccctcgatga agcccaataa acctcttttc tctgaaatgc tgtctgcttg tgtgtgtgtg 2880 tctgggagtg agaacttccc agtctatcta aggaatggag ggagggacag agggctcaaa 2940 gggagcaaga gctgtgggga gaacaaaagg ataagggctc agagagcttc agggatatgt 3000 gatggactca ccaggtgagg ccgccagact gctgcagggg aagcaaagga gaagctgaga 3060 agatgaagga aaagtcaggg tctggagggg cgggggtcag ggagctcctg ggagatatgg 3120 ccacatgtag cggctctgag gaatgggtta caggagacct ctggggagat gtgaccacag 3180 caatgggtag gagaatgtcc agggctatga aagtcgagta tggggacccc cccttaacga 3240 agacagggcc atgtagaggg ccccagggag tgaaagagcc tccaggacct ccaggtatgg 3300 aatacagggg acgtttaaga agatatggcc acacactggg gccctgagaa gtgagagctt 3360 catgaaaaaa atcagggacc ccagagttcc ttggaagcca agactgaaac cagcattatg 3420 agtctccggg tcagaatgaa agaagagggc ctgccccagt ggggtctgtg aattcccggg 3480 ggtgatttca ctccccgggg ctgtcccagg cttgtccctg ctacccgcac ccagcctttc 3540 ctgaggcctc aagcctgcca ccaagccccc agctccttct ccccgcaggg cccaaacaca 3600 ggcctcagga ctcaacacag cttttccctc caaccccgtt ttctctccct caacggactc 3660 agctttctga agcccctccc agttctagtt ctatcttttt cctgcatcct gtctggaagt 3720 tagaaggaaa cagaccacag acctggtccc caaaagaaat ggaggcaata ggttttgagg 3780 ggcatgggga cggggttcag cctccagggt cctacacaca aatcagtcag tggcccagaa 3840 gacccccctc ggaatcggag cagggaggat ggggagtgtg aggggtatcc ttgatgcttg 3900 tgtgtcccca actttccaaa tccccgcccc cgcgatggag aagaaaccga gacagaaggt 3960 gcagggccca ctaccgcttc ctccagatga gctcatgggt ttctccacca aggaagtttt 4020 ccgctggttg aatgattctt tccccgccct cctctcgccc cagggacata taaaggcagt 4080 tgttggcaca cccagccagc agacgctccc tcagcaagga cagcagagga ccagctaaga 4140 gggagagaag caactacaga ccccccctga aaacaaccct cagacgccac atcccctgac 4200 aagctgccag gcaggttctc ttcctctcac atactgaccc acggcttcac cctctctccc 4260 ctggaaagga caccatgagc actgaaagca tgatccggga cgtggagctg gccgaggagg 4320 cgctccccaa gaagacaggg gggccccagg gctccaggcg gtgcttgttc ctcagcctct 4380 tctccttcct gatcgtggca ggcgccacca cgctcttctg cctgctgcac tttggagtga 4440 tcggccccca gagggaagag gtgagtgcct ggccagcctt catccactct cccacccaag 4500 gggaaatgga gacgcaagag agggagagag atgggatggg tgaaagatgt gcgctgatag 4560 ggagggatgg agagaaaaaa acgtggagaa agacggggat gcagaaagag atgtggcaag 4620 agatggggaa gagagagaga gaaagatgga gagacaggat gtctggcaca tggaaggtgc 4680 tcactaagtg tgtatggagt gaatgaatga atgaatgaat gaacaagcag atatataaat 4740 aagatatgga gacagatgtg gggtgtgaga agagagatgg gggaagaaac aagtgatatg 4800 aataaagatg gtgagacaga aagagcggga aatatgacag ctaaggagag agatggggga 4860 gataaggaga gaagaagata gggtgtctgg cacacagaag acactcaggg aaagagctgt 4920 tgaatgcctg gaaggtgaat acacagatga atggagagag aaaaccagac acctcagggc 4980 taagagcgca ggccagacag gcagccagct gttcctcctt taagggtgac tccctcgatg 5040 ttaaccattc tccttctccc caacagttcc ccagggacct ctctctaatc agccctctgg 5100 cccaggcagt cagtaagtgt ctccaaacct ctttcctaat tctgggtttg ggtttggggg 5160 tagggttagt accggtatgg aagcagtggg ggaaatttaa agttttggtc ttgggggagg 5220 atggatggag gtgaaagtag gggggtattt tctaggaagt ttaagggtct cagctttttc 5280 ttttctctct cctcttcagg atcatcttct cgaaccccga gtgacaagcc tgtagcccat 5340 gttgtaggta agagctctga ggatgtgtct tggaacttgg agggctagga tttggggatt 5400 gaagcccggc tgatggtagg cagaacttgg agacaatgtg agaaggactc gctgagctca 5460 agggaagggt ggaggaacag cacaggcctt agtgggatac tcagaacgtc atggccaggt 5520 gggatgtggg atgacagaca gagaggacag gaaccggatg tggggtgggc agagctcgag 5580 ggccaggatg tggagagtga accgacatgg ccacactgac tctcctctcc ctctctccct 5640 ccctccagca aaccctcaag ctgaggggca gctccagtgg ctgaaccgcc gggccaatgc 5700 cctcctggcc aatggcgtgg agctgagaga taaccagctg gtggtgccat cagagggcct 5760 gtacctcatc tactcccagg tcctcttcaa gggccaaggc tgcccctcca cccatgtgct 5820 cctcacccac accatcagcc gcatcgccgt ctcctaccag accaaggtca acctcctctc 5880 tgccatcaag agcccctgcc agagggagac cccagagggg gctgaggcca agccctggta 5940 tgagcccatc tatctgggag gggtcttcca gctggagaag ggtgaccgac tcagcgctga 6000 gatcaatcgg cccgactatc tcgactttgc cgagtctggg caggtctact ttgggatcat 6060 tgccctgtga ggaggacgaa catccaacct tcccaaacgc ctcccctgcc ccaatccctt 6120 tattaccccc tccttcagac accctcaacc tcttctggct caaaaagaga attgggggct 6180 tagggtcgga acccaagctt agaactttaa gcaacaagac caccacttcg aaacctggga 6240 ttcaggaatg tgtggcctgc acagtgaagt gctggcaacc actaagaatt caaactgggg 6300 cctccagaac tcactggggc ctacagcttt gatccctgac atctggaatc tggagaccag 6360 ggagcctttg gttctggcca gaatgctgca ggacttgaga agacctcacc tagaaattga 6420 cacaagtgga ccttaggcct tcctctctcc agatgtttcc agacttcctt gagacacgga 6480 gcccagccct ccccatggag ccagctccct ctatttatgt ttgcacttgt gattatttat 6540 tatttattta ttatttattt atttacagat gaatgtattt atttgggaga ccggggtatc 6600 ctgggggacc caatgtagga gctgccttgg ctcagacatg ttttccgtga aaacggagct 6660 gaacaatagg ctgttcccat gtagccccct ggcctctgtg ccttcttttg attatgtttt 6720 ttaaaatatt tatctgatta agttgtctaa acaatgctga tttggtgacc aactgtcact 6780 cattgctgag cctctgctcc ccaggggagt tgtgtctgta atcgccctac tattcagtgg 6840 cgagaaataa agtttgctta gaaaagaaac atggtctcct tcttggaatt aattctgcat 6900 ctgcctcttc ttgtgggtgg gaagaagctc cctaagtcct ctctccacag gctttaagat 6960 ccctcggacc cagtcccatc cttagactcc tagggccctg gagaccctac ataaacaaag 7020 cccaacagaa tattccccat cccccaggaa acaagagcct gaacctaatt acctctccct 7080 cagggcatgg gaatttccaa ctctgggaat tc 7112 //