ID HSEGFPRE standard; RNA; PRI; 5532 BP. XX AC X00588; XX DT 13-JUN-1985 (Rel. 06, Created) DT 06-JUL-1989 (Rel. 20, Last updated, Version 1) XX DE Human mRNA for precursor of epidermal growth factor receptor XX KW epidermal growth factor receptor; signal peptide. XX OS Homo sapiens (human) OC Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; OC Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. XX RN [1] RP 1-5532 RL Ullrich A., Coussens L., Hayflick J.S., Dull T.J., Gray A., RL Tam A.W., Lee J., Yarden Y., Libermann T.A., Schlessinger J., RL Downward J., Mayes E.L., Whittle N., Waterfield M.D., Seeburg P.H.; RL "Human epidermal growth factor receptor cDNA sequence and aberrant RL expression of the amplified gene in A431 epidermoid carcinoma RL cells"; RL Nature 309:418-425(1984). XX DR SWISS-PROT; P00533; EGFR_HUMAN. XX FH Key Location/Qualifiers FH FT source 1..5532 FT /organism="Homo sapiens" FT CDS 187..258 FT /note="put. signal peptide" FT CDS 259..2127 FT /note="EGF extracellular domain" FT misc_feature 568..576 FT /note="Asn-linked glycosylation site" FT misc_feature 709..717 FT /note="Asn-linked glycosylation site" FT misc_feature 772..780 FT /note="Asn-linked glycosylation site" FT misc_feature 997..1006 FT /note="Asn-linked glycosylation site" FT misc_feature 1267..1275 FT /note="Asn-linked glycosylation site" FT misc_feature 1290..1298 FT /note="Asn-linked glycosylation site" FT misc_feature 1423..1431 FT /note="Asn-linked glycosylation site" FT misc_feature 1506..1514 FT /note="Asn-linked glycosylation site" FT misc_feature 1718..1726 FT /note="Asn-linked glycosylation site" FT misc_feature 1838..1846 FT /note="Asn-linked glycosylation site" FT misc_feature 1924..3732 FT /note="v-erb B homology" FT misc_feature 1993..2001 FT /note="Asn-linked glycosylation site" FT misc_feature 2053..2061 FT /note="Asn-linked glycosylation site" FT CDS 2128..2190 FT /note="EGF transmembrane region" FT CDS 2191..3816 FT /note="EGF cytoplasmatic domain" FT misc_feature 3313..3321 FT /note="Asn-linked glycosylation site" FT misc_feature 3316..3324 FT /note="Asn-linked glycosylation site" FT misc_feature 3466..3474 FT /note="Asn-linked glycosylation site" FT misc_feature 3628..3636 FT /note="Asn-linked glycosylation site" FT misc_feature 5512..5517 FT /note="polyadenylation signal" FT polyA_site 5532..5532 FT /note="polyadenylation site" XX SQ Sequence 5532 BP; 1472 A; 1484 C; 1337 G; 1239 T; 0 other; gccgcgctgc gccggagtcc cgagctagcc ccggcgccgc cgccgcccag accggacgac 60 aggccacctc gtcggcgtcc gcccgagtcc ccgcctcgcc gccaacgcca caaccaccgc 120 gcacggcccc ctgactccgt ccagtattga tcgggagagc cggagcgagc tcttcgggga 180 gcagcgatgc gaccctccgg gacggccggg gcagcgctcc tggcgctgct ggctgcgctc 240 tgcccggcga gtcgggctct ggaggaaaag aaagtttgcc aaggcacgag taacaagctc 300 acgcagttgg gcacttttga agatcatttt ctcagcctcc agaggatgtt caataactgt 360 gaggtggtcc ttgggaattt ggaaattacc tatgtgcaga ggaattatga tctttccttc 420 ttaaagacca tccaggaggt ggctggttat gtcctcattg ccctcaacac agtggagcga 480 attcctttgg aaaacctgca gatcatcaga ggaaatatgt actacgaaaa ttcctatgcc 540 ttagcagtct tatctaacta tgatgcaaat aaaaccggac tgaaggagct gcccatgaga 600 aatttacagg aaatcctgca tggcgccgtg cggttcagca acaaccctgc cctgtgcaac 660 gtggagagca tccagtggcg ggacatagtc agcagtgact ttctcagcaa catgtcgatg 720 gacttccaga accacctggg cagctgccaa aagtgtgatc caagctgtcc caatgggagc 780 tgctggggtg caggagagga gaactgccag aaactgacca aaatcatctg tgcccagcag 840 tgctccgggc gctgccgtgg caagtccccc agtgactgct gccacaacca gtgtgctgca 900 ggctgcacag gcccccggga gagcgactgc ctggtctgcc gcaaattccg agacgaagcc 960 acgtgcaagg acacctgccc cccactcatg ctctacaacc ccaccacgta ccagatggat 1020 gtgaaccccg agggcaaata cagctttggt gccacctgcg tgaagaagtg tccccgtaat 1080 tatgtggtga cagatcacgg ctcgtgcgtc cgagcctgtg gggccgacag ctatgagatg 1140 gaggaagacg gcgtccgcaa gtgtaagaag tgcgaagggc cttgccgcaa agtgtgtaac 1200 ggaataggta ttggtgaatt taaagactca ctctccataa atgctacgaa tattaaacac 1260 ttcaaaaact gcacctccat cagtggcgat ctccacatcc tgccggtggc atttaggggt 1320 gactccttca cacatactcc tcctctggat ccacaggaac tggatattct gaaaaccgta 1380 aaggaaatca cagggttttt gctgattcag gcttggcctg aaaacaggac ggacctccat 1440 gcctttgaga acctagaaat catacgcggc aggaccaagc aacatggtca gttttctctt 1500 gcagtcgtca gcctgaacat aacatccttg ggattacgct ccctcaagga gataagtgat 1560 ggagatgtga taatttcagg aaacaaaaat ttgtgctatg caaatacaat aaactggaaa 1620 aaactgtttg ggacctccgg tcagaaaacc aaaattataa gcaacagagg tgaaaacagc 1680 tgcaaggcca caggccaggt ctgccatgcc ttgtgctccc ccgagggctg ctggggcccg 1740 gagcccaggg actgcgtctc ttgccggaat gtcagccgag gcagggaatg cgtggacaag 1800 tgcaagcttc tggagggtga gccaagggag tttgtggaga actctgagtg catacagtgc 1860 cacccagagt gcctgcctca ggccatgaac atcacctgca caggacgggg accagacaac 1920 tgtatccagt gtgcccacta cattgacggc ccccactgcg tcaagacctg cccggcagga 1980 gtcatgggag aaaacaacac cctggtctgg aagtacgcag acgccggcca tgtgtgccac 2040 ctgtgccatc caaactgcac ctacggatgc actgggccag gtcttgaagg ctgtccaacg 2100 aatgggccta agatcccgtc catcgccact gggatggtgg gggccctcct cttgctgctg 2160 gtggtggccc tggggatcgg cctcttcatg cgaaggcgcc acatcgttcg gaagcgcacg 2220 ctgcggaggc tgctgcagga gagggagctt gtggagcctc ttacacccag tggagaagct 2280 cccaaccaag ctctcttgag gatcttgaag gaaactgaat tcaaaaagat caaagtgctg 2340 ggctccggtg cgttcggcac ggtgtataag ggactctgga tcccagaagg tgagaaagtt 2400 aaaattcccg tcgctatcaa ggaattaaga gaagcaacat ctccgaaagc caacaaggaa 2460 atcctcgatg aagcctacgt gatggccagc gtggacaacc cccacgtgtg ccgcctgctg 2520 ggcatctgcc tcacctccac cgtgcaactc atcacgcagc tcatgccctt cggctgcctc 2580 ctggactatg tccgggaaca caaagacaat attggctccc agtacctgct caactggtgt 2640 gtgcagatcg caaagggcat gaactacttg gaggaccgtc gcttggtgca ccgcgacctg 2700 gcagccagga acgtactggt gaaaacaccg cagcatgtca agatcacaga ttttgggctg 2760 gccaaactgc tgggtgcgga agagaaagaa taccatgcag aaggaggcaa agtgcctatc 2820 aagtggatgg cattggaatc aattttacac agaatctata cccaccagag tgatgtctgg 2880 agctacgggg tgaccgtttg ggagttgatg acctttggat ccaagccata tgacggaatc 2940 cctgccagcg agatctcctc catcctggag aaaggagaac gcctccctca gccacccata 3000 tgtaccatcg atgtctacat gatcatggtc aagtgctgga tgatagacgc agatagtcgc 3060 ccaaagttcc gtgagttgat catcgaattc tccaaaatgg cccgagaccc ccagcgctac 3120 cttgtcattc agggggatga aagaatgcat ttgccaagtc ctacagactc caacttctac 3180 cgtgccctga tggatgaaga agacatggac gacgtggtgg atgccgacga gtacctcatc 3240 ccacagcagg gcttcttcag cagcccctcc acgtcacgga ctcccctcct gagctctctg 3300 agtgcaacca gcaacaattc caccgtggct tgcattgata gaaatgggct gcaaagctgt 3360 cccatcaagg aagacagctt cttgcagcga tacagctcag accccacagg cgccttgact 3420 gaggacagca tagacgacac cttcctccca gtgcctgaat acataaacca gtccgttccc 3480 aaaaggcccg ctggctctgt gcagaatcct gtctatcaca atcagcctct gaaccccgcg 3540 cccagcagag acccacacta ccaggacccc cacagcactg cagtgggcaa ccccgagtat 3600 ctcaacactg tccagcccac ctgtgtcaac agcacattcg acagccctgc ccactgggcc 3660 cagaaaggca gccaccaaat tagcctggac aaccctgact accagcagga cttctttccc 3720 aaggaagcca agccaaatgg catctttaag ggctccacag ctgaaaatgc agaataccta 3780 agggtcgcgc cacaaagcag tgaatttatt ggagcatgac cacggaggat agtatgagcc 3840 ctaaaaatcc agactctttc gatacccagg accaagccac agcaggtcct ccatcccaac 3900 agccatgccc gcattagctc ttagacccac agactggttt tgcaacgttt acaccgacta 3960 gccaggaagt acttccacct cgggcacatt ttgggaagtt gcattccttt gtcttcaaac 4020 tgtgaagcat ttacagaaac gcatccagca agaatattgt ccctttgagc agaaatttat 4080 ctttcaaaga ggtatatttg aaaaaaaaaa aaaaagtata tgtgaggatt tttattgatt 4140 ggggatcttg gagtttttca ttgtcgctat tgatttttac ttcaatgggc tcttccaaca 4200 aggaagaagc ttgctggtag cacttgctac cctgagttca tccaggccca actgtgagca 4260 aggagcacaa gccacaagtc ttccagagga tgcttgattc cagtggttct gcttcaaggc 4320 ttccactgca aaacactaaa gatccaagaa ggccttcatg gccccagcag gccggatcgg 4380 tactgtatca agtcatggca ggtacagtag gataagccac tctgtccctt cctgggcaaa 4440 gaagaaacgg aggggatgaa ttcttcctta gacttacttt tgtaaaaatg tccccacggt 4500 acttactccc cactgatgga ccagtggttt ccagtcatga gcgttagact gacttgtttg 4560 tcttccattc cattgttttg aaactcagta tgccgcccct gtcttgctgt catgaaatca 4620 gcaagagagg atgacacatc aaataataac tcggattcca gcccacattg gattcatcag 4680 catttggacc aatagcccac agctgagaat gtggaatacc taaggataac accgcttttg 4740 ttctcgcaaa aacgtatctc ctaatttgag gctcagatga aatgcatcag gtcctttggg 4800 gcatagatca gaagactaca aaaatgaagc tgctctgaaa tctcctttag ccatcacccc 4860 aaccccccaa aattagtttg tgttacttat ggaagatagt tttctccttt tacttcactt 4920 caaaagcttt ttactcaaag agtatatgtt ccctccaggt cagctgcccc caaaccccct 4980 ccttacgctt tgtcacacaa aaagtgtctc tgccttgagt catctattca agcacttaca 5040 gctctggcca caacagggca ttttacaggt gcgaatgaca gtagcattat gagtagtgtg 5100 aattcaggta gtaaatatga aactagggtt tgaaattgat aatgctttca caacatttgc 5160 agatgtttta gaaggaaaaa agttccttcc taaaataatt tctctacaat tggaagattg 5220 gaagattcag ctagttagga gcccattttt tcctaatctg tgtgtgccct gtaacctgac 5280 tggttaacag cagtcctttg taaacagtgt tttaaactct cctagtcaat atccacccca 5340 tccaatttat caaggaagaa atggttcaga aaatattttc agcctacagt tatgttcagt 5400 cacacacaca tacaaaatgt tccttttgct tttaaagtaa tttttgactc ccagatcagt 5460 cagagcccct acagcattgt taagaaagta tttgattttt gtctcaatga aaataaaact 5520 atattcattt cc 5532