ID   BPV4    STANDARD;  ds-DNA; VRL; 7261 bp.
XX
DE   Bovine papillomavirus type 4 (BPV-4), complete genome.
XX
AC   D00146
XX
DT   15-JUN-1989
XX
OS   BPV-4 DNA originally cloned in pAT153, separated from the plasmid
OS   vector by digestion with BamHI, recircularized by ligation.
OC   Bovine papillomavirus type 4 
OC   Viridae; ds-DNA nonenveloped viruses; Papovaviridae;
OC   Papillomavirus.
XX
RN   [1]
RP   1-7261
RA   Patel,K.R., Smith,K.T. and Campo,S.;
RT   "The Nucleotide Sequence and Genome Organization of Bovine
RT   Papillomavirus Type 4";
RL   J. Gen. Virol. 68, 2117-2128 (1987).
XX
XX   Open reading frames (ORFs) have been identified both on the basis
XX   of amino acid comparison with other papillomaviruses and on their
XX   transcriptional pattern.  Eight early ORFs (E1 to 8) were
XX   recognized, coding for DNA replication and cell transformation
XX   functions, and three late ORFs (L1 to 3), coding for structural
XX   proteins. Like the E5 ORF of human papillomavirus type 6, the E5
XX   ORF of BPV-4 is discontinuous.  Comparison between the polypeptides
XX   of BPV-4 and other papillomaviruses showed that BPV-4 is
XX   evolutionary closer to the epitheliotropic human and rabbit viruses
XX   than to BPV-1.  corresponds to DDBJ (rel3.0) entry <BPV4>(D00146)
XX   dated entered
XX
FT   KEY              Location/Qualifiers
FT    protein_bind    1..10
FT                    /bound_moiety="Sp-1"
FT                    /note="putative"
FT    enhancer        22..52
FT                    /note="putative"
FT    promoter        86..89
FT                    /note="putative"
FT    protein_bind    96..107
FT                    /bound_moiety="NF-1"
FT                    /note="putative"
FT    TATA_signal     115..119
FT                    /note="putative"
FT    protein_bind    142..154
FT                    /bound_moiety="NF-1"
FT                    /note="putative"
FT    protein_bind    176..189
FT                    /bound_moiety="E2 protein"
FT                    /note="putative"
FT    misc_feature    202..210
FT                    /standard_name="Splice donor site"
FT                    /note="putative"
FT    promoter        213..223
FT                    /note="putative"
FT    protein_bind    268..281
FT                    /bound_moiety="E2 binding"
FT                    /note="putative"
FT    CDS             333..491
FT                    /note="E8 orf from bp 237 to 491"
FT                    /gene="E8"
FT                    /note="putative"
FT                    /codon_start=1
FT    CDS             715..1014
FT                    /note="E6 orf from 646 to 1014"
FT                    /gene="E6"
FT                    /note="putative"
FT                    /codon_start=1
FT    misc_feature    1014..1022
FT                    /standard_name="Splice donor site"
FT                    /note="putative"
FT    CDS             <1074..1304
FT                    /note="E7 ORF from 1074 to 1304"
FT                    /gene="E7"
FT                    /note="putative"
FT                    /codon_start=1
FT    CAAT_signal     1242..1245
FT                    /note="putative"
FT    protein_bind    1276..1289
FT                    /bound_moiety="NF-1"
FT                    /note="putative"
FT    TATA_signal     1316..1320
FT                    /note="putative"
FT    misc_feature    1348..1356
FT                    /standard_name="Splice donor site"
FT                    /note="putative"
FT    misc_feature    1543..1553
FT                    /standard_name="Splice acceptor site"
FT                    /note="putative"
FT    CDS             1564..2781
FT                    /note="E1 orf from 1549 to 2781"
FT                    /product="replication protein"
FT                    /gene="E1"
FT                    /note="putative"
FT                    /codon_start=1
FT    misc_feature    1777..1785
FT                    /standard_name="Splice donor site"
FT                    /note="putative"
FT    misc_feature    2186..2194
FT                    /standard_name="Splice donor site"
FT                    /note="putative"
FT    CDS             2775..3071
FT                    /note="E3 orf from bp 2763 to 3071"
FT                    /gene="E3"
FT                    /codon_start=1
FT    misc_feature    2920..2928
FT                    /standard_name="Splice donor site"
FT                    /note="putative"
FT    misc_feature    2930..2938
FT                    /standard_name="Splice donor site"
FT                    /note="putative"
FT    CDS             2996..4000
FT                    /note="E2 orf from 2927 to 4000"
FT                    /product="regulatory protein"
FT                    /gene="E2"
FT                    /note="putative"
FT                    /codon_start=1
FT    CDS             3300..3446
FT                    /note="E5a orf from 3288 to 3446"
FT                    /gene="E5a"
FT                    /note="putative"
FT                    /codon_start=1
FT    CDS             <3346..3669
FT                    /note="E4 ORF from bp 3346 to 3669"
FT                    /gene="E4"
FT                    /note="putative"
FT                    /codon_start=1
FT    misc_feature    3354..3376
FT                    /standard_name="Splice acceptor site"
FT                    /note="putative"
FT    CDS             <3447..3734
FT                    /note="E5b ORF from bp 3447 to 3734"
FT                    /gene="E5b"
FT                    /note="putative"
FT                    /codon_start=1
FT    misc_feature    3768..3776
FT                    /standard_name="Splice donor site"
FT                    /note="putative"
FT    misc_feature    3960..3968
FT                    /standard_name="Splice donor site"
FT                    /note="putative"
FT    polyA_signal    4009..4014
FT                    /note="putative"
FT    CDS             4015..5088
FT                    /note="L2 orf from 3991 to 5088"
FT                    /product="minor capsid protein"
FT                    /gene="L2"
FT                    /note="putative"
FT                    /codon_start=1
FT    misc_feature    4018..4028
FT                    /standard_name="Splice acceptor site"
FT                    /note="putative"
FT    enhancer        4217..4226
FT                    /note="putative"
FT    enhancer        4519..4525
FT                    /note="putative"
FT    misc_feature    5031..5039
FT                    /standard_name="Splice donor site"
FT                    /note="putative"
FT    misc_feature    5223..5231
FT                    /standard_name="Splice donor site"
FT                    /note="putative"
FT    CAAT_signal     5466..5469
FT                    /note="putative"
FT    protein_bind    5481..5490
FT                    /bound_moiety="Sp-1"
FT                    /note="putative"
FT    TATA_signal     5491..5495
FT                    /note="putative"
FT    misc_feature    5523..5542
FT                    /standard_name="Splice acceptor site"
FT                    /note="putative"
FT    misc_feature    5585..5595
FT                    /standard_name="Splice acceptor site"
FT                    /note="putative"
FT    CDS             5595..7115
FT                    /note="L1 orf from 5550 to 7115"
FT                    /product="major capsid protein"
FT                    /gene="L1"
FT                    /note="putative"
FT                    /codon_start=1
FT    CDS             6388..6729
FT                    /note="L3 orf from 6385 to 6729"
FT                    /gene="L3"
FT                    /note="putative"
FT                    /codon_start=1
FT    misc_feature    6906..6914
FT                    /standard_name="Splice donor site"
FT                    /note="putative"
FT    protein_bind    7046..7058
FT                    /bound_moiety="E2 protein"
FT                    /note="putative"
FT    polyA_signal    7151..7156
FT                    /note="putative"
FT    polyA_signal    7187..7192
FT                    /note="putative"
FT    source          1..7261
FT                    /organism="Bovine papillomavirus type 4"
XX
SQ   SEQUENCE  7261 bp;  2246  a;  1404  c;  1639  g;  1972  t;
     acccgccttg cacctgggac gctgtgtaaa gcaaaaacta tgcaggcaca cctaaaggct          60
     gtcaactttg aagttttatt ggccacaaaa ttaattggcc gagccaagtt ggcatataaa         120
     actgttcttg aatagtcaca ctggcttttg gccataacaa gctcagacaa agtgtaccga         180
     ttgcggtcga aactctcacg ctaggtaagt gttgtaccta acaactattt acctagggaa         240
     aatatcagtt gcatcccatt cggtcgtacc gaatcgggtg catatataag gagagcagtg         300
     cggatttggt gcatgaggca gtagctctca tcatgtcttt gtggcttatc tatgttttgt         360
     tgcttttctg gtgtgctttt aatttctgca ctgttatttg caattattgt gtaccttctg         420
     ttaatttcta ctattactcg gttagatgga tgggattgaa tttttattta ttgtgtttat         480
     tatttgcttg atttcctgat ttgcttttgc tatatatagt ggagattatg cgtttggtgt         540
     tattgctgtc tttgctagat gaattagaac aggaggaaca gtaaatagaa tattgctgtg         600
     cttttacatt tgagaaggat tgtagtgtgg gcatttaaaa gctgaccttc cagtcttaat         660
     tgcagtaggc gcctaagagg gtggtggtgg tataagttca agtttttcaa gaaaatgaag         720
     gggcagaacg tgacattaca ggacattgca atagaattag aggatacaat tagtccaatt         780
     aacttgcatt gtgaagagga gattgaaact gaggaggtgg acacccctaa cccttttgca         840
     ataacagcaa cttgttatgc ttgcgagcaa gtccttcgtt tagctgttgt aacgtcaaca         900
     gaagaattca tctcaactgc agcaactgct gttcgacaac ctctttctat ctgtgtgcag         960
     cttgcttcca aacaagtgtt ctgtaaccgc agacccgagc gaaatggacc ctaaaggtac        1020
     taccgtgctt gactttattg aggaacaagc acagaatgta gtcaatctga tagcgagcca        1080
     aggcagtgaa gaaaattgtt ctgatatctg acctaattga taatgctgaa tacgagcaag        1140
     ggaattctgc agaattgttt gcacaacagc aggctttcga tttccataaa gacatatgca        1200
     ccacaaagcg aaacttaaaa cggtcactgc gaaagccttt tcaatgcata accagtcaga        1260
     gtaacaccct gcttctagat ccgcgccaaa aagacgtttg ctagacgaca gtggttataa        1320
     tgaagatatt ttctacagaa gtggctacag gtagatgaaa tggcggctca gagggttacg        1380
     ggagcttaac ctcgcaacat ttgtctggtg tatgcctaaa tcaaggggat aacggagggg        1440
     tagataaaga aaatgtagat tgcacagcgc tactgcgagc cggtagtcgc agggcagcgt        1500
     atttgggtgt ttttaaagag aaatttacta ttagcttcac tgctttgaca agaatcttta        1560
     aaaatgacaa aacattgctg cagaaactgg gtgggaactg tatatagagc cagagaagaa        1620
     ttgctcgagg cttcaaaaac aattttgcaa aaatgctgtg attttattct attgttaacg        1680
     cacacttgta aatatggttt cctggcattg tttttgctgg aatttaagac tgctaaaagt        1740
     agagagactg tgcagcgctt gtttgagcat atattgcagg tggaaaaaga agatatgctg        1800
     ttagaacctc ctaagttaaa aagtttaccc gcggcaacct tttggtggaa aattcagcat        1860
     agcaacaact cttttaaatg gggaactcta cctgattgga tagctagaca aactatgata        1920
     tctcatcaaa tagcagatga tgagccattt agtctcagtg taatggtgca gtgggcttat        1980
     gatcataatt atactgaaga atcaacaatt gcatatcatt atgcaaaatt agcctcagaa        2040
     gattcaaatg ctgcagcatt tctaaaatgt aataatcaag taaagcatgt gaaagaatgt        2100
     gcacaaatga ctaggtatta taagactgca gaaatgacag aaatgtcaat gggacaatgg        2160
     attaaaaaat gcattggtga gatagaaggt gtaggtgatt ggaagcaaat ctgcaaattt        2220
     ttaaagtttc aaaatgtcaa ctttttatca tttatgtctg ctttaaaaga tttgttgcac        2280
     agagtaccca aaaggaattg catggttatc tgtgggcctc caaacacagg aaaatctatg        2340
     tttgtaatga gttttatgaa agctttgcaa ggaaaagtat tatcatttgt aaattcaaaa        2400
     agccattttt ggctccagcc tttacgtgga gcaaaagtag ctgtattaga tgatgctaca        2460
     cgagccacat ggacatactt tgatacctac ctcagaaatg gcctagatgg cacgcctgtg        2520
     tcattagata tgaagcatag agcccccttg caaatatgtt tccccccttt ggtaatcacc        2580
     actaatgtca atgtgatgca ggatcctgca tatttttatt tgcacagtag aattgtatgt        2640
     tttgagtttc caaatacatt tccattagat gaggctggaa atcctctttt attaattgat        2700
     gaacttagtt ggaaatcttt ttttgaaagg ctttggacac agctagacct cacagacgct        2760
     gaggagagac gaagatggtg agcctcgaag cccgtttcga tgctgtccaa gatcagttgc        2820
     tacaagttta tgaaaatgac tctaatacat tagaactgtg tttacaatac tgggcactca        2880
     taaggagaga gaatgcactt tattattatg ccaggcaaca aggtaaaaca aggctagttt        2940
     gtacacagtg cctcccacca gagtatcaga acaaaaggct aaggatgcaa tcaagatgta        3000
     cttatgtttg gaaagcctgc agaaatcaga gtttgccaat caaagatggt cacttgtgga        3060
     cactagcata gagacattta aggcgccacc tgaaaacact ttaaaaaaaa ggggccagca        3120
     tgtgactgtc atttatgatc agaatgcaat gaattcaatg gtatacactt tgtggaaaga        3180
     agtgtattat gttgatgaaa ctgagacatg gcataaaacc agtagcgatt tggattatga        3240
     tggaatattt tatattgata atcaggggaa caagatatat tatgtgaact ttcaggacga        3300
     tgcagcattg tattctaatt ctggcatggg gcaagtgcat tttgaaagca aagttctttc        3360
     tccctctgtt accagttcgc ttcgtgttgg gagatccgga ggacaacgcg ggtacccaaa        3420
     ccggggaccc agcccgagga cgatgacgac cgtcccccca tcttccagag acgcccgggg        3480
     ccggcagcag agggcgcagt cgtcttcgcg atcgcgatca cggtcacgat cacgatcgcc        3540
     tacgaagggg ccgcactcca gtggacgaga cacgcggcta ccgagtcccg ggagaccccc        3600
     gggaggaaga cgaaggggca cccccgaacg ggaacgatgc cctggaacac cgactccgcc        3660
     aactcctgac caagtgggag gacgatcttc aacgcctaag agacaagctt cgtctagact        3720
     tgctcagctt atagacgcgg catacgaccc tccagtactc ctgctacaag gtgctgcaaa        3780
     cactttaaaa tgctttaggc gcagggcaac gcaggctcat cctcacaaat ttctgtgcat        3840
     gagcacaagc tggacatggg ttagcaaaac ttcccctttg aaatcgggac atagaatgct        3900
     gattgcattt tcgaactctg agcaaaggaa ctgctttttg gcttctgttc gattaccaaa        3960
     aggtgtcagt gctgtgaaag gggctcttga cgggttatag caaatgctat taaaatggtt        4020
     cgtgcagcaa gacgaaaacg tgcgtctgag gatgatttgt acagagggtg cagaatgggg        4080
     caagactgcc ctattgacat caaaaacaaa tatgaacaca acacattagc tgacagaatt        4140
     ttgaagtggg tcagctcttt cttgtacttt ggacaattag gtataagcag tggtaaaggt        4200
     acaggggggt ccacaggcta cacaccattg ggtggcagag gaggaggtgg agtaacctct        4260
     gggaaaggag caaatgttgt tagacccact gttattgtgg atgcattagg tcctactggg        4320
     gttcctattg atcctgcagt cccagatagt agtattgtgc cattattgga aagcagtggg        4380
     ggcagcacca cattagatgc aactcctgga gctgaaattg aaatcattgc agaggtgcac        4440
     ccaccacctg tatatgaagg ccctgaagtt actatagggg acatagaaga gcccccaata        4500
     ttagaagtag tgcctgaaac acatcctaca tctcgtgtta gaagcacaac aagtaaacat        4560
     gacaacccag ctttcacagc atacgttgca agtgcacaat taccaggaga aacctcagct        4620
     tcagacaatg tttacatttt gcatggtttc aatggtgatt tcgtggggca agctgatcct        4680
     gaaggggata caatatttga agagattcct ctggaagaat ttggggttcc tgacatgcca        4740
     ccaagcacta gcacacctac aagctcattc agaagtgttt taaataaatt tcagcgaagg        4800
     ctgtacaata gaaagttagt tcagcaagtc aaaatcacaa acagaaacac ttttttgaag        4860
     caaccgtccc aatttgtgca gtgggaattt gacaaccctg cctatgttga tgactctttg        4920
     tcattaatct ttcagcaaga tttagatgaa gtgtcagctg ctcctgatgc tgattttcag        4980
     gatattgtta agctaagcag accagtattc acaacaaaag aaggcttagt caggttgagc        5040
     agattaggcc aaagaggaac tattaaaaca cgcatggctt gcaaatagtg gccatgtgca        5100
     ttattataca gatttgagtc caattagacc attagaagac attgaaatga cttcctttgg        5160
     gagtgtctgg agaaatgtaa ttatgcagcc attaggtgaa agcacattca ttgatacagt        5220
     gcaaggtcag acaatttaaa tgaagcgtca tagagtactc tgagagtgct ttagaggatg        5280
     ctatggagga ggattttagt caagtgcgtt tgaaataagc acttctgcaa gaagtagaac        5340
     tagtatagtc actgttcaag aaggaatacc accaggatca gtcaaactgt ttataaatga        5400
     tgctgcagca acagttgaca ctggttatct gccaggaaag ccagattatg aggacccttt        5460
     caccccaata gagcctgctg tcccgcctga tataatactc aattttgaag atgacactgc        5520
     aacctttttt ctacatccca gtcttttgaa aaagcataaa cataacaaac attggtttct        5580
     ttaatgtttt acagatgtct ttctgggttc caaattctgc aaagctgtac ttgccaccgc        5640
     ctacacctgt cacacaattt cttgacacgg atgagtttgt cacacgcact gacatctttt        5700
     accacacaag cacagaccga ctgctgtttg taggccatcc atattttcga cctaaaaaaa        5760
     ggagacaccg ttgttgttcc caaatgtccg gcagtcaatt tagggttttc aggctaaaat        5820
     tccctgatcc aaataagttt agctttccta cacaagatat atacaaccct gagaagcaaa        5880
     gactagtgtg ggctgtacgt ggaatagaaa tatgtagagg acagcccttg ggtgtaggag        5940
     taacaggtca cccaagcttt aataagttca aagatgcaga aaatctaaac caaaattcag        6000
     atcaaaaaga agatgatagg gttaatgtat gtatggaccc caagcaagtt cagcttttta        6060
     ttgttggctg tgtaccttgt gatggagagc attgggataa ggcacaagct tgtgaaccac        6120
     aaggaccagg ggattgccca cctattgagc tcaaaaacac aaaaatacag gatggtgaaa        6180
     tgtgtgatac agggtttggt aatatgaatt ttgcagcttt gcaagccagc aaatcaggag        6240
     cccctttgga tattgtagac caaatagtaa aataccctga ttttcttaaa atgggtaatg        6300
     acccgtatgg aaattctatg ttcttctatg ctaaaagaga acagatgtat gtcaggcatt        6360
     tatgggctag agcagggaga gtaggagatg atattcctac aggagagtct ggtagcccat        6420
     atttcctacc agccactgga cgaggacccc tgccctcctc agtatatatt ggaagcccca        6480
     gtggatctct ggtatccagt gatcagcaga tttataatag gcccttttgg atacaaaggg        6540
     cacaaggcag taataatggc atgtgctgga acaatgagct ttttgttaca gctgttgata        6600
     gtactagagg cactaacttt agtatatcag tacacactac tgacccagag gttaaaccac        6660
     aagaaactta tacagccact aagtttaagc actacctcag acatgtggaa gaatgggatt        6720
     tgtctttaat tatgcagctt tgcattgtca atctaactcc agaatcaata gcttacctgc        6780
     acaatatgaa tgaaagcatt atagaaaact ggaatttagg ctttattcag ccaccgaatg        6840
     atatagagga ccactacaga tttattacct cattagctac tagatgcccc aaaaagacag        6900
     acactcaggt taaagaagac ccctataaag acctaaagtt ctgggacgtg gacctaacag        6960
     aaaagtttac cacaaacctg aaccagcact ccctggtaag aaaatttttg ttccagatag        7020
     gtagaaaagc taccaaacgc tctgcaccga aaacggtcac atttgaaaat actgaaggta        7080
     aaaaggcgcc aaagcgtagg cggaaaaatg tgtagctgcc aacacctgca gcagtatgag        7140
     caatatgata aataaacttt tctttatgta agatatgaat gttggcaata aaatgcagac        7200
     aaacaaagca ctgttatctt tgggtttttt ttcatctccg gcattgtgtg tttgtgcaag        7260
     c                                                                        7261
//