ID   BPV1R	STANDARD;	ds-DNA;	VRL;	7946 bp.
XX
DE   Bovine papillomavirus type 1 (BPV-1), complete genome. 
XX
AC   <not yet entered in GenBank>
XX
DT   30-SEP-1988
XX
OS   Bovine papillomavirus type 1 DNA from cow, isolate 307. 
OC   Bovine papillomavirus type 1;Viridae; ds-DNA nonenveloped viruses; 
OC   Papovaviridae;Papillomavirus.
XX
RN   [1]
RP   1 - 7946
RA   Chen,E.Y., Howley,P.M., Levinson,A.D. and Seeburg,P.H;
RT   "The primary structure and genetic organization of the bovine 
RT   papillomavirus type 1 genome;"
RL   Nature 299, 529-534 (1982).
XX
RN   [2]
RP   base 3445; revision
RA   Stenlund,A., Zabielski,J., Ahola,H., Moreno-Lopez,J.,and Pettersson,U;
RT   "Messenger RNAs from the transforming region of bovine papilloma virus 
RT   type I;"
RL   J. Mol. Biol. 182, 541-554 (1985).
XX
RN   [3]
RP   7120 - 7399
RA   Baker,C.C., and Howley,P.M;
RT   "Differential promoter utilization by the bovine papillomavirus in 
RT   transformed cells and productively infected wart tissues;"
RL   Embo J. 6, 1027-35 (1987).
XX
RN   [4]
RP   7306 - 7399
RA   Danos,O., Engel,L.W., Chen,E.T., Taniv,M., and Howley,P.M;
RT   "Comparative analysis of the human type 1a and bovine type 1 
RT   papillomavirus genomes;"
RL   J. Virology 46, 557-566 (1983).
XX
RN   [5]
RP   base 7762; revision
RA   Spalholz,B.A., Lambert,P.F., Yee,C.L., and Howley,P.M;
RT   "Bovine papillomavirus transcriptional regulation: localization of the 
RT   E2-responsive elements of the long control region;"
RL   J. Virol. 61, 2128-2137 (1987).
XX
XX   Created by HIV database on 31-MAY-1995 from GenBank: <not.
XX
XX   Full genomic sequences exist for BPV-1, BPV-2 and BPV-4,
XX   EEPV, DPV, and partial genomes for BPV-3, BPV-6 and RPV.
XX   The bovine papillomaviruses can be classified into two
XX   groups, subgroup A (BPV-1, BPV-2 and BPV-5) and subgroup
XX   B (BPV-3, BPV-4 and BPV-6), based on the tissues they
XX   infect (Jackson et al. Mol. Carc. 4: 382-387). The
XX   subgroup A viruses infect both dermal fibroblasts and
XX   squamous epithelial cells (Coggins et al. Vir. 143:
XX   603-611). BPV-1, isolated from a Swedish cow, has been
XX   linked specifically to frond-like fibropapillomas which
XX   occur on the teats, penis, and nose and equine sarcoida,
XX   a benign, naturally occurring fibroblastic tumor in horses
XX   (Coggins et al. Vir. 143: 603-611; Amtmann et
XX   al. J. Virol. 61: 3394-3400). In addition to differences
XX   in host tissue restriction, several other characteristics
XX   distinguish the subgroups of the bovine papillomaviruses.
XX   First, subgroup B viruses have smaller genomes (7.2 kB)
XX   than subgroup A viruses (7.9 kB).  Second, the analogous
XX   position of the subgroup A E6 ORF is occupied by the
XX   subgroup B E8 ORF (Jackson et al. Mol. Carc. 4: 382-387).
XX   This coding region encodes a protein which strongly
XX   resembles the E5 transforming protein of the subgroup A
XX   viruses (Jackson et al. Mol. Carc. 4: 382-387).
XX
XX   The originally published sequence of [1] contained several
XX   sequencing errors which have since been pointed out by 
XX   other authors ([2]-[5]).  These changes, which have been
XX   incorporated into the present entry, are as follows:
XX   insertion of 'g' at bp 3445; substitution of 'c' for 'g'
XX   at bp 7306; deletion of 'g' at bp 7588; insertion of 'c'
XX   at bp 7762 (nucleotide positions given in terms of the
XX   corrected sequence presented herein).
XX
XX
FT  KEY              Location/Qualifiers
FT   TATA_signal     58..63
FT                   /note="putative"
FT   CDS             91..504
FT                   /note="E6 ORF from bp 49 to 504."
FT                   /product="transforming protein"
FT                   /gene="E6"
FT                   /note="putative"
FT                   /codon_start=1
FT                   /translation="MDLKPFARTNPFSGLDCLWCREPLTEVDAFRCMVKDFHVVIREG
FT                   CRYGACTICLENCLATERRLWQGVPVTGEEAELLHGKTLDRLCIRCCYCGGKLTKNEK
FT                   HRHVLFNEPFCKTRANIIRGRCYDCCRHGSRSKYP"
FT   misc_feature    302..308
FT                   /standard_name="Splice donor site"
FT                   /note="putative"
FT   CDS             479..862
FT                   /note="E7 ORF from bp 449 to 862"
FT                   /product="transforming protein"
FT                   /gene="E7"
FT                   /note="putative"
FT                   /codon_start=1
FT                   /translation="MVQGPNTHRNLDDSPAGPLLILSPCAGTPTRSPAAPDAPDFRLP
FT                   CHFGRPTRKRGPTTPPLSSPGKLCATGPRRVYSVTVCCGNCGKELTFAVKTSSTSLLG
FT                   FEHLLNSDLDLLCPRCESRERHGKR"
FT   misc_feature    517..531
FT                   /standard_name="Splice acceptor site"
FT                   /note="putative"
FT   CDS             849..2666
FT                   /note="E1 ORF from bp 813 to 2666"
FT                   /product="replication protein"
FT                   /gene="E1"
FT                   /note="putative"
FT                   /codon_start=1
FT                   /translation="MANDKGSNWDSGLGCSYLLTEAECESDKENEEPGAGVELSVESD
FT                   RYDSQDEDFVDNASVFQGNHLEVFQALEKKAGEEQILNLKRKVLGSSQNSSGSEASET
FT                   PVKRRKSGAKRRLFAENEANRVLTPLQVQGEGEGRQELNEEQAISHLHLQLVKSKNAT
FT                   VFKLGLFKSLFLCSFHDITRLFKNDKTTNQQWVLAVFGLAEVFFEASFELLKKQCSFL
FT                   QMQKRSHEGGTCAVYLICFNTAKSRETVRNLMANTLNVREECLMLQPAKIRGLSAALF
FT                   WFKSSLSPATLKHGALPEWIRAQTTLNESLQTEKFDFGTMVQWAYDHKYAEESKIAYE
FT                   YALAAGSDSNARAFLATNSQAKHVKDCATMVRHYLRAETQALSMPAYIKARCKLATGE
FT                   GSWKSILTFFNYQNIELITFINALKLWLKGIPKKNCLAFIGPPNTGKSMLCNSLIHFL
FT                   GGSVLSFANHKSHFWLASLADTRAALVDDATHACWRYFDTYLRNALDGYPVSIDRKHK
FT                   AAVQIKAPPLLVTSNIDVQAEDRYLYLHSRVQTFRFEQPCTDESGEQPFNITDADWKS
FT                   FFVRLWGRLDLIDEEEDSEEDGDSMRTFTCSARNTNAVD"
FT   misc_feature    862..868
FT                   /standard_name="Splice donor site"
FT                   /note="putative"
FT   CDS             1204..1482
FT                   /note="E8 ORF from bp 1099 to 1482."
FT                   /gene="E8"
FT                   /note="putative"
FT                   /codon_start=1
FT                   /translation="MKLTVFLRPSRYRGRGRGGKNLMRSRQLVIYICSLLNLKMLQFL
FT                   SWGSLNLCSFVASMILRGCLRMIRPLISNGCWLCLALQRCFLRRVSNS"
FT   misc_feature    1233..1239
FT                   /standard_name="Splice donor site"
FT                   /note="putative"
FT   misc_feature    2503..2509
FT                   /standard_name="Splice donor site"
FT                   /note="putative"
FT   CDS             2608..3840
FT                   /note="E2 ORF from bp 2581 to 3840"
FT                   /product="regulatory protein"
FT                   /gene="E2"
FT                   /note="putative"
FT                   /codon_start=1
FT                   /translation="METACERLHVAQETQMQLIEKSSDKLQDHILYWTAVRTENTLLY
FT                   AARKKGVTVLGHCRVPHSVVCQERAKQAIEMQLSLQELSKTEFGDEPWSLLDTSWDRY
FT                   MSEPKRCFKKGARVVEVEFDGNASNTNWYTVYSNLYMRTEDGWQLAKAGADGTGLYYC
FT                   TMAGAGRIYYSRFGDEAARFSTTGHYSVRDQDRVYAGVSSTSSDFRDRPDGVWVASEG
FT                   PEGDPAGKEAEPAQPVSSLLGSPACGPIRAGLGWVRDGPRSHPYNFPAGSGGSILRSS
FT                   STPVQGTVPVDLASRQEEEEQSPDSTEEEPVTLPRRTTNDGFHLLKAGGSCFALISGT
FT                   ANQVKCYRFRVKKNHRHRYENCTTTWFTVADNGAERQGQAQILITFGSPSQRQDFLKH
FT                   VPLPPGMNISGFTASLDF"
FT   CDS             3191..3529
FT                   /note="E4 ORF from bp 3173 to 3529"
FT                   /gene="E4"
FT                   /note="putative"
FT                   /codon_start=1
FT                   /translation="MLVSHPPLLILEIAQTESGSHPKDLKETLQEKKPSQPSLSLLCS
FT                   APPPAVPSEQASVGYGTVLARTPTIFLQARGALFSALPPPRCRARYRWTWHQGRKKRS
FT                   SRPTPQRKNQ"
FT   misc_feature    3214..3228
FT                   /standard_name="Splice acceptor site"
FT                   /note="putative"
FT   CDS             <3267..3554
FT                   /note="No methionine present in ORF."
FT                   /gene="E3"
FT                   /note="putative"
FT                   /codon_start=1
FT                   /translation="RRPCRKRSRASPACLFFARLPRLRSHQSRPRLGTGRSSLAPLQF
FT                   SCRLGGLYSPLFLHPGAGHGTGGLGIKAGRRGAVARLHRGRTSDSPKAHHQ"
FT   misc_difference 3445
FT                   /note="inserted G absent from original sequence, makes
FT                   full E2 ORF"
FT                   /citation=[2]
FT   CDS             <3714..4013
FT                   /note="No methionine present in ORF."
FT                   /gene="E5"
FT                   /note="putative"
FT                   /codon_start=1
FT                   /translation="KTRTSTNTDHLWIAKSKARLSETCTTTSWNEHFRLYSQLGLLIT
FT                   AIAFSSSDWCTMPNLWFLLFLGLVAAMQLLLLLFLLLFFLVYWDHFECSCTGLPF"
FT   TATA_signal     4073..4078
FT                   /note="putative"
FT   polyA_signal    4180..4185
FT                   /note="putative"
FT   CDS             4187..5596
FT                   /note="L2 ORF from bp 4172 to 5596"
FT                   /product="minor capsid protein"
FT                   /gene="L2"
FT                   /note="putative"
FT                   /codon_start=1
FT                   /translation="MSARKRVKRASAYDLYRTCKQAGTCPPDVIRKVEGDTIADKILK
FT                   FGGLAIYLGGLGIGTWSTGRVAAGGSPRYTPLRTAGSTSSLASIGSRAVTAGTRPSIG
FT                   AGIPLDTLETLGALRPGVYEDTVLPEAPAIVTPDAVPADSGLDALSIGTDSSTETLIT
FT                   LLEPEGPEDIAVLELQPLDRPTWQVSNAVHQSSAYHAPLQLQSSIAETSGLENIFVGG
FT                   SGLGDTGGENIELTYFGSPRTSTPRSIASKSRGILNWFSKRYYTQVPTEDPEVFSSQT
FT                   FANPLYEAEPAVLKGPSGRVGLSQVYKPDTLTTRSGTEVGPQLHVRYSLSTIHEDVEA
FT                   IPYTVDENTQGLAFVPLHEEQAGFEEIELDDFSETHRLLPQNTSSTPVGSGVRRSLIP
FT                   TQEFSATRPTGVVTYGSPDTYSASPVTDPDSTSPSLVIDDTTTTPIIIIDGHTVDLYS
FT                   SNYTLHPSLLRKRKKRKHA"
FT   TATA_signal     5090..5095
FT                   /note="putative"
FT   CDS             5609..7096
FT                   /note="L1 ORF from bp 5597 to 7096"
FT                   /product="major capsid protein"
FT                   /gene="L1"
FT                   /note="putative"
FT                   /codon_start=1
FT                   /translation="MALWQQGQKLYLPPTPVSKVLCSETYVQRKSIFYHAETERLLTI
FT                   GHPYYPVSIGAKTVPKVSANQYRVFKIQLPDPNQFALPDRTVHNPSKERLVWPVIGVQ
FT                   VSRGQPLGGTVTGHPTFNALLDAENVNRKVTTQTTDDRKQTGLDAKQQQILLLGCTPA
FT                   EGEYWTTARPCVTDRLENGACPPLELKNKHIEDGDMMEIGFGAANFKEINASKSDLPL
FT                   DIQNEICLYPDYLKMAEDAAGNSMFFFARKEQVYVRHIWTRGGSEKEAPTTDFYLKNN
FT                   KGDATLKIPSVHFGSPSGSLVSTDNQIFNRPYWLFRAQGMNNGIAWNNLLFLTVGDNT
FT                   RGTNLTISVASDGTPLTEYDSSKFNVYHRHMEEYKLAFILELCSVEITAQTVSHLQGL
FT                   MPSVLENWEIGVQPPTSSILEDTYRYIESPATKCASNVIPAKEDPYAGFKFWNIDLKE
FT                   KLSLDLDQFPLGRRFLAQQGAGCSTVRKRRISQKTSSKPAKKKKK"
FT   polyA_signal    6434..6439
FT                   /note="putative"
FT   TATA_signal     6860..6865
FT                   /note="putative"
FT   polyA_signal    7092..7097
FT                   /note="putative"
FT   TATA_signal     7109..7114
FT                   /note="putative"
FT   polyA_signal    7156..7161
FT                   /note="putative"
FT   misc_difference 7306
FT                   /note="G of original sequence changed to C"
FT                   /citation=[4]
FT   misc_difference 7588
FT                   /note="G in original sequence deleted"
FT                   /citation=[4]
FT   misc_difference 7762
FT                   /note="inserted C absent from original sequence"
FT                   /citation=[5]
FT   repeat_region   7779..7807
FT                   /rpt_type=Direct
FT                   /rpt_unit=7779..7788, 7798..7807
FT                   /note="putative"
FT   source          1..7946
FT                   /organism="Bovine papillomavirus type 1"
XX
SQ   SEQUENCE  7946 bp;  2270 a;  1714 c;  1887 g;  2075 t;
     gttaacaata atcacaccat caccgttttt tcaagcggga aaaaatagcc agctaactat        60
     aaaaagctgc tgacagaccc cggttttcac atggacctga aaccttttgc aagaaccaat       120
     ccattctcag ggttggattg tctgtggtgc agagagcctc ttacagaagt tgatgctttt       180
     aggtgcatgg tcaaagactt tcatgttgta attcgggaag gctgtagata tggtgcatgt       240
     accatttgtc ttgaaaactg tttagctact gaaagaagac tttggcaagg tgttccagta       300
     acaggtgagg aagctgaatt attgcatggc aaaacacttg ataggctttg cataagatgc       360
     tgctactgtg ggggcaaact aacaaaaaat gaaaaacatc ggcatgtgct ttttaatgag       420
     cctttctgca aaaccagagc taacataatt agaggacgct gctacgactg ctgcagacat       480
     ggttcaaggt ccaaataccc atagaaactt ggatgattca cctgcaggac cgttgctgat       540
     tttaagtcca tgtgcaggca cacctaccag gtctcctgca gcacctgatg cacctgattt       600
     cagacttccg tgccatttcg gccgtcctac taggaagcga ggtcccacta cgcctccgct       660
     ttcctctccc ggaaaactgt gtgcaacagg gccacgtcga gtgtattctg tgactgtctg       720
     ctgtggaaac tgcggaaaag agctgacttt tgctgtgaag accagctcga cgtccctgct       780
     tggatttgaa caccttttaa actcagattt agacctcttg tgtccacgtt gtgaatctcg       840
     cgagcgtcat ggcaaacgat aaaggtagca attgggattc gggcttggga tgctcatatc       900
     tgctgactga ggcagaatgt gaaagtgaca aagagaatga ggaacccggg gcaggtgtag       960
     aactgtctgt ggaatctgat cggtatgata gccaggatga ggattttgtt gacaatgcat      1020
     cagtctttca gggaaatcac ctggaggtct tccaggcatt agagaaaaag gcgggtgagg      1080
     agcagatttt aaatttgaaa agaaaagtat tggggagttc gcaaaacagc agcggttccg      1140
     aagcatctga aactccagtt aaaagacgga aatcaggagc aaagcgaaga ttatttgctg      1200
     aaaatgaagc taaccgtgtt cttacgcccc tccaggtaca gggggagggg gaggggaggc      1260
     aagaacttaa tgaggagcag gcaattagtc atctacatct gcagcttgtt aaatctaaaa      1320
     atgctacagt ttttaagctg gggctcttta aatctttgtt cctttgtagc ttccatgata      1380
     ttacgaggtt gtttaagaat gataagacca ctaatcagca atgggtgctg gctgtgtttg      1440
     gccttgcaga ggtgtttttt gaggcgagtt tcgaactcct aaagaagcag tgtagttttc      1500
     tgcagatgca aaaaagatct catgaaggag gaacttgtgc agtttactta atctgcttta      1560
     acacagctaa aagcagagaa acagtccgga atctgatggc aaacacgcta aatgtaagag      1620
     aagagtgttt gatgctgcag ccagctaaaa ttcgaggact cagcgcagct ctattctggt      1680
     ttaaaagtag tttgtcaccc gctacactta aacatggtgc tttacctgag tggatacggg      1740
     cgcaaactac tctgaacgag agcttgcaga ccgagaaatt cgacttcgga actatggtgc      1800
     aatgggccta tgatcacaaa tatgctgagg agtctaaaat agcctatgaa tatgctttgg      1860
     ctgcaggatc tgatagcaat gcacgggctt ttttagcaac taacagccaa gctaagcatg      1920
     tgaaggactg tgcaactatg gtaagacact atctaagagc tgaaacacaa gcattaagca      1980
     tgcctgcata tattaaagct aggtgcaagc tggcaactgg ggaaggaagc tggaagtcta      2040
     tcctaacttt ttttaactat cagaatattg aattaattac ctttattaat gctttaaagc      2100
     tctggctaaa aggaattcca aaaaaaaact gtttagcatt tattggccct ccaaacacag      2160
     gcaagtctat gctctgcaac tcattaattc attttttggg tggtagtgtt ttatcttttg      2220
     ccaaccataa aagtcacttt tggcttgctt ccctagcaga tactagagct gctttagtag      2280
     atgatgctac tcatgcttgc tggaggtact ttgacacata cctcagaaat gcattggatg      2340
     gctaccctgt cagtattgat agaaaacaca aagcagcggt tcaaattaaa gctccacccc      2400
     tcctggtaac cagtaatatt gatgtgcagg cagaggacag atatttgtac ttgcatagtc      2460
     gggtgcaaac ctttcgcttt gagcagccat gcacagatga atcgggtgag caacctttta      2520
     atattactga tgcagattgg aaatcttttt ttgtaaggtt atgggggcgt ttagacctga      2580
     ttgacgagga ggaggatagt gaagaggatg gagacagcat gcgaacgttt acatgtagcg      2640
     caagaaacac aaatgcagtt gattgagaaa agtagtgata agttgcaaga tcatatactg      2700
     tactggactg ctgttagaac tgagaacaca ctgctttatg ctgcaaggaa aaaaggggtg      2760
     actgtcctag gacactgcag agtaccacac tctgtagttt gtcaagagag agccaagcag      2820
     gccattgaaa tgcagttgtc tttgcaggag ttaagcaaaa ctgagtttgg ggatgaacca      2880
     tggtctttgc ttgacacaag ctgggaccga tatatgtcag aacctaaacg gtgctttaag      2940
     aaaggcgcca gggtggtaga ggtggagttt gatggaaatg caagcaatac aaactggtac      3000
     actgtctaca gcaatttgta catgcgcaca gaggacggct ggcagcttgc gaaggctggg      3060
     gctgacggaa ctgggctcta ctactgcacc atggccggtg ctggacgcat ttactattct      3120
     cgctttggtg acgaggcagc cagatttagt acaacagggc attactctgt aagagatcag      3180
     gacagagtgt atgctggtgt ctcatccacc tcttctgatt ttagagatcg cccagacgga      3240
     gtctgggtcg catccgaagg acctgaagga gaccctgcag gaaaagaagc cgagccagcc      3300
     cagcctgtct cttctttgct cggctccccc gcctgcggtc ccatcagagc aggcctcggt      3360
     tgggtacggg acggtcctcg ctcgcacccc tacaattttc ctgcaggctc ggggggctct      3420
     attctccgct cttcctccac cccggtgcag ggcacggtac cggtggactt ggcatcaagg      3480
     caggaagaag aggagcagtc gcccgactcc acagaggaag aaccagtgac tctcccaagg      3540
     cgcaccacca atgatggatt ccacctgtta aaggcaggag ggtcatgctt tgctctaatt      3600
     tcaggaactg ctaaccaggt aaagtgctat cgctttcggg tgaaaaagaa ccatagacat      3660
     cgctacgaga actgcaccac cacctggttc acagttgctg acaacggtgc tgaaagacaa      3720
     ggacaagcac aaatactgat cacctttgga tcgccaagtc aaaggcaaga ctttctgaaa      3780
     catgtaccac tacctcctgg aatgaacatt tccggcttta cagccagctt ggacttctga      3840
     tcactgccat tgccttttct tcatctgact ggtgtactat gccaaatcta tggtttctat      3900
     tgttcttggg actagttgct gcaatgcaac tgctgctatt actgttctta ctcttgtttt      3960
     ttcttgtata ctgggatcat tttgagtgct cctgtacagg tctgcccttt taatgccttt      4020
     acatcactgg ctattggctg tgtttttact gttgtgtgga tttgatttgt tttatatact      4080
     gtatgaagtt ttttcatttg tgcttgtatt gctgtttgta agttttttac tagagtttgt      4140
     attccccctg ctcagatttt atatggttta agctgcagca ataaaaatga gtgcacgaaa      4200
     aagagtaaaa cgtgccagtg cctatgacct gtacaggaca tgcaagcaag cgggcacatg      4260
     tccaccagat gtgataccaa aggtagaagg agatactata gcagataaaa ttttgaaatt      4320
     tgggggtctt gcaatctact taggagggct aggaatagga acatggtcta ctggaagggt      4380
     tgctgcaggt ggatcaccaa ggtacacacc actccgaaca gcagggtcca catcatcgct      4440
     tgcatcaata ggatccagag ctgtaacagc agggacccgc cccagtatag gtgcgggcat      4500
     tcctttagac acccttgaaa ctcttggggc cttgcgtcca ggggtgtatg aggacactgt      4560
     gctaccagag gcccctgcaa tagtcactcc tgatgctgtt cctgcagatt cagggcttga      4620
     tgccctgtcc ataggtacag actcgtccac ggagaccctc attactctgc tagagcctga      4680
     gggtcccgag gacatagcgg ttcttgagct gcaacccctg gaccgtccaa cttggcaagt      4740
     aagcaatgct gttcatcagt cctctgcata ccacgcccct ctgcagctgc aatcgtccat      4800
     tgcagaaaca tctggtttag aaaatatttt tgtaggaggc tcgggtttag gggatacagg      4860
     aggagaaaac attgaactga catacttcgg gtccccacga acaagcacgc cccgcagtat      4920
     tgcctctaaa tcacgtggca ttttaaactg gttcagtaaa cggtactaca cacaggtgcc      4980
     cacggaagat cctgaagtgt tttcatccca aacatttgca aacccactgt atgaagcaga      5040
     accagctgtg cttaagggac ctagtggacg tgttggactc agtcaggttt ataaacctga      5100
     tacacttaca acacgtagcg ggacagaggt gggaccacag ctacatgtca ggtactcatt      5160
     gagtactata catgaagatg tagaagcaat cccctacaca gttgatgaaa atacacaggg      5220
     acttgcattc gtacccttgc atgaagagca agcaggtttt gaggagatag aattagatga      5280
     ttttagtgag acacatagac tgctacctca gaacacctct tctacacctg ttggtagtgg      5340
     tgtacgaaga agcctcattc caactcagga atttagtgca acacggccta caggtgttgt      5400
     aacctatggc tcacctgaca cttactctgc tagcccagtt actgaccctg attctacctc      5460
     tcctagtcta gttatcgatg acactactac tacaccaatc attataattg atgggcacac      5520
     agttgatttg tacagcagta actacacctt gcatccctcc ttgttgagga aacgaaaaaa      5580
     acggaaacat gcctaatttt ttttgcagat ggcgttgtgg caacaaggcc agaagctgta      5640
     tctccctcca acccctgtaa gcaaggtgct ttgcagtgaa acctatgtgc aaagaaaaag      5700
     cattttttat catgcagaaa cggagcgcct gctaactata ggacatccat attacccagt      5760
     gtctatcggg gccaaaactg ttcctaaggt ctctgcaaat cagtataggg tatttaaaat      5820
     acaactacct gatcccaatc aatttgcact acctgacagg actgttcaca acccaagtaa      5880
     agagcggctg gtgtgggcag tcataggtgt gcaggtgtcc agagggcagc ctcttggagg      5940
     tactgtaact gggcacccca cttttaatgc tttgcttgat gcagaaaatg tgaatagaaa      6000
     agtcaccacc caaacaacag atgacaggaa acaaacaggc ctagatgcta agcaacaaca      6060
     gattctgttg ctaggctgta cccctgctga aggggaatat tggacaacag cccgtccatg      6120
     tgttactgat cgtctagaaa atggcgcctg ccctcctctt gaattaaaaa acaagcacat      6180
     agaagatggg gatatgatgg aaattgggtt tggtgcagcc aacttcaaag aaattaatgc      6240
     aagtaaatca gatctacctc ttgacattca aaatgagatc tgcttgtacc cagactacct      6300
     caaaatggct gaggacgctg ctggtaatag catgttcttt tttgcaagga aagaacaggt      6360
     gtatgttaga cacatctgga ccagaggggg ctcggagaaa gaagccccta ccacagattt      6420
     ttatttaaag aataataaag gggatgccac ccttaaaata cccagtgtgc attttggtag      6480
     tcccagtggc tcactagtct caactgataa tcaaattttt aatcggccct actggctatt      6540
     ccgtgcccag ggcatgaaca atggaattgc atggaataat ttattgtttt taacagtggg      6600
     ggacaataca cgtggtacta atcttaccat aagtgtagcc tcagatggaa ccccactaac      6660
     agagtatgat agctcaaaat tcaatgtata ccatagacat atggaagaat ataagctagc      6720
     ctttatatta gagctatgct ctgtggaaat cacagctcaa actgtgtcac atctgcaagg      6780
     acttatgccc tctgtgcttg aaaattggga aataggtgtg cagcctccta cctcatcgat      6840
     attagaggac acctatcgct atatagagtc tcctgcaact aaatgtgcaa gcaatgtaat      6900
     tcctgcaaaa gaagaccctt atgcagggtt taagttttgg aacatagatc ttaaagaaaa      6960
     gctttctttg gacttagatc aatttccctt gggaagaaga tttttagcac agcaaggggc      7020
     aggatgttca actgtgagaa aacgaagaat tagccaaaaa acttccagta agcctgcaaa      7080
     aaaaaaaaaa aaataaaagc taagtttcta taaatgttct gtaaatgtaa aacagaaggt      7140
     aagtcaactg cacctaataa aaatcactta atagcaatgt gctgtgtcag ttgtttattg      7200
     gaaccacacc cggtacacat cctgtccagc atttgcagtg cgtgcattga attattgtgc      7260
     tggctagact tcatggcgcc tggcaccgaa tcctgccttc tcagccaaaa tgaataattg      7320
     ctttgttggc aagaaactaa gcatcaatgg gacgcgtgca aagcaccggc ggcggtagat      7380
     gcggggtaag tactgaattt taattcgacc tatcccggta aagcgaaagc gacacgcttt      7440
     tttttcacac atagcgggac cgaacacgtt ataagtatcg attaggtcta tttttgtctc      7500
     tctgtcggaa ccagaactgg taaaagtttc cattgcgtct gggcttgtct atcattgcgt      7560
     ctctatggtt tttggaggat tagacgggcc accagtaatg gtgcatagcg gatgtctgta      7620
     ccgccatcgg tgcaccgata taggtttggg gctccccaag ggactgctgg gatgacagct      7680
     tcatattata ttgaatgggc gcataatcag cttaattggt gaggacaagc tacaagttgt      7740
     aacctgatct ccacaaagta ccgttgccgg tcggggtcaa accgtcttcg gtgctcgaaa      7800
     ccgccttaaa ctacagacag gtcccagcca agtaggcgga tcaaaacctc aaaaaggcgg      7860
     gagccaatca aaatgcagca ttatatttta agctcaccga aaccggtaag taaagactat      7920
     gtattttttc ccagtgaata attgtt                                           7946